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101.
Smith JT Wright SM Cross MA Monte L Kudelsky AV Saxén R Vakulovsky SM Timms DN 《Environmental science & technology》2004,38(3):850-857
Atmospheric nuclear weapons explosions and large-scale nuclear accidents may contaminate large areas of land with the long-lived radionuclides 137Cs and 90Sr. The mobility and bioavailability of these radionuclides in the environment is dependent primarily on soil characteristics and changes significantly over time after fallout (1-4). Radioisotope concentrations in different rivers and at different times after fallout vary over 2-3 orders of magnitude. Many previous studies have concentrated on the interactions of radiocesium and radiostrontium with various environmental components, but there are currently no operative models fortheirtransport over large spatial areas. We collected time-series measurements of 90Sr and 137Cs in 25 major European and Asian rivers and (using digital data sets with global coverage) determined characteristics of each of the rivers' catchments. This work has established, for the first time, a quantitative link between riverine transport of these radioisotopes and catchment and soil characteristics at a global scale. A generalized predictive model accounting for time changes in river concentrations and variation in catchment characteristics is developed. This can be used to predict the long-term riverine transport of these radiologically important radionuclides following any large-scale nuclear incident in North America, Europe, or (European and Asian) Russia. 相似文献
102.
Bedini Luigi Bramanti Mauro Denoth F. 《IEEE transactions on bio-medical engineering》1980,(11):623-630
In this paper the electromagnetic interaction between a resonator and a lossy dielectric body is examined by means of a simple model suitable for computer simulation; the body was assumed to have a revolution form and the resonator was electromagnetic coupled to the body by its inductive element constituted by a planar circular or spiral coil. On the basis of the model a computer program was derived which allows a simple numerical evaluation of the variation in the resonant frequency caused by the interaction mentioned above. 相似文献
103.
104.
Nassimbeni LR 《Accounts of chemical research》2003,36(8):631-637
The macro properties of crystalline inclusion compounds depend on their structures. Their thermal stabilities are a function of the strength and the directionality of the various nonbonded interactions occurring in the host-guest assembly. Their lattice energies, as measured by the method of atom-atom potentials, correlate with the thermodynamics of the guest-release reactions and the selectivity that a given host displays for a particular guest. The kinetics of solid-host:vapor-guest reactions and of guest exchange are important in our understanding of catalytic processes. Crystal engineering, in which materials of predetermined properties may be synthesized, is still at the empirical stage. 相似文献
105.
Falcieri E Burattini S Bortul R Luchetti F Tabellini G Tazzari PL Cappellini A Cocco L Martelli AM 《Microscopy research and technique》2003,62(3):192-200
Two distinct types of cell death have been described: apoptosis and necrosis. However, it is becoming increasingly clear that the differences between these two types are far less numerous than initially thought. Morphological analyses might provide important information to distinguish apoptotic from necrotic samples. We recently reported that in necrotic, but not apoptotic, HL-60 human myeloid leukaemia cells, the nuclear protein topoisomerase IIalpha concentrated in nucleoli. In order to ascertain whether or not this phenomenon was restricted to a peculiar cell type or could be detected also in cells of lymphoid lineage, we performed an investigation aimed at defining the localization of topoisomerase IIalpha in apoptotic and necrotic Jurkat human T lymphoblastoid cells. Immunofluorescence staining demonstrated that topoisomerase IIalpha was excluded from the condensed chromatin of apoptotic cells, whereas in necrotic cells it was localized in discrete nuclear dots. Immuno-electron microscopy analysis showed that topoisomerase IIalpha was undetectable in nucleoli of normal and apoptotic cells, whereas it was present in the nucleolus of necrotic cells irrespectively of the type of inducer used (ethanol, H(2)O(2), HgCl(2)). Taken together, our findings identify topoisomerase IIalpha as a potential morphological marker useful to discriminate between apoptotic and necrotic cells. 相似文献
106.
107.
