Simulation Analysis of the Heat Transfer Performance of an N-type Microchannel Heat Exchanger

A microchannel heat exchanger with a triangular wave and symmetrical triangular wave structure was proposed in this paper. In addition, a new N-type microchannel heat exchanger was developed to balance the heat transfer performance and pressure drop. The relationship between different configurations of the N structure of the microchannel and the heat transfer performance was analyzed. The results showed that, at a high inlet flow rate, the symmetrical triangular wave microchannel had the best heat transfer performance, followed by the triangular wave microchannel and the straight channel. At the same flow rate, the degree of disturbance of the fluid was highest in the symmetrical N-structure microchannel, and an excellent heat transfer effect was observed.     

食物成瘾的研究进展及启示

食物成瘾是一种复杂的慢性疾病，导致人们在日常生活中对某种食物产生过度依赖与过度进食等相关行为特征，近年来已被认为是影响欧美发达国家肥胖症、暴食症、糖尿病等发病率持续升高的关键原因，引起学术界的极大关注，成为研究热点。本文主要介绍食物成瘾的概念、诊断标准，综述了食物成瘾的病理机制、影响因素和应对措施等方面的研究进展，并探讨食物成瘾对我国食品界的启示，为预防食物成瘾，保障公众健康提供有益借鉴。     

基于综合用电煤耗的电力高质量发展评价指标研究及应用

煤电平均供电煤耗作为评价能源系统效率的指标已在行业内广泛应用。但该项指标无法很好地反映一个国家、地区的用电结构与用电能耗水平。为此，参照行业内普遍采用的火电厂发电煤耗和供电煤耗指标，定义“综合用电煤耗”，即用户每用1 kW?h电“消耗”的标准煤量（单位:g/(kW?h)）。在此基础上，提出“综合发电煤耗”与“综合供电煤耗”的概念，形成完整的指标评价体系。对近年典型省份指标值的研究表明，该指标体系能够很好地反映供给侧国家、省区或企业的发电结构与电能生产能耗水平。这一指标体系能够为正确理解和计算用电、输电与电能替代项目的化石能源消耗量及其排放量提供依据。     

Supramolecular Glyco‐nanoparticles Toward Immunological Applications

Glyco‐mimicking nanoparticles (glyco‐NPs) with Förster resonance energy transfer (FRET) donor and acceptor groups formed via dynamic covalent bond of benzoboroxole and sugar from two complementary polymers are prepared. The glyco‐NPs are proved to be quite stable under physiological conditions but sensitive to pH. So the glyco‐NPs can be internalized by dendritic cells with integrity and nontoxicity and then dissociate within the acidic organelles. This particle dissociation is directly observed and visualized in vitro, for the first time via the FRET measurements and fluorescent microscopy. This feature makes controlled release of drug or protein by glyco‐NPs possible, i.e., when model antigen Ovalbumin is loaded in the glyco‐NPs, the released Ovalbumin in dendritic cells stimulates T cells more efficiently than the free Ovalbumin itself as a result of the enhanced antigen processing and presentation. Thus, the results enlighten a bright future of the glyco‐NPs in immunotherapy.     

低碳时变城配送车辆路径-发车调度集成优化

针对交通拥挤环境下日益增长的城市配送需求，通过分析时序依赖对成本和碳排放的影响，引入车辆在节点等待和离散调度策略，研究基于时序依赖的低碳城市配送车辆路径与离散调度问题。为求解该问题，设计基于遗传算法与局部搜索相结合的混合进化搜索算法对模型求解，用积极的局部搜索机制替代随机的变异操作，并通过可行解构造算法、变概率交叉和多种局部搜索策略来提高算法求解质量和求解效率。通过对比仿真实验对算法和模型的有效性进行了验证。     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.     

Effect of an abrupt change in pulling rate on microstructures of directionally solidified Al2O3-Er3Al5O12 eutectic and off-eutectic composite ceramics

Directionally solidified microstructures of Al₂O₃-Er₃Al₅O₁₂ eutectic and off-eutectic in situ composite ceramics were explored under abrupt-change pulling rate conditions. Corresponding temperature distributions and interface locations were studied. In eutectic composition, fluctuation of eutectic spacing occurred when the pulling rate increased abruptly. A gradually increase or abrupt increase in eutectic spacing was observed when the pulling rate decreased abruptly. In hypoeutectic and hypereutectic compositions, formation of the primary phases were suppressed when the pulling rate increased abruptly from 10?µm/s to 100?µm/s, while primary phases precipitated when the pulling rate decreased abruptly from 100?µm/s to 10?µm/s. The interface altitude decreased after the pulling rate increased abruptly, but increased after the pulling rate decreased abruptly. The liquid composition restriction (around the eutectic composition) at the eutectic interface plays an important role in the suppression of the primary dendrite and coupled eutectic oxides can be obtained in off-eutectic compositions even under higher solidification rate conditions.