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81.
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83.
探讨信号转导和转录激活子5(STAT5)信号转导途径在受辐射KG-1细胞中对细胞周期的调控作用。通过转染STAT5基因的显性负突变体(DN-STAT5)阻断JAK/STAT的信号传递后,瞬间转染cyclinD1基因及cyclinB1基因,观察cyclinD1蛋白及cyclinB1蛋白对受辐射细胞周期阻滞的影响作用。转染DN-STSAT5基因的受辐射KG-1细胞即使用粒-巨噬细胞集落刺激因子(GM-CSF)刺激亦不能跳出G1期阻滞;瞬间转染cyclinD1基因及cyclinB1基因分别能促进受辐射细胞跳出G1期和G2期阻滞。GM-CS所激活的JAK/STAT信号转导途径通过促进周期蛋白cyclinD1及cyclinB1的表达而对受辐射细胞周期进行调控。 相似文献
84.
Xi Li Shanzhi Chen Dan Chen Hong Ji Victor C. M. Leung 《International Journal of Communication Systems》2013,26(4):530-548
With the introduction of low‐powered pico/femto‐base stations and relay nodes into the macro‐cell, recent heterogeneous networks provide an attractive approach for future wireless communication. Although it may achieve better coverage and higher capacity, several problems remain unsolved before practical deployment. For example, how to select the proper cell from neighbor low‐powered cells and then occupy the radio resource without interference on macro‐users is both important and challenging, especially for rigorous multimedia applications. The traditional cell access algorithms and quality‐control parameters such as delay or throughput no longer suit well in this complex environment. An effective approach should be pursued. In this paper, we investigate this interesting cell association problem and propose a complete green resolution on the basis of thorough discussions about the multimedia transmission under these concerns. Cognitive radio is introduced to share spectrum between macro‐cell and low‐powered cells while securing the transmission of authorized macro‐users. We also bring forth the concept of ‘interference balance’ to better manage the overall interference and energy consumption in the network. Restless bandit model is formulated on the basis of channel state, data rate, interference control, and the carefully chosen intra‐refreshing rate for multimedia traffic. Then the cell association scheme is designed to be efficient and practical because of the simple index property of our model output. Simulation results have proven the performance of our proposed resolution compared with existing algorithms on interference constraint, multimedia distortion, and overall network energy consumption balance. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
85.
工艺参数对马氏体不锈钢激光冲击区表面轮廓的影响 总被引:1,自引:0,他引:1
激光功率密度和搭接率对马氏体不锈钢的激光冲击区的表面轮廓有较大影响.激光功率密度从3.79 GW/cm2到7.25 GW/cm2,冲击区塑性变形程度随功率密度增大而增大,当激光功率密度为6.09 GW/cm2时,冲击区塑性变形程度适中,其残余应力平均值达-569.1 MPa.搭接率试验结果表明,搭接率为33%时,可获得较大面积无挤出的激光冲击区,无挤出区域的塑性均匀,变形深度波动幅度在2μm以内,而且此搭接率下冲击区挤出面积较小,分布具有规律,便于再次冲击以降低冲击区的表面波纹度. 相似文献
86.
王丹 《南京工业职业技术学院学报》2007,7(4):15-17
针对红外图像边缘模糊和非均匀性噪声强的特点,提出了一种基于加权的自适应红外图像边缘增强方法。该方法不仅增强红外图像边缘,而且改善了传统边缘增强算法对图像噪声放大的缺点,避免了对强边缘的过渡增强导致图像出现过增强现象,改善了图像质量。实验结果表明,该方法具有良好的前景和实用价值。 相似文献
87.
