Two hundred and fifteen children aged 4 months 6 years with acute otitis media (AOM) were randomized to be treated either by a single i.m. injection of ceftriaxone, 50 mg/kg, with a second dose in the event of unsatisfactory response after 48 h or a history of recurrent AOM (109 patients) or amoxicillin clavulanate 12.5 mg tid (106 patients). The failure rate was similar in children treated by ceftriaxone and amoxicillin clavulanate, 4.6% and 4.7%, respectively (standard error for intergroup difference -2.87%, 95% confidence interval -5.62% to 5.87%). No significant differences between the groups were found in the dynamics of the resolution of the acute symptomatology, otoscopy findings, relapse rate at 30 days or tympanographic evidence of middle ear effusion at the scheduled visits on days 30, 60 and 90. Recurrence of AOM between days 31 and 90 was observed significantly in more children treated with amoxicillin clavulanate than with ceftriaxone--25 out of 84 (29.4%) versus 11 out of 81 (13.6%) (P = 0.012). Conclusion: Ceftriaxone injection(s) is as efficient at least as 10-day oral amoxicillin clavulanate for treatment of acute otitis media in children. Although not recommended as routine, ceftriaxone can be considered in the management of acute otitis media under special circumstances, particularly in cases when the ability to tolerate or absorb oral drugs is compromised, in children refusing or unable to take oral therapy or when the compliance is questionable. 相似文献
Remote procedure call (RPC) mechanisms over the US Department of Defense transmission control protocol. (TCP) can produce behavior analogous to the silly window syndrome because of a mismatched interface between the socket and the TCP modules. The detection and diagnosis of the problem are addressed. Some pointers to a design approach that could avoid the problems of mismatched communication layers are provided 相似文献
We evaluated the effects of various hematopoietic growth factors (HGFs) on the prevention of apoptosis in blasts from 19 patients with acute myeloblastic leukemia (AML) by assessing DNA ladder formation. After incubation without HGF, apoptosis was noted in all but two patients. HGFs prevented, did not affect, or enhanced apoptosis in 39 (60%), 14 (22%), or 12 (18%) of 65 suspension cultures, respectively. HGFs that prevented apoptosis also stimulated and/or synergized blast colony formation in 35 of 39 corresponding methylcellulose cultures. HGFs that alone stimulated colony formation also prevented apoptosis in all but two of 28 corresponding suspension cultures. In contrast, HGFs that did not prevent apoptosis also failed to stimulate growth in 17 of 26 corresponding methylcellulose cultures. HGFs that enhanced apoptosis alone never stimulated colony formation. After incubation, we noted enhanced c-fos and cjun genes as well as induction of p21 protein. An appropriate dose of HGF elevated c-fos, reduced c-jun and p21, induced G1/S transition, and inhibited apoptosis. In two patients, apoptosis was not induced after incubation. Cells not treated with HGF expressed no c-fos, c-jun, or c-myc, and remained in G0/G1. Taken together, our results support the conclusion that not only c-fos, cjun, and c-myc, but also p53 and p21 are required for blast apoptosis. HGF differentially prevents apoptosis and induces mitosis, and both events seem to be integral to the self-renewal of AML clonogenic cells. 相似文献
The resonance frequency, internal friction, and emf of the double conversion are measured in samples of ZhGr steels of the variable density and carbon content by means of the resonance electromagnetic-acoustic conversion method. For the contactless excitation, the close correlation between the density (porosity) and the resonance frequency of the ultrasonic vibrations is obtained. It is shown that the magnetic state of the samples affects the internal friction. The dynamics of the field dependences of the emf is investigated with allowance for the internal friction in variation of the carbon content. This makes it possible to determine the optimum interval of the field for estimating this parameter. 相似文献
The thermal behaviour of a packed bed storage system charged with hot air is modelled using two partial differential equations representing the energy conservation in the air and solid phases constituting the bed. These two equations are coupled through the heat exchange process between the two phases. A fully implicit numerical scheme based on forward, upwind and central differencing for the time, first and second space derivatives, respectively, is used to solve the modelling equations. Marching technique is used for the air equation and a tri-diagonal matrix solver is employed to solve the solid equation. The solution yields the thermal structure of the bed, namely the air and solid temperature distribution inside the bed at any particular time, and the variation of total energy stored in the bed with time. The effect of bed length, solid diameter and void fraction on the thermal characteristics of the packed bed is studied. Further, the performance of the bed under variable inlet air temperature and mass flow rate is investigated. 相似文献
This paper presents a project undertaken for the European Space Agency (ESA). The project is developing a knowledge based system for planning and scheduling of activities for spacecraft assembly, integration and verification (AIV). The system extends to the monitoring of plan execution and the plan repair phases.
The objectives of the contract are to develop an operational kernel of a planning, scheduling and plan repair tool, called OPTIMUM-AIV, and to provide facilities which will allow individual projects to customize the kernel to suit its specific needs. The kernel shall consist of a set of software functionalities for assistance in the initial specification of the AIV plan, in the verification and generation of valid plans and schedules for the AIV activities, and in interactive monitoring and execution problem recovery for the detailed AIV plans. Embedded in OPTIMUM-AIV are external interfaces which allow integration with alternative scheduling systems and project databases.
The current status of the OPTIMUM-AIV project, as of May 1991, is that the architectural design of the system has been agreed on by ESTEC/ESA and detailed design and implementation is now underway, expecting a final delivery in October of 1991. 相似文献
Conclusions 1. Adequate experience and knowledge has been accumulated in the Khimtekstil'mash NPO to make it possible to develop equipment for the manufacture of CF which conform to the contemporary world level. In recent years work on developing new equipment and improving existing equipment for the manufacture of CF have not received new development because of the lack of financing. One must also note the decrease in tempo of work on technological assurance, which is reflected in the technical level of equipment being developed.2. In connection with the high cost of work on developing new technologies and equipment for the manufacture of CF, these problems require solution at the state and in first-state level, since CF are materials not only for the present but also mainly for the future.Deceased.Khimtekstil'mash NPO (Chernigov). Translated from Khimicheskie Volokna, No. 5, pp. 33–35, September–October, 1993. 相似文献