CSCL for intellectually disabled pupils: Stimulating interaction by using a floor control mechanism

Computer-supported collaborative learning has an unexploited potential of becoming an effective learning method for pupils with intellectual disabilities. This paper aims at showing how some specific requirements of this target group may be met by structuring a learning situation with the help of floor control, which restricts the opportunities of a learning dyad to act simultaneously within the learning environment. It was expected that floor control could improve communication between pupils with intellectual disabilities by explicitly structuring and restricting activities in the learning environment and making it necessary for the pupils to communicate. To examine if floor control really supports the collaboration process in the hypothesized way, two different versions of a CSCL environment were implemented and compared. The results revealed improved task-related communication and a higher quality of interaction outcomes.     

Equivalence Problems for Circuits over Sets of Natural Numbers

We investigate the complexity of equivalence problems for {∪,∩,⁻,+,×}-circuits computing sets of natural numbers. These problems were first introduced by Stockmeyer and Meyer (1973). We continue this line of research and give a systematic characterization of the complexity of equivalence problems over sets of natural numbers. Our work shows that equivalence problems capture a wide range of complexity classes like NL, C ₌ L, P,Π₂^P, PSPACE, NEXP, and beyond. McKenzie and Wagner (2003) studied related membership problems for circuits over sets of natural numbers. Our results also have consequences for these membership problems: We provide an improved upper bound for the case of {∪,∩,⁻,+,×}-circuits.     

Influence of store dimensions and auxiliary volume configuration on the performance of medium-sized solar combisystems

To increase the fractional energy savings achieved with solar thermal combisystems the store volume may be increased. Installation of large stores in single-family houses is, however, often limited by space constraints. In this article the influence of the store dimensions, as well as internal and external auxiliary volume configurations, are investigated for large solar water stores by annual dynamic TRNSYS simulations. The results show that store sizes up to 4 m³ may be used in solar heating systems with 30 m² collector area. It is further shown that well-insulated stores are rather insensitive to the geometry. Stores deviating from the conventional dimensions still yield high fractional energy savings. Furthermore, the simulations show that the performance of an internal auxiliary volume configuration in most cases exceeds that of a solution with an external auxiliary unit. The practical limitations of very thin auxiliary volumes must, however, be further investigated.     

Managing one’s identities in organisational and social settings

Interacting in the Internet, users should be empowered to use only those subsets of their personal attributes, called partial identities, which are appropriate for the actual situation and context. Refraining from acting under few and easily linkable partial identities is a prerequisite for trustworthy privacy. Traditionally user-controlled identity management systems primarily support individuals interacting with organisations, but mainly ignore special needs which arise if individuals interact with each other. To support online communities those systems have to change. From TU Dresden: Prof. Dr. Andreas Pfitzmann, head of the privacy and security group, and the research assistants Dipl.-Inform. Katrin Borcea-Pfitzmann, Dipl. Medien-inf. Katja Liesebach and Dipl.-Inform. Sandra Steinbrecher. From ULD, Kiel: Dipl.-Inform. Marit Hansen, head of PET division. Research Focus: Privacy in Identity Management and Application Design This work was funded in part by the PRIME project which receives research funding from the European Union’s Sixth Framework Programme and the Swiss Federal Office for Education and Science.     

Reed canary grass yield and fuel quality in Estonian farmers’ fields

Reed canary grass (Phalaris arundinacea) is one of the possible raw materials for bioenergy production in northern Europe. Its cultivation is favoured because its high productivity and local origin. However, problems with the biomass quality for combustion have been reported. Usually delayed harvest in spring is suggested to improve the quality and decrease the moisture content of biomass. On the other hand, the feasibility of spring harvest depends on local climatic conditions and may cause yield losses. In current paper we studied reed canary grass fields in Estonia locating on different soil types and cultivated with various varieties. The influence of several fertilisation schemes on biomass yield was analysed. Our results indicated that production was higher on mineral soils than on the organic soil of abandoned peat extraction sites. Even different types of fertilisation did not increase the production on organic soils to the level comparable to those on mineral soils. Among studied varieties ‘Venture’ had the highest production. The highest yield per area was obtained late in the autumn (12.7 t d.w. per ha and 7.2 t d.w. per ha on mineral and organic soils, respectively). By spring the amount of biomass had decreased in all studied sites. Due to wet soil some of the fields remained unharvested, the others had high yield losses during practical harvesting. The chemical analyses did not reveal significant differences in the composition of biomass between late autumn and spring. Therefore we conclude that late autumn harvest should be preferred in local climatic conditions.     

