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211.
Robert E. Mann Evelyn R. Vingilis Douglas Gavin Edward Adlaf Lise Anglin 《Accident; analysis and prevention》1991,23(6):483-491
While a major response to the drinking-driving problem has been to increase penalties for drinking-driving offences, the impact of sentence severity on the driving behaviour of offenders (specific deterrence) remains unclear. In this research, relationships between aspects of sentence severity (licensedeterrence) suspension, fine, jail term, assignment to probation, or temporary absence programmes) and postconviction accidents and drinking-driving convictions were examined, while controlling statistically for demographic and previous driving record factors. License suspensions were consistently associated with traffic safety benefits. However, increasing severity of other aspects of punishment seemed unrelated to outcome or was associated with increased traffic safety problems. As well, important differences between first, second, and multiple offenders were observed, which may be related to the impact of different aspects of sentence severity on driving behaviour. 相似文献
212.
Annemarie Olsen Christian Ritz Lise W. Kraaij Per Møller 《Food quality and preference》2012,23(2):90-98
This study investigated effects on vegetable liking and intake gained from exposing children to snack vegetables of different liking levels. In total, 345 9–11-year-old children participated. The intervention consisted of two exposure periods. First, children were either exposed to a neutrally liked vegetable (cauliflower), a mixture of a neutrally liked and a liked (sugar snap peas) vegetable, or a mixture of a neutrally liked and a disliked (celery) vegetable. In the second, period all children were served all vegetables. Intake of individual vegetables was measured daily. Liking was assessed before and after exposures and at a subsequent follow-up. Liking for most vegetables decreased during the exposure periods but tended to recover somewhat during follow-up. Intake of all vegetables was either stable or decreased during the intervention, no increases were observed. Intake levels depended on type of vegetable servings: When served with a liked vegetable, children consumed more of a neutrally liked vegetable than when served alone (p = 0.0005) or together with a disliked vegetable (p = 0.005). 相似文献
213.
Structured machine learning: the next ten years 总被引:4,自引:1,他引:3
Thomas G. Dietterich Pedro Domingos Lise Getoor Stephen Muggleton Prasad Tadepalli 《Machine Learning》2008,73(1):3-23
The field of inductive logic programming (ILP) has made steady progress, since the first ILP workshop in 1991, based on a balance of developments in theory, implementations and applications. More recently there has been an increased emphasis on Probabilistic ILP and the related fields of Statistical Relational Learning (SRL) and Structured Prediction. The goal of the current paper is to consider these emerging trends and chart out the strategic directions and open problems for the broader area of structured machine learning for the next 10 years. 相似文献
214.
Boudia N Halley R Kennedy G Lambert J Gareau L Zayed J 《The Science of the total environment》2006,366(1):143-147
Methylcyclopentadienyl manganese tricarbonyl (MMT) is an organic derivative of manganese (Mn), used since 1976 in Canadian gasoline as an octane enhancer. Its combustion leads to the emission of Mn particles. Several studies carried out by our research group have established a correlation between atmospheric Mn concentrations and automobile traffic density, suggesting that MMT in gasoline could play a significant role. This study aims to measure Mn concentrations in the air of the underground subway in Montreal (Canada) and to examine the relation with nearby surface automobile traffic density and, by extension, with the use of MMT in gasoline. Three subway stations were chosen for their location in different microenvironments with different traffic densities. Respirable (MnR<5 microm) and total Mn (MnT) were sampled over two weeks, 5 days/week, 12 h/day. For the station located in the lower traffic density area, relatively low levels of MnR and MnT were found, with averages of 0.018 and 0.032 microg/m(3), respectively. These concentrations are within the range of the background levels in Montreal. For the other two stations, the average concentrations of MnR were twice as high and exceeded the US EPA reference concentration of 0.05 microg/m(3). Although there may be several sources of Mn from different components of the subway structure and vehicles, no correlation was found between subway traffic and atmospheric Mn in the subway. Since the air in the underground subway is pumped directly from outside without filtration, our findings strongly suggest that the combustion of MMT in automobiles is an important factor. 相似文献
215.
