隔离病房回风高效过滤器滤菌效率的实验研究

介绍了国外各类高效过滤器的滤菌效率。在安装有高效过滤器的隔离病房回风口进行了发菌实验,计算了B类和C类回风高效过滤器的滤菌效率,证明了当隔离病房回风口安装高效过滤器时,可使用部分循环风。     

高温相变蓄热电暖器散热功率调节性能试验研究

对笔者研制的高温相变蓄热电暖器风道、散热肋片的强化散热性能及风门对散热量的调节特性进行了试验研究,结果表明风道、散热肋片可显著强化散热,不同风门开度下散热功率差别明显。     

隔离病房隔离效果的研究(1)

从理论上分析总结了影响隔离效果的因素:压差、门的开关、人的进出、温差及缓冲室的设置。建立了实验用单床隔离病房和双床隔离病房,对三种送排风口方案及缓冲室的隔离效果进行了实验研究。指出压差不能抵消其他因素的影响;提出主流区和定向气流是保护医护人员的首要措施;证明床侧和床尾双送风口效果最好;提出用缓冲室稀释、自净、过滤在动态条件下外泄的污染物是最重要的动态隔离措施。     

Immobilization of Lathyrus cicera Amine Oxidase on Magnetic Microparticles for Biocatalytic Applications

Amine oxidases are enzymes belonging to the class of oxidoreductases that are widespread, from bacteria to humans. The amine oxidase from Lathyrus cicera has recently appeared in the landscape of biocatalysis, showing good potential in the green synthesis of aldehydes. This enzyme catalyzes the oxidative deamination of a wide range of primary amines into the corresponding aldehydes but its use as a biocatalyst is challenging due to the possible inactivation that might occur at high product concentrations. Here, we show that the enzyme’s performance can be greatly improved by immobilization on solid supports. The best results are achieved using amino-functionalized magnetic microparticles: the immobilized enzyme retains its activity, greatly improves its thermostability (4 h at 75 °C), and can be recycled up to 8 times with a set of aromatic ethylamines. After the last reaction cycle, the overall conversion is about 90% for all tested substrates, with an aldehyde production ranging between 100 and 270 mg depending on the substrate used. As a proof concept, one of the aldehydes thus produced was successfully used for the biomimetic synthesis of a non-natural benzylisoquinoline alkaloid.     

NSCLC as the Paradigm of Precision Medicine at Its Finest: The Rise of New Druggable Molecular Targets for Advanced Disease

Standard treatment for advanced non-small cell lung cancer (NSCLC) historically consisted of systemic cytotoxic chemotherapy until the early 2000s, when precision medicine led to a revolutionary change in the therapeutic scenario. The identification of oncogenic driver mutations in EGFR, ALK and ROS1 rearrangements identified a subset of patients who largely benefit from targeted agents. However, since the proportion of patients with druggable alterations represents a minority, the discovery of new potential driver mutations is still an urgent clinical need. We provide a comprehensive review of the emerging molecular targets in NSCLC and their applications in the advanced setting.     

基于SOPC的可重构运动控制平台

用于现代运动控制领域的控制器,既需具备强大的计算能力来满足速度和精度的要求,还需具备可重构性能,以便更改或添加新功能.本文提出一种可重构运动控制平台的设计方法,本设计利用可编程片上系统(SOPC)技术,为提高计算能力,用浮点数字信号处理器(DSP)代替片上定点处理器.软件采用基于多线程的框架,比单线程的架构更具柔性.在SOPC Builder工具下对功能模块进行重新组合,可对现场可编程门阵列(FRGA)系统进行快速配置以适应新的功能需求.从算法和功能上来说,该平台具有较好的可重构性,通过对三轴铣床的控制,证明了该设计方法的可行性.     

Genomic Analysis Made It Possible to Identify Gene-Driver Alterations Covering the Time Window between Diagnosis of Neuroblastoma 4S and the Progression to Stage 4

Neuroblastoma (NB) is a tumor of the developing sympathetic nervous system. Despite recent advances in understanding the complexity of NB, the mechanisms that determine its regression or progression are still largely unknown. Stage 4S NB is characterized by a favorable course of disease and often by spontaneous regression, while progression to true stage 4 is a very rare event. Here, we focused on genomic analysis of an NB case that progressed from stage 4S to stage 4 with a very poor outcome. Array-comparative genomic hybridization (a-CGH) on tumor-tissue DNA, and whole-exome sequencing (WES) on exosomes DNA derived from plasma collected at the onset and at the tumor progression, pointed out relevant genetic changes that can explain this clinical worsening. The combination of a-CGH and WES data allowed for the identification iof somatic copy number aberrations and single-nucleotide variants in genes known to be responsible for aggressive NB. KLRB1, MAPK3 and FANCA genes, which were lost at the time of progression, were studied for their possible role in this event by analyzing in silico the impact of their expression on the outcome of 786 NB patients.     

GRC平板模板的抗折性能试验研究

通过正交试验,对影响GRC平板抗折强度的诸多因素及其水平进行了优选,找出了影响抗折强度的主要因素及其影响规律和机理。通过计算分析,给出了各影响因素的主次顺序,计算出了抗折强度与诸因素水平之间的关系。根据试验和理论计算结果,从中优选出了抗折性能较好的材料配比组合,并对其进行了指标估计。     

AGV路径规划与偏差校正研究

针对AGV(Automated Guided Vehicle)行走不平滑的问题,在研究路径对AGV行走性能影响的基础上,建立AGV几何模型,并对其进行运动学分析,结合Bezier曲线的特点和优势,运用改进的粒子群优化(improved Particle Swarm Op-timization,improved PSO)...