Approximation of structural optimization problems by means of designed numerical experiments

In this paper we describe an approach in which the Experimental Design Theory (EDT) (see Montgomery and Wiley 1984; Kiefer and Wolfowitz 1959; Fedorov 1972) is used as a tool in building approximate analysis models to be applied in structural optimization problems. This theory has been developed for the planning and analysis of comprehensive physical experiments in order to reduce the number of required experiments while preserving the amount of information that can be extracted from them. This situation is very similar to that of structural optimization, where the number of expensive finite element (FEM) analyses has to be minimized (Schoofs 1987). FEM computations can be regarded as numerical experiments, where the design variables are treated as input quantities. All computable properties of the structure, such as weight, displacements, stresses, etc. can be regarded as response quantities of the numerical experiment. The approximating models will be derived for these responses by using regression techniques, and they can be substituted in the optimization problem for the definition of the objective and the constraint functions. The application of the proposed method is illustrated with two case studies.Presented at NATO ASI Optimization of Large Structural Systems, Berchtesgaden, Sept. 23 – Oct. 4, 1991     

Effects of habitat restoration on the macroinvertebrate fauna in a foreland along the river waal,the main distributary in the Rhine delta

River engineering in the Rhine delta and water pollution have been major threats for the ecological functioning of the river in The Netherlands. To mitigate effects of river engineering, secondary channel construction in the forelands along the existing distributaries is considered to be an important measure for river restoration. These areas are the remnants of the former Rhine floodplain and the only area where habitat restoration is possible due to the river functions assigned. Secondary channel construction in the area called ‘Gamerensche Waarden’ was taken as an example to show effects of habitat restoration on the macroinvertebrate fauna. Totally 322 macroinvertebrate taxa were found during the monitoring period. During the first 3 years species richness in the area increased rapidly due to colonization processes in the channels following habitat development. After that period total number of taxa found in the channels stabilized at around 170. A clear positive relationship was demonstrated between habitat quality and species richness. Furthermore, the density of exotic species in the secondary channels was less than in the groyne fields of the main channel. The relatively low number of taxa in polluted habitats could be explained by the presence of the PCB 28 congener. Copyright © 2007 John Wiley & Sons, Ltd.     

Sleep and need for recovery in shift workers: do chronotype and age matter?

This study examined associations of chronotype and age with shift-specific assessments of main sleep duration, sleep quality and need for recovery in a cross-sectional study among N = 261 industrial shift workers (96.6% male). Logistic regression analyses were used, adjusted for gender, lifestyle, health, nap behaviour, season of assessment and shift schedule. Shift workers with latest versus earliest chronotype reported a shorter sleep duration (OR 11.68, 95% CI 3.31–41.17) and more awakenings complaints (OR 4.84, 95% CI 4.45–11.92) during morning shift periods. No associations were found between chronotype, sleep and need for recovery during evening and night shift periods. For age, no associations were found with any of the shift-specific outcome measures. The results stress the importance of including the concept of chronotype in shift work research and scheduling beyond the concept of age. Longitudinal research using shift-specific assessments of sleep and need for recovery are needed to confirm these results.

Practitioner Summary: Chronotype seems to better explain individual differences in sleep than age. In view of ageing societies, it might therefore be worthwhile to further examine the application of chronotype for individualised shift work schedules to facilitate healthy and sustainable employment.     