Highly adaptable and sensitive protease assay based on fluorescence resonance energy transfer

Proteases are widely used in analytical sciences and play a central role in several widespread diseases. Thus, there is an immense need for highly adaptable and sensitive assays for the detection and monitoring of various proteolytic enzymes. We established a simple protease fluorescence resonance energy transfer (pro-FRET) assay for the determination of protease activities, which could in principle be adapted for the detection of all proteases. As proof of principle, we demonstrated the potential of our method using trypsin and enteropeptidase in complex biological mixtures. Briefly, the assay is based on the cleavage of a FRET peptide substrate, which results in a dramatic increase of the donor fluorescence. The assay was highly sensitive and fast for both proteases. The detection limits for trypsin and enteropeptidase in Escherichia coli lysate were 100 and 10 amol, respectively. The improved sensitivity for enteropeptidase was due to the application of an enzyme cascade, which leads to signal amplification. The pro-FRET assay is highly specific as even high concentrations of other proteases did not result in significant background signals. In conclusion, this sensitive and simple assay can be performed in complex biological mixtures and can be easily adapted to act as a versatile tool for the sensitive detection of proteases.     

Wasserbindungskapazit?t und Makrostruktur von Apfelgewebepartikeln

Zusammenfassung Haufwerke aus trockenen Apfelgewebepartikeln mit mittleren Partikelvolumina zwischen 0,3 und 5 mm³ können bis zu 80 g/g Wasser aufnehmen. Der überwiegende Teil dieses Wassers ist in makrocapillaren Haufwerks- und Partikelhohlräumen eingelagert und nur durch sehr geringe Kräfte gebunden. Bereits bei Einwirkung eines Gasdrucks von 2 kPa werden die Partikelhaufwerke stark entwässert. Die Wasserbeladung sinkt auf 20-15 g/g. Die Rehydratation einzelner getrockneter Apfelgewebepartikel ist vom Ausmaß der bei der Zerkleinerung eingetretenen Gewebezerstörung abhängig und kann durch eine der Trocknung vorgelagerte Entwässerung mit Ethanol verbessert werden. Vorentwässerte Partikel mit einem hohen Ethanolgehalt schrumpfen bei der Trocknung im geringeren Ausmaß und besitzen eine hohe Porosität. Solche Partikel binden im rehydratisierten Zustand bis zu 30 g/g Wasser. Nicht mit Ethanol behandelte Partikel binden unter 11 g/g Wasser.

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Water binding capacity and macrostructure of apple tissue particles

Samples (bulk materials) of dry apple tissue particles in a range of particle volume from 0.3 to 5 mm³ can absorb up to 80 g/g water. Most of this water is included in macrocapillary bulk and particle spaces and is bound by very small forces. An external gas pressure of 2 kPa decreases the water content to 20-15 g/g. The rehydration properties of single apple tissue particles depend on the degree of tissue disintegration and can be improved by a dehydration treatment with ethanol before drying. Such pre-dehydrated particles with a high ethanol concentration in the liquid phase show little shrinkage during the drying process and have a high porosity. They retain up to 30 g/g water after rehydration. The water uptake of non-ethanol-treated particles is less than 11 g/g.

     

Three generations of cyclosporine a formulations: an in vitro comparison

When the microemulsion formulation of the critical dose drug cyclosporine A (CsA) (Sandimmun Optoral) was introduced in the mid-1990s, it became clear that this new formulation improves the oral bioavailability of CsA and has a positive influence on its pharmacokinetic variability. Previous studies with the original CsA formulation (Sandimmun) showed that the size of the emulsion droplets and concomitant food intake has an effect on the absorption of CsA from the small intestine when orally administered. It was suggested that these effects might have an influence on the drugs' pharmacokinetic parameters.In this study, we focused on the two above-mentioned aspects and compared the first and second generations of CsA products (Sandimmun, Sandimmun Optoral) to generic CsA formulations by analyzing the contents of cyclosporine A gel capsules with respect to their emulsion droplet and micelle sizes using photon correlation spectroscopy (PCS). We tried to discern any differences in droplet size between different generations of CsA formulations, primarily the second and third generation, through simple physical tests. Because a high fat content food may influence the absorption of CsA, we also determined the distribution of CsA between hydrophilic and lipophilic phases using high-performance liquid chromatography analysis.It became clear that when compared under simple physical conditions, established cyclosporine formulations and new generic products show significant differences in droplet size and distribution between an aqueous phase and a high fat content food. Whether these differences are of clinical relevance remains to be investigated.