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941.
Collins W. Andrew; Maccoby Eleanor E.; Steinberg Laurence; Hetherington E. Mavis; Bornstein Marc H. 《Canadian Metallurgical Quarterly》2000,55(2):218
Current findings on parental influences provide more sophisticated and less deterministic explanations than did earlier theory and research on parenting. Contemporary research approaches include (a) behavior-genetic designs, augmented with direct measures of potential environmental influences; (b) studies distinguishing among children with different genetically influenced predispositions in terms of their responses to different environmental conditions; (c) experimental and quasi-experimental studies of change in children's behavior as a result of their exposure to parents' behavior, after controlling for children's initial characteristics; and (d) research on interactions between parenting and nonfamilial environmental influences and contexts, illustrating contemporary concern with influences beyond the parent–child dyad. These approaches indicate that parental influences on child development are neither as unambiguous as earlier researchers suggested nor as insubstantial as current critics claim. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
942.
Simon Vlad Luca Katarzyna Gawe-Bben Marcelina Strzpek-Gomka Ainur Jumabayeva Zuriyadda Sakipova Jianbo Xiao Laurence Marcourt Jean-Luc Wolfender Krystyna Skalicka-Wo
niak 《International journal of molecular sciences》2021,22(19)
Ferula penninervis Regel & Schmalh. is a perennial plant used in Kazakh traditional folk medicine to treat epilepsy, neurosis, rheumatism, gastroduodenal ulcers, dyspepsia, wounds, abscesses or tumors. The aim of this work was to isolate series of sesquiterpene lactones from a crude methanolic root extract and investigate their in vitro cytotoxic potential against androgen-dependent prostate cancer LNCaP and epithelial prostate PNT2 cells, as well as to evaluate their melanin production inhibitory effects in murine melanoma B16F10 cells stimulated with α-melanocyte-stimulating hormone (αMSH). Two new (penninervin P and penninervin Q) and five known (olgin, laferin, olgoferin, oferin and daucoguainolactone F) guaiane-type sesquiterpene lactones were isolated with the use of a simple and fast liquid-liquid chromatography method. Olgin and laferin showed the most promising cytotoxic effects in LNCaP cells (IC50 of 31.03 and 23.26 μg/mL, respectively). Additionally, olgin, laferin, olgoferin, and oferin (10 μg/mL) potently impaired melanin release (40.67–65.48% of αMSH + cells) without influencing the viability of B16F10 cells. In summary, our findings might indicate that guaiane-type sesquiterpene lactones from F. penninervis could be regarded as promising candidates for further research in discovering new therapeutic agents with anti-prostate cancer and skin depigmentation properties. 相似文献
943.
Jae Youn Kim W. Curt Conner Robert L. Laurence 《Korean Journal of Chemical Engineering》1998,15(3):262-272
The control of polymer particle size and PSD is of industrial importance. Very fine particles pack poorly, thereby limiting
reactor capacity, and present a dust explosion hazard. In olefin polymerization, a particle size distribution (PSD) in the
polymerization reactor has been derived using population balances. Three reasonable reaction mechanisms for Ziegler-Natta
catalysts, i.e., a simple reaction model, an active site reduction model, and a two sites model, have been used to derive
the average number of active sites. It was observed that the PSD depends not only on residence time, but also on the reaction
mechanism. It was also found that multiple active sites change the PSD slightly. The PSD, however, does not depend on initial
catalyst volume. 相似文献
944.
Jae Youn Kim W. Curt Conne Robert L. Laurence 《Korean Journal of Chemical Engineering》1998,15(2):164-176
Mass and energy balances in a reactor have been derived to study the effect of particle size distribution (PSD) for each reaction
mechanism on the reactor dynamics. It was observed that the PSD affects both bed height and particle volume. A feasible region
for reactor operation has been calculated by using physical constraints. In a nonisothermal polymerization system, the reactor
temperature does not change appreciably as catalyst injection rate increases. A unique steady state solution is found in a
gas-phase continuous stirred-bed propylene polymerization reactor. The eigenvalues of the system of equations indicate that
the steady state is unstable. A comparison with published data allows the observation that the actual reactor dynamics may
be readily explained by using only the PSD derived from a simple reaction mechanism. 相似文献
945.
