Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near-Infrared BODIPY Dye

Delving deeper is possible in whole-body in vivo imaging using a super-bright membrane-targeting BODIPY dye ( BD ). The dye was used to monitor homing of ex vivo fluorescently labelled neutrophils to an injured liver of dark-pigmented C57BL/6 mice. In vivo imaging system (IVIS) data conclusively showed an enhanced signal intensity and a higher signal-to-noise ratio in mice receiving neutrophils labelled with the BD dye relative to those labelled with a gold standard dye at 2 h post in vivo administration of fluorescently labelled cells. Fluorescence-activated cell sorting (FACS) confirmed that BD is nontoxic, and an exceptional cell labelling dye that opens up precision deep-organ in vivo imaging of inflammation in mice routinely used for biomedical research. The origin of enhanced performance is identified with the molecular structure and the distinct localisation of the dye within cells that enable remarkable changes in its optical parameters.     

Synthesis and characterization of cadmium(II)-imprinted poly(1-allyl-2-thiourea-co-ethylene glycol dimethacrylate) particles for selective separation

The synthesis and characterization of cadmium(II)-imprinted poly(1-allyl-2-thiourea-co-ethylene glycol dimethacrylate) particles are presented. Out of four functional monomers viz. allylurea, 1-vinylimidazole, acrylamide, and 1-allyl-2-thiourea, the last one was selected to produce a novel and selective separation material towards cadmium(II) ions. The energy dispersive X-ray spectroscopy confirmed the presence of monomer residues in the polymer matrix. The optimization of stoichiometry revealed that the highest binding capacity (3.79 ± 0.12 µg/g) and selectivity (imprinting factor of 13.68) were achieved when ion to monomer ratio was equal to 1:1. The structure, morphology and selectivity of imprinted polymer were examined. The imprinted particles possess regular, spherical shape and their surface is highly extended (10.31 ± 0.14 m²/g). The selectivity study towards ions which are present in the real sample showed highest uptake of cadmium(II) ions when compared to lead(II), cobalt(II) or nickel(II) ions with selectivity factors between 2.1 and 2.4.     

Impact of functional monomers,cross-linkers and porogens on morphology and recognition properties of 2-(3,4-dimethoxyphenyl)ethylamine imprinted polymers

The main objective of this paper was to examined the impact of synthetic reagents on morphology and recognition properties of 2-(3,4-dimethoxyphenyl)ethylamine imprinted polymers. The effect of nine different functional monomers, five porogens and four cross-linkers on the binding capacity of particles was analyzed. The results revealed that the highest imprinting factor (1.81) showed the polymer obtained from methacrylic acid and ethylene glycol dimethacrylate in toluene. The binding capacities of imprinted (MIP1) and non-imprinted (NIP1) materials were 135.3 ± 9.8 and 74.8 ± 7.8 μmol g^? 1, respectively. The specific surface areas were 55.05 ± 3.89 for MIP1 and 38.72 ± 2.40 m² g^? 1 for NIP1. The SEM analysis confirmed that the surface of MIP1 is rougher and denser than NIP1. Structural analysis supported by ¹³C CP/MAS NMR spectra was also performed. The binding abilities of homoveratrylamine and eight structurally related compounds to MIP1 showed that strong interactions between carboxylic group in the polymer and amine group in the analyte together with its molecular volume govern the recognition mechanism.     

