Isolation of penicillin-resistant Streptococcus pneumoniae in Saga Medical School Hospital

A recent nationwide increase in beta-lactams-resistant Streptococcus pneumoniae has attracted a great deal of attention. We studied the drug sensitivity of S. pneumoniae isolated from various clinical specimens in Saga Medical School Hospital between April 1988 and December 1991. To determine the drug sensitivity of the strains, we used a micro-dilution method and determined the MIC. Drug resistance was evaluated using MIC of ampicillin (ABPC) as a reference MIC, and the results were roughly classified into the following three groups: sensitive (< or = 0.1 microgram/ml), moderately resistant (0.2-3.13 micrograms/ml) and highly resistant (> or = 6.25 micrograms/ml). The isolation frequency was calculated on the basis of one strain from one patient. No strain of S. pneumoniae with high resistance against ABPC was found in 1988 (94 strains of S. pneumoniae were isolated) and 1990 (115 strains isolated), but one such strain (0.8%) was found among 129 strains isolated in 1989, and 2 such strains (2.4%) among 84 strains isolated in 1991. Moderately resistant strains were isolated at the frequencies of 12.8%, 15.5%, 22.6%, and 21.4% respectively, in 1988, 1989, 1990, and 1991. A sum of the frequencies of "moderately resistant" and "highly resistant" (2.4%) strains was 23.8% in 1991. The frequency of resistant strains is increasing and the intensity of resistance is also being elevated.     

Using selective precipitant for uranyl ions — Fundamental studies for evaluating the precipitant performance

We have developed a simple reprocessing process for spent FBR fuels using N-cyclohexyl-2-pyrrolidone (NCP) which has selective precipitation ability for UO₂²⁺ ions. It was confirmed that NCP has sufficient precipitation ability for UO₂²⁺ ions, decontamination capability (separation of UO₂²⁺ from simulated fission products), and resistance to γ-ray radiation in nitric acid solutions. These findings indicate that NCP is applicable to our reprocessing process. We have also evaluated performances of other precipitants such as N-n-propyl-2-pyrrolidone (NProP), N-n-butyl-2-pyrrolidone (NBP), and N-n-butyl-2-pyridone (NBPyr). It was found that higher decontamination factors (DFs) are obtained by using NProP and NBP. This can be interpreted that the hydrophobicity of NProP and NBP is lower than that of NCP. Furthermore, we have obtained an experimental result that the resistance of NBPyr to γ-ray radiation is superior to that of NCP.     

A Knowledge Discovery System with Support for Model Selection and Visualization

The process of knowledge discovery in databases consists of several steps that are iterative and interactive. In each application, to go through this process the user has to exploit different algorithms and their settings that usually yield multiple models. Model selection, that is, the selection of appropriate models or algorithms to achieve such models, requires meta-knowledge of algorithm/model and model performance metrics. Therefore, model selection is usually a difficult task for the user. We believe that simplifying the process of model selection for the user is crucial to the success of real-life knowledge discovery activities. As opposed to most related work that aims to automate model selection, in our view model selection is a semiautomatic process, requiring an effective collaboration between the user and the discovery system. For such a collaboration, our solution is to give the user the ability to try various alternatives and to compare competing models quantitatively by performance metrics, and qualitatively by effective visualization. This paper presents our research on model selection and visualization in the development of a knowledge discovery system called D2MS. The paper addresses the motivation of model selection in knowledge discovery and related work, gives an overview of D2MS, and describes its solution to model selection and visualization. It then presents the usefulness of D2MS model selection in two case studies of discovering medical knowledge in hospital data—on meningitis and stomach cancer—using three data mining methods of decision trees, conceptual clustering, and rule induction.     

Stress distribution of coated film with a range of coated film thickness and elastic properties under a single EHL operating condition

In recent years, the techniques improving sliding performances have progressed by using coated films possessing superior tribological properties, to reduce the failures of the mechanical elements. Those techniques are often used under severe conditions such as elastohydrodynamic lubrication (EHL). In this paper, numerical three-dimensional analysis of the maximum shear stress applied into the coated film and substrate under a single EHL operating condition was performed with a range of coated film thickness and elastic properties. The strength of coated film as one of those techniques was evaluated numerically, resulting in an optimum design of coated film. As a result, coated films with a larger value of thickness and a smaller modulus of elasticity than that of substrate are preferable.     