Performance of sol–gel Titanium Mixed Metal Oxide electrodes for electro-catalytic oxidation of phenol

Mixed metal oxides SnO₂–RuO₂–IrO₂, Ta₂O₅–IrO₂ and RhO₂–IrO₂ were immobilised on a Ti substrate using sol–gel techniques. The Ti mixed metal oxides were characterized in terms of morphology using scanning electron microscopy. Cyclic voltammetric responses of phenol at Ti/SnO₂–RuO₂–IrO₂, Ti/Ta₂O₅–IrO₂ and Ti/RhO₂–IrO₂ electrodes were evaluated and showed significantly low potentials for Ti/Ta₂O₅–IrO₂ (+100 mV), Ti/SnO₂–RuO₂–IrO₂ (+200 mV) and Ti/RhO₂–IrO₂ (−100 mV). The degradation of phenol in aqueous solution and its intermediates were investigated by bulk electrolysis and quantitatively assessed by HPLC analysis to elucidate the decomposition pathways and to develop a kinetic model for the electro-catalytic oxidation of phenol over Ti mixed metal oxides. Ring compounds, benzoquinone/hydroquinone, catechol, and short chain organics, carboxylic acids, have been identified as intermediate products for the electro-catalytic oxidation of phenol. Fundamental kinetic data were obtained for the conversion of phenol at these electrodes and was found to proceed in accordance with the pseudo-first-order kinetics with respect to the phenol concentration.     

Spurious signals in DQF spectroscopy: two-shot stimulated echoes

The most widely used technique for double-quantum filtered (DQF) single-voxel spectroscopy (SVS) is based on a symmetric PRESS sequence with two additional spatially unselective /2 pulses, one of which is usually frequency selective. The actual filtering, rejecting signals from all uncoupled resonances, can be done by suitable phase cycling of the rf pulses in successive shots, but in practice gradient filtering is always used. Under usual conditions the sequence repetition time is comparable to the spin-lattice relaxation time, and a stimulated echo is formed by five out of the ten rf pulses in two consecutive shots. This echo is not filtered out by the gradients, and additional phase cycling is needed to eliminate it. Its spatial origin is the full transverse slice selected by the last pulse of the PRESS sequence. The SVS shimming procedure may create an important field variation in this slice (outside the volume of interest VOI). Water singlet signals therefore appear in a band of frequencies other than 4.7 ppm, and remain unaffected by water suppression pulses. In practice phase-alternation schemes can reduce these spurious signals by several orders of magnitude, but even then they may mask the weak metabolite signals of interest. We describe a strategy to minimize these spurious signals and propose a 16-step phase cycling scheme that attenuates the stimulated echo in every two-step subcycle.     

Magnetic resonance imaging in patients with granulomatosis with polyangiitis (Wegener’s) and subglottic stenosis

Objective

To evaluate the ability of MRI to detect subglottic stenosis and to differentiate between active and inactive subglottic inflammation in patients with granulomatosis with polyangiitis (GPA).

Materials and methods

MRI studies of the larynx of 18 GPA patients with suspected SGS were included. The MRI protocol included T1- and T2-weighted and STIR-sequences, dynamic contrast enhancement (DCE) and diffusion weighted imaging (DWI). Two independent observers reviewed the MR images. SGS were identified and quantified, inflammatory activity was assessed using edema imaging, DCE and DWI. Final MRI diagnoses were compared to the clinical, laryngoscopic and histopathologic results.

Results

MRI confirmed SGS in all GPA patients with significant narrowing of the airway lumen and thickening of subglottic wall. Assessing the subglottic inflammatory activity, MRI showed a sensitivity of 87.5 % and a specificity of 60.0 %. Interrater agreement was κ = 0.769. Of the different MR technical approaches tested, edema imaging was most sensitive and specific. DWI led to significant differences in the apparent diffusion coefficient between active and inactive subglottic inflammation. No significant differences were found with DCE imaging.

Conclusion

MR imaging has shown the ability to detect and grade SGS in patients with GPA. It non-invasively assesses the status of inflammatory activity utilizing edema sensitive sequences and DWI.     

