超声波探伤在铝合金中厚板检测中的应用

文章介绍了铝合金中厚板内部的常见缺陷,比较了超声波探伤铝合金中厚板的常用方法,展望了铝板超声波探伤未来的发展。     

子母车系统效率分析与验证

在子母车系统中,研究一台母车配合两台子车在同层进行复合作业的效率问题,提高系统作业效率计算的准确性,优化系统整体布局和物流设备的选择。首先分析一台母车配合两台子车在同层的循环复合作业过程;然后结合子母车的运动特性得到其作业效率计算模型;最后采用MATLAB工具计算效率模型分别在随机组合作业对和FEM9.851标准作业对的作业效率,通过对比验证,两种循环作业的效率绝对偏差符合工程实际。在工程实际中可以参照FEM9.851标准作业对代替随机组合作业对进行子母车系统的效率计算。     

液压支架让缩性能试验特性分析与探讨

分析研究国家标准中液压支架让缩性能试验的技术要求,设计开发让缩性能试验系统,以双伸缩立柱液压支架为研究对象进行让缩性能试验分析与研究,为让缩性能试验的开展提供了试验条件,为液压支架国标的实施提供基础。     

PET的紫外老化性能及机理研究

采用力学、紫外-可见光分析和热失质等测试手段研究了PET改性料的紫外老化性能及老化机理。结果表明:复合助剂的加入能显著提升体系的力学性能保持率,进而提升其紫外老化寿命,提升的幅度随复合助剂中耐紫外剂含量的增加而显著增加。DSC分析表明,随着复合助剂的引入和老化的进行,改性料结晶度增加。文中进一步讨论了PET改性料的紫外老化机理。紫外-可见光分析表明,紫外老化能产生醌类和双醌类物质,进而提升PET改性料的紫外吸收度。     

Bioinformatic characterization of the extracellular lipases from Kluyveromyces marxianus

Lipases are hydrolytic enzymes that break the ester bonds of triglycerides, generating free fatty acids and glycerol. Extracellular lipase activity has been reported for the nonconventional yeast Kluyveromyces marxianus, grown in olive oil as a substrate, and the presence of at least eight putative lipases has been detected in its genome. However, to date, there is no experimental evidence on the physiological role of the putative lipases nor their structural and catalytic properties. In this study, a bioinformatic analysis of the genes of the putative lipases from K. marxianus L-2029 was performed, particularly identifying and characterizing the extracellular expected enzymes, due to their biotechnological relevance. The amino acid sequence of 10 putative lipases, obtained by in silico translation, ranged between 389 and 773 amino acids. Two of the analysed putative proteins showed a signal peptide, 25 and 33 amino acids long for KmYJR107Wp and KmLIP3p, and a molecular weight of 44.53 and 58.23 kDa, respectively. The amino acid alignment of KmLIP3p and KmYJR107Wp with the crystallized lipases from a patatin and the YlLip2 lipase from Yarrowia lipolytica, respectively, revealed the presence of the hydrolase characteristic motifs. From the 3D models of putative extracellular K. marxianus L-2029 lipases, the conserved pentapeptide of each was determined, being GTSMG for KmLIP3p and GHSLG for KmYJR107Wp; besides, the genes of these two enzymes (LIP3 and YJR107W) are apparently regulated by oleate response elements. The phylogenetic analysis of all K. marxianus lipases revealed evolutionary affinities with lipases from abH15.03, abH23.01, and abH23.02 families.     

K4,4,p的点可区别的IE-全染色(p≥1008)

该文利用色集事先分配法、构造染色法、反证法探讨了完全三部图K_4,4,p (p≥1008)的点可区别IE-全染色问题，确定了K_4,4,p (p≥1008)的点可区别IE-全染色数。     

Microenvironment and related genes predict outcomes of patients with cervical cancer: evidence from TCGA and bioinformatic analysis

Cervical cancer (CESC) is one of the most common cancers and affects the female genital tract. Consistent HPV infection status has been determined to be a vital cause of tumorigenesis. HPV infection may induce changes to the immune system and limit the host’s immune response. Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients. Using 304 relevant samples from TCGA, we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC. Functional enrichment analysis, pathway enrichment analysis, and PPI network construction were performed to explore the differentially expressed genes (DEGs). The analysis identified 425 DEGs, which included 295 up-regulated genes and 130 down-regulated genes. We established that upregulation of CCL5 was correlated with significantly better survival, meaning that CCL5 expression could serve as a novel prognostic biomarker for CESC patients. We further focused on CCL5 as a hub gene in CESC, as it had significant correlations with increased numbers of several types of immune cells. Cell-type fractions of M1 macrophages were significantly higher in the high-immune-scores group, which was associated with better overall survival. Finally, we concluded that CCL5 is a promising prognostic biomarker for CESC, as well as a novel chemotherapeutic target.     

网络安全等级保护测评中测评结论的度量方法优化

文章分析了网络安全等级保护2.0时期国家标准的新变化对等级测评结论可能产生的影响,并用实际案例和数据论述了以往描述的基于测评指标和基于测评对象的定量分析方法存在的局限性。根据网络安全等级保护国家标准结构和内容的新特点,结合新的等级测评结论表述方法,文章提出了调整和优化定量计算产生等级测评结论的思路,给出了缺陷扣分的原理和缺陷扣分的定量计算方法,并比较了各种定量计算方法在计算结果上的差异,提出了适合新标准的测评结论定量计算公式。