My Le Quach Laurence D Melton Philip J Harris Jeremy N Burdon Bronwen G Smith 《Journal of the science of food and agriculture》2001,81(3):311-318
The monosaccharide compositions of parenchyma cell walls of raw and cooked corms of taro, Colocasia esculenta cv Tausala Pink, were determined. The cell wall constituents were sequentially extracted using CDTA, Na2CO3, 1 M KOH, 4 M KOH and water to leave a final residue (α‐cellulose). The monosaccharide compositions of the cell walls and cell wall fractions from the raw and cooked corms were consistent with the presence in these cell walls of large amounts of cellulose and pectic polysaccharides. The monosaccharide composition of the cell walls of the raw corms resembled the monosaccharide compositions of primary cell walls of other non‐commelinoid monocotyledons and dicotyledons. Cooking of the corms resulted in alteration of the cell walls, with solubilisation of pectic polysaccharides occurring earlier in the sequential fractionation and possibly changes in the extractability of xyloglucans and/or xylans. © 2000 Society of Chemical Industry 相似文献
946.
Bruning M Kreplak L Leopoldseder S Müller SA Ringler P Duchesne L Fernig DG Engel A Ucurum-Fotiadis Z Mayans O 《Nano letters》2010,10(11):4533-4537
The development of biomatrices for technological and biomedical applications employs self-assembled scaffolds built from short peptidic motifs. However, biopolymers composed of protein domains would offer more varied molecular frames to introduce finer and more complex functionalities in bioreactive scaffolds using bottom-up approaches. Yet, the rules governing the three-dimensional organization of protein architectures in nature are complex and poorly understood. As a result, the synthetic fabrication of ordered protein association into polymers poses major challenges to bioengineering. We have now fabricated a self-assembling protein nanofiber with predictable morphologies and amenable to bottom-up customization, where features supporting function and assembly are spatially segregated. The design was inspired by the cross-linking of titin filaments by telethonin in the muscle sarcomere. The resulting fiber is a two-protein system that has nanopatterned peptide display capabilities as shown by the recruitment of functionalized gold nanoparticles at regular intervals of ~ 5 nm, yielding a semiregular linear array over micrometers. This polymer promises the uncomplicated display of biologically active motifs to selectively bind and organize matter in the fine nanoscale. Further, its conceptual design has high potential for controlled plurifunctionalization. 相似文献
947.
Sun L Chow LC Frukhtbeyn SA Bonevich JE 《Journal of research of the National Institute of Standards and Technology》2010,115(4):243-255
This study aimed at preparing and studying the properties of nanoparticles of calcium phosphate (nCaP) with Ca/P ratios ranging from 1.0 to 1.67 using a spray-drying technique. Micro-structural analyses suggested that the nCaPs with Ca/P ratios of 1.67 to 1.33 were nano-sized amorphous calcium phosphate (ACP) containing varying amounts of acid phosphate and carbonate. The nCaP with Ca/P ratio of 1 contained only nano-sized low crystalline dicalcium phosphate (DCP). BET measurements of the nCaPs showed specific surface areas of (12 ± 2 to 50 ± 1) m(2)/g, corresponding to estimated equivalent spherical diameters of (38 to 172) nm. However, dynamic light scattering measurements revealed much larger particles of (380 ± 49 to 768 ± 111) nm, owing to agglomeration of the smaller primary nano particles as revealed by Scanning Electron Microscopy (SEM). Thermodynamic solubility measurements showed that the nCaPs with Ca/P ratio of 1.33 - 1.67 all have similar solubility behavior. The materials were more soluble than the crystalline hydroxyapatite (HA) at pH greater than about 4.7, and more soluble than β-tricalcium phosphate (β-TCP), octacalcium phosphate (OCP) and DCP at pH above 5.5. Their solubility approached that of α-tricalcium phosphate (α-TCP) at about pH 7. These nCaPs, which cannot be readily prepared by other currently available methods for nanoparticle preparation, have potential biomedical applications. 相似文献
948.