Physico-chemical and electrochemical characterization of Ti/RhOx–IrO2 electrodes using sol–gel technology

Sol–gel technology has been successfully used for the incorporation of RhO_x–IrO₂ on a Ti substrate. RhO_x–IrO₂ was prepared from chloride precursors of Rh and Ir, for surface studies. These metal oxides were then immobilised on solid Ti substrates via dip withdrawal coating methods to form thin films. The Ti/RhO_x–IrO₂ thin films were extensively characterized in terms of surface characterization and chemical composition and used in the oxidation of phenol. Thermo-gravimetric analysis (TGA) determined the calcination temperature at 700 °C where no further structural changes occurred due to mass loss. The rhodium oxide showed two-phase formations, RhO₂ and Rh₂O₃, which were attributed to high calcinated temperatures compare to one phase IrO₂ which was stable at lower temperatures. The scanning electron microscopy (SEM) showed that the morphology of the film was found to be rough with a grain-like appearance in the 150-nm range. The phase composition of these metal oxides was determined by X-ray diffraction (XRD) technique and found to have crystalline structures. The results obtained from Rutherford backscattering spectrometry (RBS) revealed information regarding the chemical composition of the metal oxides and confirmed the diffusion of Rh and Ir into the Ti substrate. Electrochemical characterization of the Ti/RhO_x–IrO₂ electrode, via cyclic voltammetry (CV), showed distinctive redox peaks: anodic and cathodic peaks associated with the oxidation and reduction of the ferricyanide–ferrocyanide couple was seen at 250 and 100 mV respectively; the peak observed at 1000 mV was associated with oxygen evolution and a broad reductive wave at −600 mV can be ascribed to the Ti/RuO_x–IrO₂ reduction, which proved that the Ti/RhO_x–IrO₂ electrode were electroactive and exhibit fast electrochemistry.     

Microstructuring of stainless steel implants by electrochemical etching

The effects of electrochemically enhanced etching on stainless steel coronary stent surfaces have been investigated in respect to their applicability as surface modifications prior drug-coating. Two methods have been investigated, one basing on grain boundary etching with diluted HNO₃ and the other one on hydrochloric acid etching. The etching current was in the range of 30–200 mA which accounts for 0.34–2.28 mA/mm2 surface. Grain boundary etching produced a micro-furrowed surface providing volume for the coating drug. The theoretical volume offered by the furrows was calculated on the basis of laser perthometry and was determined to be 0.146 mm3/cm2. With the hydrochloric acid etching method it was possible to generate an evenly rough, terraced surface. Both surfaces have been coated with Rapamycin in ethanol (20 mg/mL) and examined under SEM after dilatation. It was shown that a uniform drug layer is maintained after dilatation of the stent and little flaking is visible. Quantification of the amount of Rapamycin yielded 21.4 μg/mm2 for the electropolished stents, 36.6 μg/mm2 for the grain-boundary etched stents and 27.7 μg/mm2 for the hydrochloric acid etching after dilatation. For the grain boundary etched stents an improved drug adhesion was found, while the hydrochloric acid etchings resulted in a deterioration of the adhesion properties.     

Low wind speed turbines and wind power potential in Minnesota, USA

Wind power development in Minnesota largely has been focused in the “windy” southwestern part of the state. This research evaluates the additional power that potentially could be generated via low wind speed turbines, particularly for areas of the state where there has been comparatively little wind energy investment. Data consist of 3 years (2002–2004) of wind speed measurements at 70–75 m above ground level, at four sites representing the range of wind speed regimes (Classes 2–5) found in Minnesota. Power estimates use three configurations of the General Electric 1.5-MW series turbine that vary in rotor diameter and in cut-in, cut-out, and rated speeds. Results show that lower cut-in, cut-out, and rated speeds, and especially the larger rotor diameters, yield increases of 15–30% in wind power potential at these sites. Gains are largest at low wind speed (Class 2) sites and during the summer months at all four sites. Total annual wind power at each site shows some year-to-year variability, with peaks at some sites partially compensating for lulls at others. Such compensation does not occur equally in all years: when large-scale atmospheric circulation patterns are strong (e.g., 2002), the four sites show similar patterns of above- and below-average wind power, somewhat reducing the ability of geographic dispersion to mitigate the effects of wind speed variability.