The aim of the present study was to investigate the hepatic regulation and β-oxidation of long-chain fatty acids in peroxisomes and mitochondria, after 3-thia- tetradecylthioacetic acid (C14-S-acetic acid) treatment. When palmitoyl-CoA and palmitoyl-l-carnitine were used as substrates, hepatic formation of acid-soluble products was significantly increased in C14-S-acetic acid treated rats. Administration of C14-S-acetic acid resulted in increased enzyme activity and mRNA levels of hepatic mitochondrial carnitine palmitoyltransferase (CPT)-II. CPT-II activity correlated with both palmitoyl-CoA and palmitoyl-l-carnitine oxidation in rats treated with different chain-length 3-thia fatty acids. CPT-I activity and mRNA levels were, however, marginally affected. The hepatic CPT-II activity was mainly localized in the mitochondrial fraction, whereas the CPT-I activity was enriched in the mitochondrial, peroxisomal, and microsomal fractions. In C14-S-acetic acid-treated rats, the specific activity of peroxisomal and microsomal CPT-I increased, whereas the mitochondrial activity tended to decrease. C14-S-Acetyl-CoA inhibited CPT-I activity in vitro. The sensitivity of CPT-I to malonyl-CoA was unchanged, and the hepatic malonyl-CoA concentration increased after C14-S-acetic acid treatment. The mRNA levels of acetyl-CoA carboxylase increased. In hepatocytes cultured from palmitic acid- and C14-S-acetic acid-treated rats, the CPT-I inhibitor etomoxir inhibited the formation of acid-soluble products 91 and 21%, respectively. In contrast to 3-thia fatty acid treatment, eicosapentaenoic acid treatment and starvation increased the mitochondrial CPT-I activity and reduced its malonyl-CoA sensitivity. Palmitoyl-l-carnitine oxidation and CPT-II activity were, however, unchanged after either EPA treatment or starvation. The results from this study open the possibility that the rate control of mitochondrial β-oxidation under mitochondrion and peroxisome proliferation is distributed between an enzyme or enzymes of the pathway beyond the CPT-I site after 3-thia fatty acid treatment. It is suggested that fatty acids are partly oxidized in the peroxisomes before entering the mitochondria as acylcarnitines for further oxidation. 相似文献
216.
ABAQUS FE simulations of hydrogen diffusion in duplex stainless steel have been performed. Three models with different ferrite–austenite configurations have been applied and the hydrogen diffusion and the hydrogen coefficient have been evaluated as a function of austenite phase size and shape and the calculated diffusion coefficients compared to literature. Hydrogen concentration due to stress and plastic strain close to an embedded flaw has also been evaluated. An important observation is that the simulations show that when the austenite phases are saturated with hydrogen there is no large difference in the overall diffusion rate between the small and large phased models, i.e. no influence of tortuosity is observed. The work clearly demonstrates that both microstructure and flaws will influence the hydrogen diffusion and the hydrogen concentration and hence, must be taken into account when evaluating the susceptibility of hydrogen stress cracking in duplex stainless steels. 相似文献
217.
Taylor Donald M.; Simard Lise M.; Papineau Danielle 《Canadian Metallurgical Quarterly》1978,10(3):181
Examined the role of perceived cultural differences and patterns of language use regarding intergroup relations in Quebec. The participants were 90 francophone and anglophone executives who were involved in a 3-day program requiring intensive interaction and cooperation to complete their task requirements. A questionnaire administered at the end of the program focused on (a) participants' beliefs about francophone and anglophone differences in approach to and execution of the job, and (b) patterns of language use throughout the 3-day period. Most francophones believed that cultural differences do exist, and they respected the unique attributes of both groups. Most anglophones did not believe in the current existence of cultural differences and felt that the specific characteristics of the 2 groups had been blended over time. The English language was used more than would be predicted on the basis of the number of francophones and anglophones; however, there was greater language parity than has historically been reported. (French summary) (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
218.