De Luca S Ragone R Bracco C Digilio G Aloj L Tesauro D Saviano M Pedone C Morelli G 《Chembiochem : a European journal of chemical biology》2003,4(11):1176-1187
A cyclic CCK8 analogue, cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 (Dpr=L-2,3-diaminopropionic acid), has been designed on the basis of the NMR structure of the bimolecular complex between the N-terminal fragment of the CCK(A) receptor and its natural ligand CCK8. The conformational features of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 have been determined by NMR spectroscopy in aqueous solution and in water containing DPC-d(38) micelles (DPC=dodecylphosphocholine). The structure of the cyclic peptide in aqueous solution is found to be in a relaxed conformation, with the backbone and Dpr29 side chain atoms making a planar ring and the N-terminal tripeptide extending approximately along the plane of this ring. In DPC/water, the cyclic peptide adopts a "boat-shaped" conformation, which is more compact than that found in aqueous solution. The cyclic constraint between the Dpr29 side chain and the CCK8 carboxyl terminus (Lys34) introduces a restriction in the backbone conformational freedom. However, the interaction of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 with the micelles still plays an important role in the stabilisation of the bioactive conformation. A careful comparison of the NMR structure of the cyclic peptide in a DPC micelle aqueous solution with the structure of the rationally designed model underlines that the turn-like conformation in the Trp30-Met31 region is preserved, such that the Trp30 and Met31 side chains can adopt the proper spatial orientation to interact with the CCK(A) receptor. The binding properties of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 to the N-terminal receptor fragment have been investigated by fluorescence spectroscopy in a micellar environment. Estimates of the apparent dissociation constant, K(d), were in the range of 70-150 nM, with a mean value of 120+/-27 nM. Preliminary nuclear medicine studies on cell lines transfected with the CCK(A) receptor indicate that the sulfated-Tyr derivative of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 displaces the natural ligand with an IC(50) value of 15 microM. 相似文献
108.
Bassarello C Cimino P Bifulco G Boger DL Smith JA Chazin WJ Gomez-Paloma L 《Chembiochem : a European journal of chemical biology》2003,4(11):1188-1193
We report the NMR solution structure of (+)-CPI-indole (CPI, 1,2,8,8a-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one), an agent belonging to the CC-1065/duocarmycin family of antitumor compounds. This (+)-CPI-indole structure is covalently bound to d(G(1)ACTAATTGTC(11))-d(G(12)TCAATTAGTC(22)), a synthetic DNA duplex containing a high-affinity binding site. The three-dimensional structure has been determined by several cycles of restrained molecular dynamics calculations with a total of 563 NMR-derived constraints, both in vacuo and by using the generalized Born solvent continuum model. In-depth analysis of the structure of this ligand-DNA complex led to a detailed knowledge of the bound state conformation of the CPI-indole, the most simplified agent related to CC-1065 and duocarmycins, the parent members of a family of extremely potent antitumor compounds. Comparison of the CPI-indole bound conformation with those previously found for (+)-duocarmycin SA (DSA), its unnatural enantiomer (-)-DSA, and the demethoxylated analogue (+)-DSI in their DNA complexes provided additional evidence of the tight correlation between the catalytic effect exerted by DNA on the alkylation reaction and the extent of angular twist between the two planar heteroaromatic subunits of these agents. Additionally, comparison of the structural features of the DNA-bound state of a "naked" ligand, such as CPI-indole, with those of various other duocarmycin agents provided useful information for the interpretation of the observed effects on chemical reactivity of the different substitution patterns at the hemispheres of these types of complex. 相似文献
109.
Marino F. Distante A. Pier Luigi Mazzeo Stella E. 《IEEE transactions on systems, man and cybernetics. Part C, Applications and reviews》2007,37(3):418-428
Rail inspection is a very important task in railway maintenance, and it is periodically needed for preventing dangerous situations. Inspection is operated manually by trained human operator walking along the track searching for visual anomalies. This monitoring is unacceptable for slowness and lack of objectivity, as the results are related to the ability of the observer to recognize critical situations. The correspondence presents a patent-pending real-time Visual Inspection System for Railway (VISyR) maintenance, and describes how presence/absence of the fastening bolts that fix the rails to the sleepers is automatically detected. VISyR acquires images from a digital line-scan camera. Data are simultaneously preprocessed according to two discrete wavelet transforms, and then provided to two multilayer perceptron neural classifiers (MLPNCs). The "cross validation" of these MLPNCs avoids (practically-at-all) false positives, and reveals the presence/absence of the fastening bolts with an accuracy of 99.6% in detecting visible bolts and of 95% in detecting missing bolts. A field-programmable gate array-based architecture performs these tasks in 8.09 mus, allowing an on-the-fly analysis of a video sequence acquired at 200 km/h 相似文献
110.