Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers

Nanoparticles can be used to improve the delivery of many drugs, especially peptides and proteins. Although several methods are available for polymeric nanoparticle preparation, there are few single-stage processes that produce dry, solid nanoparticles that can be easily re-dispersed in pharmaceutical vehicles. The aerosol flow reactor method is a single-stage process that has been used for the preparation of multicomponent, coated nanoparticles under uniform temperature and gas flow field. However, it is traditionally used with high synthesis temperatures. In the present study, the aerosol flow reactor method was further optimized for processing and surface stabilization of pharmaceutical nanoparticles containing temperature sensitive biomolecules. In the developed method, drug-loaded carrier nanoparticles consisting of a biodegradable polymer (Eudragit L100) and a drug (phenylephrine hydrochloride) were first produced by aerosol droplet drying and subsequently coated in the gas phase. The carrier particles were coated with l-leucine in order to inhibit agglomeration of the nanoparticles in solutions before administration. In the coating process, a side stream of l-leucine vapor was directed into the main aerosol flow containing the drug-loaded carriers. The mixing with the main flow at ambient temperature induced a supersaturation of l-leucine vapor and condensation on the carrier particles. The results demonstrate that solid, hydrodynamically stable drug-loaded polymeric nanoparticles can be produced with a thin l-leucine coating. The low process temperature enables the surface engineering of particles loaded with temperature sensitive drugs or bioactive materials to be utilized for drug delivery purposes.     

The effect of process parameters on the hardness of surface densified Scots pine solid wood

This paper addresses the effect of surface densification on the Brinell hardness of Scots pine sapwood. Densification was performed in an open system under heat and compression using different compression temperatures and closing times. The hardness was measured using a modified Brinell hardness method. Furthermore, the density profiles of the samples were measured and their correlation to hardness analysed. It was found that the process parameters strongly affected the hardness of surface densified solid wood. This knowledge is relevant when optimising the densification process according to the properties required of the end-product. At 150 °C compression temperature and 0.5 min closing time, the average Brinell hardness (23.4 N/mm²) was double to that at 200 °C and 5 min closing time (11.6 N/mm²).     

Reducing the set-recovery of surface densified solid Scots pine wood by hydrothermal post-treatment

The mechanical properties of wood surface are of particular interest in applications where mainly the surface is exposed to use, such as flooring boards. Wood surface densification aims to improve these properties by compressing only the first few millimeters beneath the surface. Scots pine (Pinus sylvestris L.) sapwood was surface densified to three degrees of compression at 150 °C using a specially designed heated press. Half of the specimens were hydrothermally post-treated at 200 °C. To study the influence of the degree of compression and hydrothermal post-treatment on the set-recovery, specimens were subjected to water soaking-drying-cycles. The surface densification process resulted in a minor mass loss regardless of the degree of compression, whilst the hydrothermal post-treatment led to an average mass loss of 3.8 % in surface densified specimens and of 4.1 % in control un-densified specimens. Furthermore, considerable fixation of compressive deformation was obtained by hydrothermal post-treatment at 200 °C.     

Visualization of Trunk Muscle Synergies During Sitting Perturbations Using Self-Organizing Maps (SOM)

The purpose of this study was to demonstrate the use of the self-organizing map (SOM) method for visualization, modeling, and comparison of trunk neuromuscular synergies during perturbed sitting. Thirteen participants were perturbed at the level of the sternum, in eight directions during sitting. Electromyographic (EMG) responses of ten trunk muscles involved in postural control were recorded. The SOM was used to encode the EMG responses on a 2-D projection (i.e., visualization). The result contains similar patterns mapped close together on the plot therefore forming clusters of data. Such visualization of ten EMG responses, following eight directional perturbations, allows for comparisons of direction-dependent postural synergies. Direction-dependent neuromuscular response models for each muscle were then constructed from the SOM visualization. The results demonstrated that the SOM was able to encode neuromuscular responses, and the SOM visualization showed direction-dependent differences in the postural synergies. Moreover, each muscle was modeled using the SOM-based method, and derived models showed that all muscles, except for one, produced a Gaussian fit for direction-dependent responses. Overall, SOM analysis offers a reverse engineering method for exploration and comparison of complex neuromuscular systems, which can describe postural synergies at a glance.     