Vazquez D Takagi S Frukhtbeyn S Chow LC 《Journal of research of the National Institute of Standards and Technology》2010,115(4):225-232
The bone defect repair functions of calcium phosphate cement (CPC) are related to its osteoconductivity and its gradual replacement by new bone. Adding mannitol to CPC may enhance its bone repair potential by increasing CPCs macroporosity and dissolution rate. The objective of the study was to assess microporosity and macroporosity and dissolution rates for CPC mixed with mannitol. Three groups of CPC discs were prepared by combining an equimolar mixture of tetracalcium phosphate and anhydrous dicalcium phosphate with (0 %, 10 %, or 50 %) mass fraction (hereafter expressed as mass %) of mannitol. Macroporosity and microporosity of the samples were calculated from volume and mass measurements of the discs. Discs were then placed in a pH 3.0 demineralizing solution simulating acidified physiological solution, and dissolution rates were measured by a previously described constant-composition titration method. Pure CPC exhibited no macropores and microporosity (mean ± s.d.; n = 5) of (46.8 ± 0.8) % volume fraction (hereafter expressed as vol %). Adding 10 mass % mannitol resulted in 15.6 ± 3.9 vol % macroporosity and 39.4 ± 1.8 vol % microporosity, and adding 50 mass % mannitol produced 54.7 ± 0.8 vol % macroporosity and 21.1 ± 0.4 vol % microporosity. The dissolution rates (mean ± s.d.; n = 5) of CPC with (0, 10, and 50) mass % mannitol incorporation were (30.6 ± 3.4, 44.8 ± 10.2, and 54.7 ± 3.6, respectively) μg · cm(-2) · min(-1), or (0.018 ± 0.002, 0.032 ± 0.007, and 0.072 ± 0.005, respectively) μL · cm(-2) · min(-1). Adding either 10 mass % or 50 mass % mannitol into CPC significantly (p < 0.05) increased CPC dissolution rates. Adding mannitol readily increased macroporosity and dissolution rate of CPC, which may enhance the capacity of CPC to be osteoconductive. 相似文献
949.
Temporal and spatial variation in sediment P composition and mobility were investigated in Loch Leven. Little change was observed in total sediment P (surface sediment at 4m depth), in comparison to a previous study (1990), despite significant reduction of external point sources of P. Labile P and residual P have both increased (0.007-0.039 mg PO(4)-P and 0.121-0.420 mg PO(4)-P per gram dry weight of sediment, respectively) since 1990. An analysis of P fractions, along a depth transect, indicated elevated labile P concentrations in shallow water sediment (<12 m overlying water depth). Regression analysis showed that spatial variability in reductant-adsorbed P was significantly related to sediment chlorophyll a concentration (R(2)=0.733, p<0.05). This may be linked to the production of oxygen, by benthic algae, resulting in the maintenance of an oxygenated layer at the sediment surface. Variation in labile P was best explained by overlying water temperature and equilibrium phosphate concentration (EPC0). 相似文献
950.
Cline Croutx‐Barghorn Olivier Soppera Laurence Simonin Daniel Joseph Lougnot 《Advanced functional materials》2000,10(1):25-38
Recent results have shown the interest in self‐developing photopolymers as optical storage materials. Their main advantage is the absence of a wet chemical post‐treatment to reveal the latent images. The self‐generating character of a sensitive layer is studied for the fabrication of refractive microlens arrays in the visible range. The kinetic of radical‐induced photopolymerization, the effect of molecular oxygen on the reaction rate and the properties of the final photopolymer are outlined. The results focus on the process of relief development and the role of atmospheric oxygen during the generation of refractive microlenses. A structural characterization of micro‐optical elements is investigated. Copyright © 2000 John Wiley & Sons, Ltd. 相似文献