基于相似日和IGA-BP的光伏发电功率预测方法研究

准确预测光伏发电功率有利于并网后电网调度管理,现阶段光伏发电功率预测存在精度较低和对不同天气类型的适应性弱的问题。探索了一种相似日与免疫遗传神经网络（IGA-BP）结合的预测方法：基于天气类型、温度及风速,结合灰色关联度和余弦相似度指标构建气象相似日判别模型;以相似日气象特征向量为输入,建立IGA-BP功率预测模型。利用实测数据对比分析所提IGA-BP模型与GA-BP、BP模型的预测精度,结果为：在不同天气类型下IGA-BP模型具有较高精度,其RMSE平均值为14.142%,TIC平均值为0.017 58,均优于其他对比模型。表明IGA-BP模型能够提高功率预测精度,且具有较高的适应性。     

三溴苯基马来酰亚胺的合成与应用

介绍了２,４,６－三溴苯基马来酰亚胺（ＴＢＰＭＩ）的合成方法和应用。     

汽车检具检测分析报告自动生成软件开发

开发了汽车检具检测分析报告自动生成软件,能根据测量仪器提供的检测数据自动生成检具检测分析报告。软件以Visual Studio.Net为开发工具,基于Windows系统进行人机交互界面的设计、检测数据的录入与校验,以及检测示意图的抓取,实现了图文并茂的检具检测分析报告的自动生成,大大提高了检测工作效率,降低了报告的差错率。     

基于深度学习的绝缘子缺失检测方法研究

绝缘子缺陷严重影响输电线路安全,航拍图像绝缘子缺失的有效识别是无人机线路巡检。提出一种轻量级网络的绝缘子缺失检测模型,使用轻量级网络MobileNetV3替换YOLOv4模型的CSPDarknet53网络。以分割性能和计算速度为判据,综合分析比较了YOLOv4模型和使用轻量型网络对其主干网络替换后的模型在绝缘子缺失检测上的性能,实验结果表明：筛选的YOLOv4-MobileNetV3轻量级网络绝缘子缺失检测模型能够准确定位图像中单、多目标绝缘子;改进后YOLOv4-MobileNetV3检测模型比原模型的体积减少了78%,FPS提升了4.85 f/s,而mAP仅降低0.6%。提出的绝缘子缺失检测方法能够满足无人机电力线路巡检的需求。     

果胶酶对百香果醋澄清作用的研究

以果胶酶作为澄清剂对百香果醋进行澄清处理,研究了酶用量、酶解温度和时间对澄清效果的影响.根据果胶酶对百香果醋澄清的单因素试验结果,采用正交试验对果胶酶用量、酶解温度和酶解时间等工艺参数进行优化,确定了适宜的反应条件为:果胶酶用量120mg/kg、温度45℃、反应时间150min.利用果胶酶澄清百香果醋能较好地避免二次混浊现象.     

Piper species protect cardiac,hepatic and renal antioxidant status of atherogenic diet fed hamsters

Pre-clinical and clinical studies points to the use of antioxidants as an effective measure to reduce the progression of oxidative stress related disorders. The present study evaluate the effect of three Piper species (Piper guineense, Piper nigrum and Piper umbellatum) for the protection of cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Hamsters were classified into eight groups: a normal control, atherogenic control and six other experimental groups (fed atherogenic diet supplemented with different doses of P. nigrum, P. guineense and P. umbellatum (1 and 0.25 g/kg) for 12 weeks. At the end of the feeding period the heart, liver and kidney from each group were analyzed for lipid profile and antioxidant enzymes activities. Atherogenic diet induced a significant (P < 0.001) increase in the lipid profile across the board and equally significantly altered the antioxidant enzyme activities. Supplementation with Piper species significantly inhibited the alteration effect of atherogenic diet on the lipid profile and antioxidant enzymes activities. The Piper extracts may possess an antioxidant protective role against atherogenic diet induced oxidative stress in cardiac, hepatic and renal tissues.     

A framework for half-time internship training in psychology.

In the past 50 years, psychology has so heavily emphasized the full-time internship as the preeminent training model that it has often overlooked the benefits of half-time internships for educators, students, the profession, and the populations that psychologists serve. This article makes a case for the nearly forgotten half-time predoctoral internship. The history and context of the half-time internship, culminating in a recent national conference, is presented. The benefits to students, doctoral programs, and the community are described, as well as obstacles and solutions for their implementation. Implications for developing more half-time internships for psychology stakeholders are also discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)