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排序方式: 共有577条查询结果,搜索用时 15 毫秒
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Autonomous control of vehicles has recently attracted considerable attention. In this sense, vehicle merging has become an important topic in this field of research. However, in conventional studies, the controlled vehicle must calculate the movement of other surrounding vehicles to complete the merge, requiring high computational costs. In this paper, we focus on dragonfly behavior to solve this issue. Indeed, insects can behave adaptively in the complex real world in spite of the limited size of their brains. They reduce the computational requirements of their brain by relying on different properties of their surroundings, basing their intelligent behaviors on simple strategies. The behavior of a dragonfly when chasing a prey is an example of these strategies. In this study, we address the vehicle merging maneuver by applying dragonfly’s strategies to control the movement of the merging vehicle. We propose a simple control method inspired by the aforementioned strategies and, finally, we present simulation results that were conducted to demonstrate the effectiveness of this method. 相似文献
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Shū Kobayashi Kentaro Kakumoto Yuichiro Mori Kei Manabe 《Israel journal of chemistry》2001,41(4):247-250
Asymmetric Michael reactions of ß-ketoesters with enones were effectively catalyzed by complexes of silver salts and BINAP derivatives in water. The reactions have proved to give Michael adducts in high yields with high enantioselectivities. These reactions are the first example of Lewis acid-catalyzed asymmetric Michael reactions in water. 相似文献
25.
Ozlem Yildiz Johannes Schroth Vittoria Lombardi Valentina Pucino Yoana Bobeva Ping Kei Yip Klaus Schmierer Claudio Mauro Timothy Tree Sian Mari Henson Andrea Malaspina 《International journal of molecular sciences》2022,23(6)
Monocytes expressing the inflammation suppressing active CD11b, a beta2 integrin, may regulate neuroinflammation and modify clinical outcomes in amyotrophic lateral sclerosis (ALS). In this single site, retrospective study, peripheral blood mononuclear cells from 38 individuals living with ALS and 20 non-neurological controls (NNC) were investigated using flow cytometry to study active CD11b integrin classical (CM), intermediate (IM) and non-classical (NCM) monocytes during ALS progression. Seventeen ALS participants were sampled at the baseline (V1) and at two additional time points (V2 and V3) for longitudinal analysis. Active CD11b+ CM frequencies increased steeply between the baseline and V3 (ANOVA repeated measurement, p < 0.001), and the V2/V1 ratio negatively correlated with the disease progression rate, similar to higher frequencies of active CD11b+ NCM at the baseline (R = −0.6567; p = 0.0031 and R = 0.3862; p = 0.0168, respectively). CD11b NCM, clinical covariates and neurofilament light-chain plasma concentration at the baseline predicted shorter survival in a multivariable and univariate analysis (CD11b NCM—HR: 1.05, CI: 1.01–1.11, p = 0.013. Log rank: above median: 43 months and below median: 21.22 months; p = 0.0022). Blood samples with the highest frequencies of active CD11b+ IM and NCM contained the lowest concentrations of soluble CD11b. Our preliminary data suggest that the levels of active CD11b+ monocytes and NCM in the blood predict different clinical outcomes in ALS. 相似文献
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Naoki Motomura Yuto Yamazaki Daiki Koga Shogo Harashima Xin Gao Yuta Tezuka Kei Omata Yoshikiyo Ono Ryo Morimoto Fumitoshi Satoh Yasuhiro Nakamura Go Eun Kwon Man Ho Choi Akihiro Ito Hironobu Sasano 《International journal of molecular sciences》2022,23(4)
Cortisol-producing adenoma (CPA) is composed of clear and compact cells. Clear cells are lipid abundant, and compact ones lipid poor but associated with higher production of steroid hormones. PRKACA mutation (PRKACA mt) in CPA patients was reported to be associated with more pronounced clinical manifestation of Cushing’s syndrome. In this study, we examined the association of histological features and genotypes with cholesterol uptake receptors and synthetic enzymes in 40 CPA cases, and with the quantitative results obtained by gas chromatography-mass spectrometry (GC-MS) analysis in 33 cases to explore their biological and clinical significance. Both cholesterol uptake receptors and synthetic enzymes were more abundant in compact cells. GC-MS analysis demonstrated that the percentage of compact cells was inversely correlated with the concentrations of cholesterol and cholesterol esters, and positively with the activity of cholesterol biosynthesis from cholesterol esters. In addition, hormone-sensitive lipase (HSL), which catalyzes cholesterol biosynthesis from cholesterol esters, tended to be more abundant in compact cells of PRKACA mt CPAs. These results demonstrated that both cholesterol uptake and biosynthesis were more pronounced in compact cells in CPA. In addition, more pronounced HSL expression in compact cells of PRKACA mt CPA could contribute to their more pronounced clinical manifestation. 相似文献
27.
