Moisture Transfer Tests in Blister Package Testing

Lactose and dicalcium phosphate tablets have been made by six different manufacturing-methods. These two types of tablet were packaged in blister packs and subjected to accelerated moisture tests. Methods are described whereby the diffusion coefficient of the blister film can be calculated from the moisture absorption curves. It is shown that the excipient effect (plasticizer) in the film increases the diffusion coefficient by at least an order of magnitude over and above the pure polymer. It is shown that, except for extruded granules, tablets made by the various methods exhibited approximately the same moisture absorption characteristics. The effects of this absorption on the hardness of the tablets are variable and demonstrate the necessity of adapting the formula and the manufacturing procedure to the particular blister.     

The protective effect of antioxidants to a phototoxin-sensitive insect herbivore,Manduca sexta

Photo-activated plant secondary compounds have been shown to be toxic to many organisms including insects. Insect defenses include behavioral mechanisms such as light avoidance, as well as specific biochemical defenses such as antioxidants and antioxidant enzymes. These antioxidant defenses eliminate or quench the deleterious singlet oxygen and free radicals formed by these phototoxins. In this paper we examined the role of dietary antioxidants in protecting the phototoxin-sensitive insect herbivoreManduca sexta. Elevated dietary levels of the lipid-soluble antioxidants-carotene and vitamin E resulted in a concentration-dependent reduction in the mortality associated with treatment ofM. sexta larvae with the phototoxic thiophene-terthienyl. Elevated levels of dietary ascorbic acid had no effect, whereas reduced levels greatly increased the toxicity of-terthienyl. Tissue levels of antioxidants were shown to increase substantially in larvae fed antioxidant-supplemented diets. The results suggest that the ability to absorb and utilize plant-derived antioxidants could be an important defense against photo-activated plant secondary compounds and may have allowed some insects to exploit phototoxic plants.     

Magnetic resonance imaging at 9.4 T: the Maastricht journey

The 9.4 T scanner in Maastricht is a whole-body magnet with head gradients and parallel RF transmit capability. At the time of the design, it was conceptualized to be one of the best fMRI scanners in the world, but it has also been used for anatomical and diffusion imaging. 9.4 T offers increases in sensitivity and contrast, but the technical ultra-high field (UHF) challenges, such as field inhomogeneities and constraints set by RF power deposition, are exacerbated compared to 7 T. This article reviews some of the 9.4 T work done in Maastricht. Functional imaging experiments included blood oxygenation level-dependent (BOLD) and blood-volume weighted (VASO) fMRI using different readouts. BOLD benefits from shorter T₂* at 9.4 T while VASO from longer T₁. We show examples of both ex vivo and in vivo anatomical imaging. For many applications, pTx and optimized coils are essential to harness the full potential of 9.4 T. Our experience shows that, while considerable effort was required compared to our 7 T scanner, we could obtain high-quality anatomical and functional data, which illustrates the potential of MR acquisitions at even higher field strengths. The practical challenges of working with a relatively unique system are also discussed.

     

Robust encryption method based on AES-CBC using elliptic curves Diffie–Hellman to secure data in wireless sensor networks

Wireless Networks - Secure data is a foremost topic in wireless sensor networks since data are transmitted through wireless channels where attackers may get access to critical information....     

Assessment of the bacteriological quality and nitrate pollution risk of Quaternary groundwater in the southern part of Abidjan District (Côte d’Ivoire)

In this study, total coliforms, thermotolerant coliforms, Escherichia coli and groundwater nitrate concentration were monitored at 127 groundwater sampling points (only 62 water points for bacteriological parameters) located in the southern part of Abidjan District. Each water sampling location was sampled in March and July 2007, representing respectively the long dry season and the long wet season. Geostatistical methods were used to analyze the spatial variability of nitrates and the groundwater nitrate pollution risk. The maximum seasonal content of total coliforms and thermotolerant coliforms ranged from 400 to 1000 CFU/100 mL and from 200 to 500 CFU/100 mL respectively. Moreover, 94% of these locations presented traces of bacteriological contamination. This contamination was mainly recorded during the rainy period. The degree of correlation between bacterial abundance and chemical parameters is variable. Nitrites, ammonium and potassium favoured coliform abundance. In the 127 water points, groundwater nitrate concentrations ranged from 4 to 198 mg L^?1 and were log-normally distributed in the study area. The groundwater contamination risk map indicated that the strongly urbanized west side of the site presented a high probability of exceeding the WHO drinking water standard (50 mg L^?1NO₃^?).     

Are standard wastewater treatment plant design methods suitable for any municipal wastewater?

The design and operational parameters of an activated sludge system were analyzed treating the municipal wastewaters in Istanbul. The design methods of ATV131, Metcalf & Eddy together with model simulations were compared with actual plant operational data. The activated sludge model parameters were determined using 3-month dynamic data for the biological nutrient removal plant. The ATV131 method yielded closer sludge production, total oxygen requirement and effluent nitrogen levels to the real plant after adopting correct influent chemical oxygen demand (COD) fractionation. The enhanced biological phosphorus removal (EBPR) could not easily be predicted with ATV131 method due to low volatile fatty acids (VFA) potential.     

Metaheuristics for the traveling salesman problem with pickups, deliveries and handling costs

This paper studies the Traveling Salesman Problem with Pickups, Deliveries, and Handling Costs. The subproblem of minimizing the handling cost for a fixed route is analyzed in detail. It is solved by means of an exact dynamic programming algorithm with quadratic complexity and by an approximate linear time algorithm. Three metaheuristics integrating these solution methods are developed. These are based on tabu search, iterated local search and iterated tabu search. The three heuristics are tested and compared on instances adapted from the related literature. The results show that the combination of tabu search and exact dynamic programming performs the best, but using the approximate linear time algorithm considerably decreases the CPU time at the cost of slightly worse solutions.     

The role of perceived organizational support,distributive justice and motivation in reactions to new information technology

Despite tremendous investments in information technology (IT), many technological interventions in organizations fail because employees do not fully accept and use IT. The present study explored how perceived organizational support and distributive justice affect employee reactions to new IT from a motivational point of view. Self-determination theory was used to understand how different motivational styles, varying in degree of self-determination, mediate the relationship of perceived organizational support and distributive justice with reactions to new IT. Results showed that perceived organizational support and distributive justice were associated with intrinsic and identified motivation to use the IT, but only POS was related to enjoyment and acceptance of the IT. Intrinsic and extrinsic motivation were both associated with IT usage, but IT usage was associated with enjoyment and acceptance only when people were intrinsically motivated. Intrinsic motivation also mediated the effects of POS on enjoyment and acceptance. Moreover, intrinsically motivated users were less likely to use a paper-based appointment booking alternative than those who were not. Implications for managing IT implementations are discussed.