Rizzi A Raddadi N Sorlini C Nordgrd L Nielsen KM Daffonchio D 《Critical reviews in food science and nutrition》2012,52(2):142-161
The fate of dietary DNA in the gastrointestinal tract (GIT) of animals has gained renewed interest after the commercial introduction of genetically modified organisms (GMO). Among the concerns regarding GM food, are the possible consequences of horizontal gene transfer (HGT) of recombinant dietary DNA to bacteria or animal cells. The exposure of the GIT to dietary DNA is related to the extent of food processing, food composition, and to the level of intake. Animal feeding studies have demonstrated that a minor amount of fragmented dietary DNA may resist the digestive process. Mammals have been shown to take up dietary DNA from the GIT, but stable integration and expression of internalized DNA has not been demonstrated. Despite the ability of several bacterial species to acquire external DNA by natural transformation, in vivo transfer of dietary DNA to bacteria in the intestine has not been detected in the few experimental studies conducted so far. However, major methodological limitations and knowledge gaps of the mechanistic aspects of HGT calls for methodological improvements and further studies to understand the fate of various types of dietary DNA in the GIT. 相似文献
219.
Helen E. Kvalem Helle K. Knutsen Cathrine Thomsen Margaretha Haugen Hein Stigum Anne Lise Brantsæter May Frøshaug Nina Lohmann Olaf Päpke Georg Becher Jan Alexander Helle M. Meltzer 《Molecular nutrition & food research》2009,53(11):1438-1451
Dietary patterns were related to intake and blood concentrations of polychlorinated dibenzo‐p‐dioxins and dibenzofurans (PCDD/PCDFs), dioxin‐like polychlorinated biphenyls (dl‐PCBs) and selected non‐dioxin‐like‐PCBs (ndl‐PCBs). Intake calculations were based on an extensive food frequency questionnaire and a congener‐specific database on concentrations in Norwegian foods. The study (2003) applied a two‐step inclusion strategy recruiting representative (n=73) and high consumers (n=111) of seafood and game. Estimated median intakes of sum PCDD/PCDFs and dl‐PCBs of the representative and high consumers were 0.78 and 1.25 pg toxic equivalents (TEQ)/kg bw/day, respectively. Estimated median intakes of ndl‐PCBs (sum chlorinated biphenyl (CB)‐28, 52, 101, 138, 153, 180) were 4.26 and 6.40 ng/kg bw/day. The median blood concentrations of PCDD/PCDFs/dl‐PCBs were 28.7 and 35.1 pg TEQ/g lipid, and ndl‐PCBs (sum of CB‐101, 138, 153 and 180) 252 and 299 ng/g lipid. The Spearman correlations between dietary intake and serum concentration were r=0.34 (p=0.017) for dl‐compounds and r=0.37 (p<0.001) for ndl‐PCBs. Oily fish was the major source of dl‐compounds and ndl‐PCBs in high and representative consumers. Four dietary patterns were identified by principal component analysis. Two were related to high intakes, one dominated by oily fish ((Ω‐3)), the other by fish liver and seagull eggs (“northern coastal”). Only the latter was closely associated with high blood concentrations of dioxins and PCBs. 相似文献
220.
The purpose of this cross-sectional study was to investigate confidentiality as a possible barrier to emotional support in a sample of 464 Norwegian nurses, rescue workers, police officers, chaplains, and undertakers. Informal discussions more than formal meetings were settings where emotional work experiences could be aired. The most important sources of emotional support were partners and colleagues. The need to maintain confidentiality was associated with lower utilization of personal support network. Confidentiality, the need to demonstrate emotional capability, and professional integrity were identified as barriers for seeking support. These barriers were present regardless of organizational strategies to support each other in formal and informal meetings. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献