Xuejing Zhu Dan Gao Vittorio Albertazzi Jianyong Zhong Li-Jun Ma Liping Du Yu Shyr Valentina Kon Hai-Chun Yang Agnes B. Fogo 《International journal of molecular sciences》2022,23(11)
We previously found that short-term treatment (week 8 to 12 after injury) with high-dose angiotensin receptor blocker (ARB) induced the regression of existing glomerulosclerosis in 5/6 nephrectomy rats. We therefore assessed the effects of long-term intervention with ARB vs. nonspecific antihypertensives in this study. Adult rats underwent 5/6 nephrectomy and renal biopsy 8 weeks later. The rats were then divided into three groups with equivalent renal function and glomerular sclerosis and treated with high-dose losartan (ARB), nonspecific antihypertensive triple-therapy (TRX), or left untreated (Control) until week 30. We found that blood pressure, serum creatinine levels, and glomerulosclerosis were lower at sacrifice in ARB and TRX vs. Control. Only ARB reduced proteinuria and maintained the density of WT-1-positive podocytes. Glomerular tufts showed more double-positive cells for CD44, a marker of activated parietal epithelial cells, and synaptopodin after ARB vs. TRX or Control. ARB treatment reduced aldosterone levels. ARB-treated rats had significantly improved survival when compared with TRX or Control. We conclude that both long-term ARB and triple-therapy ameliorate progression, but do not sustain the regression of glomerulosclerosis. ARB resulted in the superior preservation of podocyte integrity and decreased proteinuria and aldosterone, linked to increased survival in the uremic environment. 相似文献
88.
天丝/竹浆纤维/牛奶纤维/真丝混色纺细特转杯纱的研制 总被引:3,自引:2,他引:1
介绍了天丝、竹浆纤维、牛奶蛋白纤维、真丝的规格特性及其混色转杯纱的主要特性,探讨了混色纺细特转杯纱生产中的主要工艺参数、技术措施和注意事项。 相似文献
89.
Yongjie Liu Dan Li Shengquan Zhang Liping Zhang Jie Gong Yanhong Li Jiamin Chen Fengting Zhang Xiangzheng Liao Zhaobo Chen Yongbo Wang Binshuang Pang Jinxiu Ma Xianchao Chen Jiangang Gao Changping Zhao Shiqing Gao 《International journal of molecular sciences》2022,23(15)
Temperature-sensitive genic male sterile (TGMS) line Beijing Sterility 366 (BS366) has been utilized in hybrid breeding for a long time, but the molecular mechanism underlying male sterility remains unclear. Expression arrays, small RNA, and degradome sequencing were used in this study to explore the potential role of miRNA in the cold-induced male sterility of BS366. Microspore observation showed defective cell plates in dyads and tetrads and shrunken microspores at the vacuolated stage. Differential regulation of Golgi vesicle transport, phragmoplast formation, sporopollenin biosynthesis, pollen exine formation, and lipid metabolism were observed between cold and control conditions. Pollen development was significantly represented in the 352 antagonistic miRNA-target pairs in the integrated analysis of miRNA and mRNA profiles. The specific cleavage of ARF17 and TIR1 by miR160 and miR393 were found in the cold-treated BS366 degradome, respectively. Thus, the cold-mediated miRNAs impaired cell plate formation through repression of Golgi vesicle transport and phragmoplast formation. The repressed expression of ARF17 and TIR1 impaired pollen exine formation. The results of this study will contribute to our understanding of the roles of miRNAs in male sterility in wheat. 相似文献
90.
采用射频磁控溅射技术和复合靶材方法制备了掺Mn,掺Co和Co、Mn共掺的SiC薄膜,经高温退火后进行了光致发光(PL)谱的测量,还用X射线衍射(XRD),傅立叶变换红外光谱(FTIR),扫描电镜(SEM)等表征手段分析了薄膜的相结构和表面形貌,并与光致发光的结果进行了对比研究.结果表明,掺Mn、Co使SiC晶格发生畸变,X射线衍射峰强度下降,Si-C吸收谱变宽,Si-C键振动减弱,Si-O基团的振动增强.样品在室温条件下均呈现出强的紫光发射特性,发光峰均位于414nm(3.0eV),认为414nm处的光致发光峰对应于光激发产生的电子从导带底到Si空位浅受主能级之间的辐射跃迁,其强度取决于Si空位的浓度. 相似文献