Hideki Shige Toshitsugu Ishikawa Michio Suzukawa Masato Nishiwaki Takeshi Yamashita Kei Nakajima Toshimitsu Ito Kenji Higashi Makoto Ayaori Atsushi Yonemura Paul Nestel Haruo Nakamura 《Lipids》1998,33(12):1169-1175
The effects of vitamin E on cholesteryl ester (CE) metabolism in 1774 cells were examined. Pretreatment of 1774 cells with
vitamin E at concentrations above 50 μM significantly decreased acetylated low density lipoprotein (LDL)-induced incorporation
of [14C]oleate into CF in cells in a dose-dependent manner. This was partly due to vitamin E Also significantly inhibiting the uptake
of [3H]CE-labeled acetylated LDL by 1774 cells. A trend existed toward suppression of acyl-CoA:cholesterol acyltransferase (ACAT)
activity in the cell lysate at high vitamin E concentration, but there was no effect on hydrolysis of CE. These data indicate
that vitamin E reduces the uptake of modified LDL and suppresses ACAT activity, resulting in less cholesterol esterification
in macrophages; a novel mechanism underlying the antiatherogenic properties of vitamin E. 相似文献
28.
Shin‐ich Sakasegawa Shu Taira Kei Yamamoto Daisuke Sugimori 《European Journal of Lipid Science and Technology》2020,122(2)
Many phospholipase Ds (PLDs) are known to catalyze transphosphatidylation as well as hydrolysis of phospholipids. Transphosphatidylation of lysoplasmalogen (LyPls)‐specific phospholipase D (LyPls‐PLD), which catalyzes hydrolysis of ether lysophospholipids such as LyPls and 1‐hexadecyl‐2‐hydroxy‐sn‐glycero‐3‐phosphocholine (Lyso‐PAF), still remains unclear. This study aims to reveal the transphosphatidylation activity of LyPls‐PLD, that is, the production of cyclic ether lysophospholipid. The enzymatic reaction is conducted in a buffer system, and the reaction products of a novel LyPls‐PLD from Thermocrispum sp. are investigated using mass spectrometry (MS). MS analyses demonstrate the reaction products to consist of 100% 1‐hexadecyl‐2‐hydroxy‐sn‐glycero‐2,3‐cyclic‐phosphate (cLyPA) and choline from Lyso‐PAF; however, 1‐alkenyl‐2‐hydroxy‐sn‐glycero‐2,3‐cyclic‐phosphate from 1‐O‐1′‐(Z)‐octadecenyl‐2‐hydroxy‐sn‐glycero‐3‐phosphocholine and 1‐O‐1′‐(Z)‐octadecenyl‐2‐hydroxy‐sn‐glycero‐3‐phosphoethanolamine is not produced. These results are expected to help in elucidating the catalytic mechanism of LyPls‐PLD, that is, the rate‐limiting step, and indicate LyPls‐PLD to be useful for the one‐pot synthesis of cLyPA. Practical Applications: A novel phospholipase D, LyPls‐PLD, can exclusively synthesize cLyPA from Lyso‐PAF using a one‐step enzymatic reaction without an organic solvent. cLyPA could be expected to show bioactivities similar to those of cyclic phosphatidic acid, which promotes normal cell differentiation, hyaluronic acid synthesis, antiproliferative activity in fibroblasts, and inhibitory activity toward cancer cell invasion and metastasis. 相似文献
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Iron–Nitrogen‐Doped Vertically Aligned Carbon Nanotube Electrocatalyst for the Oxygen Reduction Reaction
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Satoshi Yasuda Atom Furuya Yosuke Uchibori Jeheon Kim Kei Murakoshi 《Advanced functional materials》2016,26(5):738-744
A highly active iron–nitrogen‐doped carbon nanotube catalyst for the oxygen reduction reaction (ORR) is produced by employing vertically aligned carbon nanotubes (VA‐CNT) with a high specific surface area and iron(II) phthalocyanine (FePc) molecules. Pyrolyzing the composite easily transforms the adsorbed FePc molecules into a large number of iron coordinated nitrogen functionalized nanographene (Fe–N–C) structures, which serve as ORR active sites on the individual VA‐CNT surfaces. The catalyst exhibits a high ORR activity, with onset and half‐wave potentials of 0.97 and 0.79 V, respectively, versus reversible hydrogen electrode, a high selectivity of above 3.92 electron transfer number, and a high electrochemical durability, with a 17 mV negative shift of E 1/2 after 10 000 cycles in an oxygen‐saturated 0.5 m H2SO4 solution. The catalyst demonstrates one of the highest ORR performances in previously reported any‐nanotube‐based catalysts in acid media. The excellent ORR performance can be attributed to the formation of a greater number of catalytically active Fe–N–C centers and their dense immobilization on individual tubes, in addition to more efficient mass transport due to the mesoporous nature of the VA‐CNTs. 相似文献