The influence of driver distraction on the severity of injuries sustained by teenage drivers and their passengers

Studies show that teenage drivers are at a higher risk for crashes. Opportunities to engage in technology and non-technology based distractions appear to be a particular concern among this age group. An ordered logit model was developed to predict the likelihood of a severe injury for these drivers and their passenger using a national crash database (the 2003, U.S. DOT-General Estimate System [GES]). As one would expect, speeding substantially increases the likelihood of severe injuries for teenage drivers and their passengers. The results of the analysis also reveal that teenage drivers have an increased likelihood of more severe injuries if distracted by a cell phone or by passengers than if the source of distraction was related to in-vehicle devices or if the driver was inattentive. Additionally, passengers of teenage drivers are more likely to sustain severe injuries when their driver is distracted by devices or passengers than with a non-distracted or inattentive driver. This supports the previous literature on teenage drivers and extends our understanding of injuries for this age group related to distraction-related crashes.     

Orthogonally bifunctionalised polyacrylamide nanoparticles: a support for the assembly of multifunctional nanodevices

Polyacrylamide nanoparticles bearing two orthogonal reactive functionalities were prepared by reverse microemulsion polymerisation. Water-soluble photosensitisers and peptide or carbohydrate moieties were sequentially attached to the new nanospecies by orthogonal conjugations based on copper-catalysed azide-alkyne cycloaddition and isothiocyanate chemistry.     

The case of the disappearing nitrosamines: a potentially global phenomenon

The cigarette usually carries in its smoke significant doses of carcinogenic tobacco specific nitrosamines (TSNAs), which have been implicated as causes of oral, lung, oesophageal, and pancreatic cancer. However, there is substantial variation in nitrosamine content of the smoke of modern cigarettes. This variation is both unacceptable and unnecessary, as TSNAs can be readily removed during the manufacturing process. Removing a known carcinogen needs no justification, even though proof of benefit may not be forthcoming for decades.     

Synthesis of freestanding HfO<Subscript>2</Subscript> nanostructures

Two new methods for synthesizing nanostructured HfO₂ have been developed. The first method entails exposing HfTe₂ powders to air. This simple process resulted in the formation of nanometer scale crystallites of HfO₂. The second method involved a two-step heating process by which macroscopic, freestanding nanosheets of HfO₂ were formed as a byproduct during the synthesis of HfTe₂. These highly two-dimensional sheets had side lengths measuring up to several millimeters and were stable enough to be manipulated with tweezers and other instruments. The thickness of the sheets ranged from a few to a few hundred nanometers. The thinnest sheets appeared transparent when viewed in a scanning electron microscope. It was found that the presence of Mn enhanced the formation of HfO₂ by exposure to ambient conditions and was necessary for the formation of the large scale nanosheets. These results present new routes to create freestanding nanostructured hafnium dioxide.     

A soft radio architecture for reconfigurable platforms

While many soft/software radio architectures have been suggested and implemented, there remains a lack of a formal design methodology that can be used to design and implement these radios. This article presents a unified architecture for the design of soft radios on a reconfigurable platform called the layered radio architecture. The layered architecture makes it possible to incorporate all of the features of a software radio while minimizing complexity issues. The layered architecture also enables a methodology for incorporating changes and updates into the system. An example implementation of the layered architecture on actual hardware is presented     

Confocal microscopy of human lens membranes in aged normal and nuclear cataracts

PURPOSE: To visualize the structure and determine the continuity of lipid membranes in lens fiber cells (LFCs) from human aged normal and cataractous lenses. METHODS: Thick sections from human nuclear cataracts and aged normal lenses were stained with the lipophilic probe DiI, and then analyzed by confocal microscopy. Staining patterns of membranes were observed in individual optical sections or three-dimensional projections of z-series taken in longitudinal section and cross-section of LFCs from different regions within the lens nucleus. RESULTS: DiI bound to and delineated the plasma membrane of LFCs from all regions of the lens nucleus. Three-dimensional projections of z-series from aged normal and cataractous lenses suggested that some of the stained lipid membranes were not continuous with LFC plasma membrane of cataractous lenses. CONCLUSIONS: The results obtained using these methods demonstrated that lipid membranes, discontinuous with the plasma membrane of LFCs, were indicative of a novel process occurring predominately in cataractous human lenses.     

Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppressor loci involved in colorectal cancer

Loss of heterozygosity (LOH) of markers at chromosome 8p is frequently noted in many different tumour types, including colorectal cancer. Numerous investigations indicate the presence of more than tumour suppressor gene (TSG) located on 8p. In this study, we describe a detailed LOH map in colorectal cancer and relate this to physical mapping data from reduced radiation 8p hybrids, yeast artificial chromosome (YAC) co-localisation of markers and fluorescence in situ hybridisation data. These data indicate the presence of two regions harbouring putative TSG's between the polymorphic markers for the LPL gene-D8S298 (approximately 4 Mb) and the markers D8S136-D8S137 (approximately 8 Mb). Yeast Artificial Chromosomes (YAC) have been isolated from these regions of interest to aid the localisation of the putative TSG's.