Silane-crosslinking of recycled low-density polyethylene/wood composites

The aim of this work was to study silane-crosslinking of recycled low-density polyethylene wood composites and its effect on composites properties. The composites were produced in a one-step twin-screw extrusion process and the silane–peroxide solution was pumped into the extruder. Degree of crosslinking, mechanical properties, short-term creep, fractured surfaces and nature of crosslinking were studied to understand the relationship between composite structure and properties. The results showed that crosslinked composite strength, toughness and creep resistance were improved compared to uncrosslinked composites. The flexural strength was doubled compared to uncrosslinked samples and the creep strain was reduced. The crosslinked composites stored under room conditions showed the highest strength, whereas storage in a sauna resulted in a higher degree of crosslinking. The Fourier transform infrared spectroscopy indicated formation of silane-bridges between wood and polyethylene, accordingly improving the interfacial adhesion between the wood and LDPE. The low concentration of peroxide in the silane-solution was shown to be a preferred composition to limit unintentional crosslinking during the process.     

The influence of fibre microstructure on fibre breakage and mechanical properties of natural fibre reinforced polypropylene

The aim of the study was to investigate the influence of fibre morphology of different natural fibres on the composites mechanical properties and on the fibre breakage due to extrusion process. The composite materials were manufactured using LTF (long fibre thermoplastic) extrusion and compression moulding and the used fibres were sisal, banana, jute and flax, and the matrix was a polypropylene. The results showed that sisal composites had the best impact properties and the longest fibres after the extrusion. Generally, the composites flexural stiffness was increased with increased fibre content for all fibres, being highest for flax composites. The flexural strength was not affected by the addition of fibres because of the low compatibility. The addition of 2 wt.% maleated polypropylene significantly improved the composites properties. Unlike the other three fibres, flax fibres were separated into individual elementary fibres during the process due to enzymatic retting and low lignin content.     

Adverse consequences of access to individuals’ information: an analysis of perceptions and the scope of organisational influence

Organisations are highly interested in collecting and analysing customer data to enhance their service offerings and customer interaction. However, individuals increasingly fear how such practices may negatively affect them. Although previous studies have investigated individuals’ concerns about information privacy practices, the adverse consequences people associate with external actors accessing their personal information remain unclear. To mitigate customers’ fears, organisations need to know which adverse consequences individuals are afraid of and how to address those negative perceptions. To investigate this topic, we conducted 22 focus groups with 119 participants. We developed a comprehensive conceptualisation and categorisation of individuals’ perceived adverse consequences of access to their information that includes seven types of consequences: psychological, social, career-related, physical, resource-related, prosecution-related, and freedom-related. Although individuals may limit their interactions with an organisation owing to consequences they associate with both the organisation and other actors, organisations can apply preventive and corrective mechanisms to mitigate some of these negative perceptions. However, organisations’ scope of influence is limited and some fears may be mitigated only by individuals themselves or government regulation, if at all.     

Active video game head movement inputs

Virtual reality has been extensively studied for applications in rehabilitation. With the development of active video games, these commercial products can also be considered for inclusion in a patient’s rehabilitation program. In this study, the Sony EyeToy ^® and PlayStation 2 ^® were used with the AntiGrav? game to evaluate the user’s head movement actions. The game required lateral head, body, and arm movements. Over the course of 9 sessions of game play, average and maximum head excursions remained constant. However, the frequency of head movement increased over the sessions. The results suggest that the video game could be used for postural balance rehabilitation through head movements, and their effect on the vestibular system. Future work will evaluate how such vestibular exercise, and an increase in head movement frequency over training sessions can support postural balance improvements.