Maximizing capacity,flexibility and efficiency in G-PON networks using VCSEL-based OOK and 2/4-PAM formats

This work experimentally demonstrates the potential of multi-level pulse amplitude modulation with direct detection to maximize carrier spectral efficiency and double the Gigabit passive optical networks (G-PON) network data rate. Three scenarios have experimentally been exploited. First, a 1310?nm vertical surface-emitting laser (VCSEL) has directly been modulated with a 10?Gbps OOK data. A receiver sensitivity of ?19.11?dBm is attained, and a successful error free transmission over 22?km SMF fibre achieved, with a transmission penalty of 0.46?dB. To maximize carrier spectral efficiency, 2/4 PAM modulation formats are adopted respectively. A receiver sensitivity of ?14.64 and ?11.63?dBm is attained for 2-PAM and 4-PAM formats respectively. However, a 3.21?km fibre transmission introduces a penalty of 0.64 and 3.30?dB for 2-PAM and 4-PAM formarts respectively. 2/4-PAM modulation formats significantly increase the aggregated data rate at different ONUs within the G-PON without expensive optics investment, though at the cost of reduced transmission reach due to the high bitrate attained. We further demonstrate the design of a software defined digital signal processing assisted receiver to recover the 2/4 PAM transmitted signal without employing costly receiver hardware.     

Accounting-based heuristics for order processing and review in a stochastic environment

As manufacturers evolve from make-to-stock to make-to-order strategies, they are forced to rely less on inventory to meet demands and more on the effective usage of existing capacity as they determine which orders to accept and schedule. Several accounting-based heuristics are used to identify and accept those jobs that maximize plant throughput. Accounting heuristics have been suggested as surrogates for approximating the opportunity costs of manufacturing one order instead of another order. Research results suggest that the best heuristic is dependent on the balance of the manufacturing resources. Moreover, these tendencies are affected by product mix and load.     

A high capacity data centre network: simultaneous 4-PAM data at 20 Gbps and 2 GHz phase modulated RF clock signal over a single VCSEL carrier

Optical fibre communication technologies are playing important roles in data centre networks (DCNs). Techniques for increasing capacity and flexibility for the inter-rack/pod communications in data centres have drawn remarkable attention in recent years. In this work, we propose a low complexity, reliable, alternative technique for increasing DCN capacity and flexibility through multi-signal modulation onto a single mode VCSEL carrier. A 20 Gbps 4-PAM data signal is directly modulated on a single mode 10 GHz bandwidth VCSEL carrier at 1310 nm, therefore, doubling the network bit rate. Carrier spectral efficiency is further maximized by modulating its phase attribute with a 2 GHz reference frequency (RF) clock signal. We, therefore, simultaneously transmit a 20 Gbps 4-PAM data signal and a phase modulated 2 GHz RF signal using a single mode 10 GHz bandwidth VCSEL carrier. It is the first time a single mode 10 GHz bandwidth VCSEL carrier is reported to simultaneously transmit a directly modulated 4-PAM data signal and a phase modulated RF clock signal. A receiver sensitivity of ?10. 52 dBm was attained for a 20 Gbps 4-PAM VCSEL transmission. The 2 GHz phase modulated RF clock signal introduced a power budget penalty of 0.21 dB. Simultaneous distribution of both data and timing signals over shared infrastructure significantly increases the aggregated data rate at different optical network units within the DCN, without expensive optics investment. We further demonstrate on the design of a software-defined digital signal processing assisted receiver to efficiently recover the transmitted signal without employing costly receiver hardware.     

Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk

OBJECTIVE: To assess the factors that predict operative mortality after intestinal infarction, and show what effect referral patterns have on mortality. DESIGN: Retrospective study. SETTING: Two university departments of surgery, France. SUBJECTS: 144 patients with intestinal infarctions operated on between January 1980 and August 1995. INTERVENTIONS: Univariate and multivariate analyses. MAIN OUTCOME MEASURES: Operative mortality and the factors associated with it. RESULTS: Operative mortality was 67% (96/144) during the first 45 days postoperatively. The univariate analysis showed that age over 75 years (p=0.0002), female sex (p=0.007), the presence of shock (p < 0.0001), and referral from cardiovascular medical or surgical unit (p=0.01) were significantly associated with mortality. However, the multivariate analysis reduced these to extent of infarction (p=0.0001), the presence of shock (p=0.0002), age over 75 years (p=0.0001), and recent cardiac or vascular operation (p=0.03). CONCLUSIONS: The influence of referral pattern was related to previous cardiac or vascular operation, and the risk among women to the fact that their age was 10 years older than that of men. This study shows how the type of referral may explain the wide variations in reported mortality. To compare published series, care should be taken to avoid any selection bias.     

Synergic antistaphylococcal properties of lactoferrin and lysozyme

Staphylococcus epidermidis colonises a wide range of implanted prosthetic devices, but rarely contact lenses -- despite a similarity in material composition. A conceivable explanation for this anomaly is the action of the tear defences, including the constitutive proteins lactoferrin and lysozyme. Therefore this study investigated the effect of lactoferrin, lysozyme and serum on the growth of S. epidermidis isolates in artificial tear fluid. Whether supplemented with serum alone or serum with either apolactoferrin or lysozyme, this medium induced a similar, strain-variable effect. However, simultaneous addition of these proteins induced a greater bactericidal or bacteristatic effect. Of those strains killed by the concerted action of apolactoferrin and lysozyme, the absence of serum led to a further increase in the bactericidal effect, whereas strains displaying bacteriostasis were unaffected by serum. Iron saturation of lactoferrin reversed the antimicrobial synergy of apolactoferrin and lysozyme. These results show synergy between lactoferrin and lysozyme which is dependent on the iron limitation of lactoferrin. As a bactericidal mechanism, this synergy is augmented by serum, but bacteriostasis remains unaffected by serum supplemention. Thus, the combination of lysozyme and lactoferrin may partly explain the low level of contact lens colonisation by S. epidermidis in vivo.     

Human cholesterol synthesis measurement using deuterated water. Theoretical and procedural considerations

Creation of a dynamic levator aponeurosis fold or double eye adds to the beauty of the East Asian. The eyes are larger and less puffy, and the eyelashes appear longer and curve up and out instead of down. The distance from the ciliary border to the eyebrow is decreased and more in proportion. The Mongolian trait is preserved.