Noise adaptive optimization of matrix initialization for frequency-domain independent component analysis

Initializing an unmixing matrix is an important problem in source separation since an objective function to be optimized is typically non-convex. In this paper, we consider the problem of two-source signal separation from a two-microphone array located on a mobile device, where a point source such as a speech signal is placed in front of the array, while no information is available about another interference signal. We propose a simple and computationally efficient method for estimating the geometry and source type (a point or diffuse) of the interference signal, which allows us to adaptively choose a suitable unmixing matrix initialization scheme. Our proposed method, noise adaptive optimization of matrix initialization (NAOMI), is shown to be effective through source separation simulations.     

Arsenic Removal from Contaminated Groundwater by Zero Valent Iron: a Mechanistic and Long-Term Performance Study

The present study investigated the application of zero valent iron to remediate the arsenic in naturally contaminated groundwater. A performance evaluation was conducted in the laboratory on groundwater contaminated with artificial arsenic using sodium arsenate (Na₂HAsO₄.7H₂O) to simulate the arsenic concentration in the groundwater. Batch and column experiments were performed to evaluate the arsenic removal capacity by zero valent iron and the removal mechanism. The flow rate (up-flow mode) was maintained for 180 days in each column. The results from both the batch and the column experiments showed that more than 99% of the arsenic was removed successfully. In the column experiments, the arsenic was efficiently removed and the arsenic concentration in the treated water decreased to below the limit of 10 μg /L (WHO's standard) even when the columns were packed with only 25% ZVI by volume. We used SEM and XRD to characterize the surface morphology and the corrosion layer which formed on pristine ZVI and arsenic-treated ZVI to elucidate the arsenic removal mechanism. XRD and SEM results revealed that ZVI gradually converted to a magnetite/maghemite corrosion product mixed with lepidocrocite. Adsorption followed by co-precipitation was an important pathway to removing the arsenic by ZVI. Our results suggest that ZVI, combined with sand, is a suitable candidate for the ex-situ treatment of groundwater in the neutral pH range and in the presence of dissolved oxygen.     

Analysis of heart rate variability demonstrates effects of development on vagal modulation of heart rate in healthy children

OBJECTIVES: Analysis of heart rate variability (HRV) has been found to be a useful method of assessing cardiovascular autonomic control, but normal values for standard HRV measures in children have not been established. We analyzed HRV in 60 healthy children aged 3 to 15 years to determine normal values and to assess the effects of development on cardiac autonomic control with the use of ambulatory electrocardiographic monitoring. RESULTS: The high-frequency (HF) component, an index of cardiac autonomic tone, increased significantly with age from 3 to 6 years (p < 0.01) and decreased with age from 6 to 15 years (p < 0.01), and the magnitude of HF correlated significantly with the R-R intervals. Thus the changes in cardiac autonomic tone could be described as a simple equation using age and heart rate. CONCLUSIONS: We present normal values and changes in the cardiac autonomic system during childhood after HRV analysis, which could lead to a better understanding and treatment of cardiac disease in children.     

SODEL FET: novel channel and source/drain profile engineering schemes by selective Si epitaxial growth technology

In this paper, novel channel and source/drain profile engineering schemes are proposed for sub-50-nm bulk CMOS applications. This device, referred to as the silicon-on-depletion layer FET (SODEL FET), has the depletion layer beneath the channel region, which works as an insulator like a buried oxide in a silicon-on-insulator MOSFET. Thanks to this channel structure, junction capacitance (C/sub j/) has been reduced in SODEL FET, i.e., C/sub j/ (area) was /spl sim/0.73 fF//spl mu/m/sup 2/ both in SODEL nFET and pFET at Vbias =0.0 V. The body effect coefficient /spl gamma/ is also reduced to less than 0.02 V/sup 1/2/. Nevertheless, current drives of 886 /spl mu/A//spl mu/m (I/sub off/=15 nA//spl mu/m) in nFET and -320 /spl mu/A//spl mu/m (I/sub off/=10 nA//spl mu/m) in pFET have been achieved in 70-nm gate length SODEL CMOS with |V/sub dd/|=1.2 V. New circuit design schemes are also proposed for high-performance and low-power CMOS applications using the combination of SODEL FETs and bulk FETs on the same chip for 90-nm-node generation and beyond.     

Coronary back flow pressure is elevated in association with increased left ventricular end-diastolic pressure in humans

To clarify the effect of left ventricular (LV) diastolic pressure on the coronary pressure-flow relation in humans, the instantaneous diastolic coronary pressure-Doppler flow velocity relation was analyzed at rest and during papaverine-induced maximal vasodilation in 15 patients with angiographically normal coronary arteries. The values for slope (alpha PF) and zero-flow pressure intercept (Pzf index) of the instantaneous diastolic coronary pressure-flow velocity relation were obtained by a linear regression analysis. Although alpha PF did not correlate with LV end-diastolic pressure (EDP), the Pzf index correlated positively with LVEDP both at rest and during maximal vasodilation (r = 0.64, P < 0.05 and r = 0.58, P < 0.05, respectively). Thus, the back pressure to coronary inflow, as indicated by the Pzf index, may be elevated in patients with increased LVEDP, resulting in the rightward shift of the maximally dilated coronary pressure-flow relation and decreased maximal coronary flow and reserve at any given perfusion pressure.     

Phase-field modeling for facet dendrite growth of silicon

Dendrite growth of silicon from its undercooled melt was investigated by using the phase-field model for a faceted crystal with anisotropic interfacial energy. The phase-field parameters at the thin interface limit were derived and used in the simulation. The accuracy of the model was estimated from the calculated equilibrium interface shape. The errors in anisotropy and Gibbs-Thomson coefficient were within 1% and 10%, respectively. The growth of a silicon crystal from its undercooled melt has been analyzed and it is shown that the shape of growing crystal changes from square-like to dendritic with increase of undercooling. In a facet dendrite growth the tip grows keeping its shape and the shape is the same regardless of undercooling or growth velocity. It is also shown that there exists the scaling law between the characteristic length of the tip and growth velocity similar to that of a non-facet dendrite.     

Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA

The biological functions of nitric oxide in the neuronal system remain controversial. Using a novel fluorescence indicator, DAF-2 DA, for direct detection of NO, we examined both acute rat brain slices and organotypic culture of brain slices to ascertain NO production sites. The fluorescence intensity in the CA1 region of the hippocampus was augmented, especially after stimulation with NMDA, in acute brain slices. This NO production in the CA1 region was also confirmed in cultured hippocampus. This is the first direct evidence of NO production in the CA1 region. There were also fluorescent cells in the cerebral cortex after stimulation with NMDA. Imaging techniques using DAF-2 DA should be very useful for the clarification of neuronal NO functions.     

Enterohemorrhagic Escherichia coli O157 outbreak in Obihiro-city--biological and molecular characteristics among O157 isolates]

The outbreak of enterohaemorrhagic Escherichia coli (EHEC) O157:H7 infection in Obihiro City, Japan, occurred in late October 1996. The infection affected a total of 169 kindergarten pupils and school staff members in a private kindergarten. Twenty-one children (12.4%) progressed into hemolytic uremic syndrome (HUS). Moreover, the person-to-person infections in 9 families and the duration of excretion of EHEC in 13 patients were observed. The contaminated food was identified as the potato-salad served at lunch. Analysis of biological characteristics, the ability of toxin production, and the DNA analysis by PCR-based fingerprinting, the RAPD tests, among all clinical isolates, clarified a homologous origin of contamination.