The design of experiments when there are errors in all the variables

The Error-in-Variables Model (EVM) applies to a large class of problems in parameter estimation in which there is error in all the variables. This property makes it of more general applicability than the widely used technique of ordinary Least Squares. While there is a voluminous literature on EVM there is nothing on a general method for designing experiments when EVM applies. In this paper we present an extension of the concept of D-optimality to provide such a general method. It is illustrated by applying it to the estimation of copolymer reactivity ratios and to fitting an ellipse.     

Complex frequency technique for linear and second harmonic optical properties of metallic surfaces

We describe a complex frequency technique for evaluating the linear and quadratic dielectric responses of metal surfaces, illustrated by application to the surface of jellium. The electric susceptibilities are shorter-range functions of the spatial coordinates at complex frequency, whereas their general behaviour is complicated, long-range and highly oscillatory at real frequency. As a result the linear and the second harmonic electric charges induced by an optical perturbation are then numerically easier to calculate at complex frequency. As the functions which characterize the optical behaviour of the metal surface are analytic in the upper complex frequency half-plane, the dielectric response at real frequency can be deduced by analytic continuation from the results at complex frequency. We illustrate and discuss this approach, which should be useful for studying more realistic models of a surface in which the crystal potential is included, and where a direct calculation of the dielectric response is difficult to obtain at real frequency.     

MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies

The aim of the study was to test the hypothesis that magnetic resonance (MR) imaging-guided and -monitored noninvasive ultrasonic surgery can be performed in highly perfused tissues from outside the body. A simulation study was performed to evaluate the optimal sonication parameters. An MR-compatible positioning device was then used to manipulate a focused ultrasound transducer in an MR imager, which was used to sonicate kidneys of five rabbits at various power levels and different durations. Temperature elevation during sonication was monitored with a T1-weighted spoiled gradient-echo sequence. The simulation study demonstrated that a sharply focused transducer and relatively short sonication times (30 seconds or less) are necessary to prevent damage to the overlying skin and muscle tissue, which have a much lower blood perfusion rate than kidney. The experiments showed that the imaging sequence was sensitive enough to show temperature elevation during sonication, thereby indicating the location of the beam focus. Histologic evaluations showed that kidney necrosis could be consistently induced without damage to overlying skin and muscle. The study demonstrated that highly perfused tissues such as the renal cortex can be coagulated from outside the body with focused ultrasound and that MR imaging can be used to guide and monitor this surgery.     

Theory and implementation of NDT data fusion

Scientific measurements from single or multiple sensors are usually incomplete and uncertain. A process making use of the concept of data fusion has been developed to try to encompass this problem by combining information from multiple sensors. The objective to synergistic use of information from multiple sources is to reduce uncertainty and increase the confidence level of a measurand. The implementation of data fusion to the field of NDT is relatively new. This paper summarizes the achievements of current research on data fusion applied to NDT. A theoretical data fusion strategy is described and experimental results generated from weld inspection are presented.     

Controversy and consensus regarding the use of cognitive ability testing in organizations.

Seven hundred three members of the Society for Industrial and Organizational Psychology indicated agreement or disagreement with 49 propositions regarding cognitive ability tests in organizations. There was consensus that cognitive ability tests are valid and fair, that they provide good but incomplete measures, that different abilities are necessary for different jobs, and that diversity is valuable. Items dealing with the unique status of cognitive ability were most likely to generate polarized opinions. A 2-factor model, classifying items as those reflecting societal concerns over the consequences of ability testing and those reflecting an emphasis on the unique status of "g," fit the data well, and these factors proved especially important for predicting responses to the more controversial items. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

钢的连铸用保护渣的表征

在钢的连铸过程中,结晶器保护渣的性质强烈地影响着铸造的行为、钢的质量、以及连铸工艺的环境.本研究采用高温显微技术来研究保护渣的熔化行为,采用液滴测试方法来测定保护渣的熔化速率.结果表明:自由碳是控制保护渣熔化行为的主要因素.熔化速率随碳的反应能力的增加而增加,随着碳含量的减少而增加.     

Markov decision processes with delays and asynchronous cost collection

Markov decision processes (MDPs) may involve three types of delays. First, state information, rather than being available instantaneously, may arrive with a delay (observation delay). Second, an action may take effect at a later decision stage rather than immediately (action delay). Third, the cost induced by an action may be collected after a number of stages (cost delay). We de rive two results, one for constant and one for random delays, for reducing an MDP with delays to an MDP without delays, which differs only in the size of the state space. The results are based on the intuition that costs may be collected asynchronously, i.e., at a stage other than the one in which they are induced, as long as they are discounted properly.     

Ornithine decarboxylase transformation of NIH/3T3 cells is mediated by altered epidermal growth factor receptor activity

Ornithine decarboxylase (ODC) has been shown to be oncogenic in transfected NIH/3T3 cells overexpressing the enzyme from a heterologous promoter. These cells, designated as NODC-2 cells, acquire proliferative properties associated with tumorigenic transformation such as loss of contact inhibition, decreased population doubling time, anchorage-independent growth, and tumor production in nude mice. At least one of these parameters, loss of contact inhibition, remains dependent on elevated ODC levels. We have used these cells to investigate the molecular mechanisms by which ODC overexpression drives cell transformation and to examine the involvement of other proto-oncogene products in this process. An interaction between ODC overexpression and the epidermal growth factor receptor (EGF-R) was suggested initially by the elevation of both basal (300%) and ligand-induced (457%) EGF-R tyrosine kinase activities in NODC-2 cells compared to similarly treated control NLK cells. Disruption of EGF-R mediated signal transduction in NODC-2 cells both by treatment with tyrphostin-25 or by transfection with a vector expressing a dominant negative EGF-R mutant resulted in reacquisition of contact-inhibited growth and suppression of anchorage-independent, clonogenic growth in soft agar. We conclude that ODC-induced transformation of NIH/3T3 cells is mediated, at least partly, by alterations in EGF-R signal transduction activity.