Multi-scale modelling of manufacturing systems using ontologies and delta-lenses

The adoption of digital technologies in manufacturing enables intelligent dynamic control approaches, at the cost of increased design complexity. In this paper, ontologies and delta-lenses are exploited to enable multi-scale models of a manufacturing system to map digital models at different scales and let data flow according to the level of fidelity. A workflow is designed to assess the capability of models with a lower level of details to approximate the behaviour of the original system, through the application of a hybrid delta-lens. The approach is illustrated with a user case and applied to an industrial case, aiming at deciding the positions of sensors in an assembly line.     

The Politics of Place: citing and re-siting the Palazzo Littorio,Mussolini's New Fascist Party Headquarters in Rome

In 1934 and in 1937, two rounds of a major architectural competition were held for the Palazzo Littorio, the new Fascist Party Headquarters in Rome to be built in the heart of the ancient city and measuring its architectural worth against the Colosseum itself. Once the second round was announced, foreign and domestic policy shifted towards a more repressive climate and Italy had become an Empire. The processes behind the competitions represent the relationship between architecture and consent, the establishment and development of a ‘Fascist’ style, the Monumentalism versus Rationalism debate and increasing Party influence over artistic expression.     

Model-based scale-up of vacuum contact drying of pharmaceutical compounds

An integrated methodology for the scale-up of vacuum contact drying with intermittent agitation is described in this work. The methodology combines a mathematical model of vacuum contact drying, based on differential transient heat and energy balances, and a small-scale experimental apparatus for model validation and parameter estimation. The validated model was used for the estimation of drying times of six different pharmaceutical compounds at the pilot and manufacturing scale over a range of drying conditions – pressure 15–200 mbar, temperature 45–70 °C, solvents: acetone, water, methanol, n-propanol, and isopropyl acetate. The mean difference between predicted and actual drying times for the six compounds was less than 9%, which is considered a significant improvement over current semi-empirical approaches to vacuum contact drying scale-up.     

Post‐Deposition Activation of Latent Hydrogen‐Bonding: A New Paradigm for Enhancing the Performances of Bulk Heterojunction Solar Cells

Small conjugated molecules (SM) are gaining momentum as an alternative to semiconducting polymers for the production of solution‐processed bulk heterojunction (BHJ) solar cells. The major issue with SM‐BHJs is the low carrier mobility due to the scarce control on the phase‐segregation process and consequent lack of preferential percolative pathways for electrons and holes to the extraction electrodes. Here, a new paradigm for fine tuning the phase‐segregation in SM‐BHJs, based on the post‐deposition exploitation of latent hydrogen bonding in binary mixtures of PCBM with suitably functionalized electron donor molecules, is demonstrated. The strategy consist in the chemical protection of the H‐bond forming sites of the donor species with a thermo‐labile functionality whose controlled thermal cleavage leads to the formation of stable, crystalline, phase‐separated molecular aggregates. This approach allows the fine tuning of the nanoscale film connectivity and thereby to simultaneously optimize the generation of geminate carriers at the donor–acceptor interfaces and the extraction of free charges via ordered phase‐separated domains. As a result, the PV efficiency undergoes an over twenty‐fold increase with respect to control devices. This strategy, demonstrated here with mixtures of diketopyrrolopyrrole derivatives with PCBM can be extended to other molecular systems for achieving highly efficient SM‐BHJ solar cells.     

Chemical Diversity and Defence Metabolism: How Plants Cope with Pathogens and Ozone Pollution

Chemical defences represent a main trait of the plant innate immune system. Besides regulating the relationship between plants and their ecosystems, phytochemicals are involved both in resistance against pathogens and in tolerance towards abiotic stresses, such as atmospheric pollution. Plant defence metabolites arise from the main secondary metabolic routes, the phenylpropanoid, the isoprenoid and the alkaloid pathways. In plants, antibiotic compounds can be both preformed (phytoanticipins) and inducible (phytoalexins), the former including saponins, cyanogenic glycosides and glucosinolates. Chronic exposure to tropospheric ozone (O₃) stimulates the carbon fluxes from the primary to the secondary metabolic pathways to a great extent, inducing a shift of the available resources in favour of the synthesis of secondary products. In some cases, the plant defence responses against pathogens and environmental pollutants may overlap, leading to the unspecific synthesis of similar molecules, such as phenylpropanoids. Exposure to ozone can also modify the pattern of biogenic volatile organic compounds (BVOC), emitted from plant in response to herbivore feeding, thus altering the tritrophic interaction among plant, phytophagy and their natural enemies. Finally, the synthesis of ethylene and polyamines can be regulated by ozone at level of S-adenosylmethionine (SAM), the biosynthetic precursor of both classes of hormones, which can, therefore, mutually inhibit their own biosynthesis with consequence on plant phenotype.     

Identification and characterization of an extracellular protease activity produced by the marine Vibrio sp. 60

Since nitric oxide (NO) has been widely accepted as a novel neuromodulator, which activates soluble forms of guanylate cyclase to increase in guanosine 3':5'-cyclic monophosphate (cyclic GMP) levels, the effect of water-soluble substance in cigarette smoke on cyclic GMP levels were investigated using nerve terminals prepared from rat cerebral cortex. Although the smoke-substance itself failed to affect cyclic GMP levels in the synaptosomes, the smoke-substance significantly inhibited the increases in cyclic GMP levels induced by NO donors. The blocking effect of the smoke-substance was inhibited by concomitant incubation with superoxide dismutase, but not with mannitol. In addition, the effect of smoke-substance was mimicked by products of the xanthine/xanthine oxidase system, but not by nicotine. The effect of smoke-substance was preserved at least 7 days after they were stored at room temperature. Therefore, these results suggest that the smoke-substance may possess long half-lives to produce the radicals which inactivate NO, and to inhibit the increase in cyclic GMP levels in nerve terminals. The interference with NO may explain the part of mechanism in effects of cigarette smoke on neuronal functions.     

Fluid-Dynamic Study of Deformable Materials in Spouted-Bed Dryer

The present work is concerned with a fluid-dynamic study in spouted beds using deformable dice pieces of red guava. Data are presented on structural variations of the bed due to changes of regime during drying. Variation of physical properties (size and density) results from the volumetric shrinkage of these materials. Alterations in the fluid-dynamic stability of the spouted bed were correlated with Archimedes number. Along the process, the transition from fixed bed to fluidization can be observed, followed by stable spout and slugging. Mapping of the different regimes as a function of the moisture content is also presented.     

Evolution of a maturity model – critical evaluation and lessons learned

A system documentation process maturity model and assessment procedure were developed and used to assess 78 projects at 28 different companies over a five year period. During this time the original version evolved into second and third versions based on feedback from industry and the experience gained from the assessments. The changes to the model, maturity levels, key practices, scoring scheme and assessment report, and the reasons behind these changes are analyzed in this paper. The biggest lesson learned is that the key practices' degree of satisfaction and not the maturity levels drive the assessment and provide the key information needed for process improvement.