Non-contact measurements of water jet spreading width with a laser instrument

Jet spreading width is one of the important characteristics of water jets discharging into the air. Many researchers have dealt with measuring this width, and contact measuring methods on the water jet surface were employed in a lot of the cases. In order to avoid undesirable effects caused by the contact on the jet surface, we introduce non-contact measuring methods with a laser instrument to the measurements of jet spreading width. In measurements, a transmitter emits sheet-like laser beam to a receiver. The water jet between the transmitter and the receiver interrupts the laser beam and makes a shadow. The minimum and maximum values of the shadow width are measured. In addition, pictures of the water jet are taken with a scale, and the shadow width is measured from the pictures. The experiments on various needle strokes were performed. Three kinds of width consistent with the jet structure were obtained. In the results, it can be concluded that our non-contact measuring methods are feasible. The data of jet spreading widths and jet taper were obtained and are useful for future applications.     

Control of Oxidation State of Eu Ions in Na2O–Al2O3–SiO2 Glasses

Glasses doped with well‐controlled Eu³⁺ and Eu²⁺ ions have attracted considerable interest due to the possibility of tuning the wavelength range of the emitted light from violet to red by using their ⁵D₀→⁷F_j and 5d–4f electron transitions. Glasses were prepared to dope Eu³⁺ ions in a Na₂O–Al₂O₃–SiO₂ system, and the changes in the valence state of Eu³⁺ ions and the glass structure surrounding the Eu atoms during heating under H₂ atmosphere were investigated using fluorescence spectroscopy, X‐ray absorption fine‐structure spectroscopy, and ²⁷Al magic‐angle spinning solid‐state nuclear magnetic resonance spectroscopy. The reduction behavior of Eu³⁺ ions was dependent on the Al/Na molar ratio of the glass. For Al/Na < 1, the Al³⁺ ions formed the AlO₄ network structure accompanied by the Na⁺ ions as charge compensators; the Eu³⁺ ions occupied the interstitial positions in the SiO₄ network structure and were not reduced even under heating in H₂ gas. On the other hand, in the glasses containing Al₂O₃ with the Al/Na ratio exceeding unity, the Eu³⁺ ions commenced to be coordinated by the AlO₄ units in addition to the SiO₄ network structure. When heated in H₂ gas, H₂ gas molecules reacted with the AlO₄ units surrounding Eu³⁺ ions to form AlO₆ units terminated with OH bonds, and reduced Eu³⁺ ions to Eu²⁺ via the extracted electrons.     

Preparation of bismuth nanowire encased in quartz template for Hall measurements using focused ion beam processing

ABSTRACT: Forming electrodes on opposite sides of an individual bismuth nanowire was attempted to prepare for Hall measurements. Although a 1-mm-long bismuth nanowire which is completely covered with a quartz template has been successfully fabricated to prevent oxidation, it is very difficult to attach Hall electrodes on the opposite sides of the nanowire due to the quartz covering. One side of the cylindrical quartz template was removed by polishing without exposure of the nanowire to the atmosphere; the thickness between the polished template surface and the nanowire was estimated to be several micrometers. Focused ion beam processing was successfully employed to expose both surfaces of the nanowire under high vacuum by removing part of the quartz template. A carbon thin film was then deposited in situ on the wire surface to fabricate an electrical contact on the bismuth nanowire sample. Furthermore, the energy dispersive X-ray analysis was performed to the area processed by focused ion beam, and the bismuth component of the nanowire was successfully detected. It was confirmed that the focused ion beam processing was applicable to attach electrodes to bismuth nanowire for Hall measurement.     

On the electrochemical activation of alkali-treated soft carbon for advanced electrochemical capacitors

The electrochemical activation process of the so-called “alkali-treated soft carbon” (ASC) has been examined in organic electrolyte solutions. SEM observation demonstrated that the edge plane of graphene structure of the ASC particle becomes rough after the activation, and XRD measurements indicated that the average lattice constant of graphene stacking in ASC increases after the activation process. Ex-situ ⁷Li NMR measurements proved that the insertion of cation (Li⁺) into the pore structure of ASC is associated with the activation process in the electrolyte dissolving Li salt. The pore-size distribution determined from N₂-gas adsorption for ASC electrodes before and after the electrochemical activation indicates that the pore structure becomes developed after the electrochemical polarization, especially in the pore-diameter range of 2–10 nm. A schematic model of the activation process has been presented, which includes electrochemical insertion of ions into the inside of the ASC.     

Glass-Ceramics and Solid-State Lighting

Yttrium aluminum garnet (YAG) doped with Ce³⁺ ion is known as an excellent phosphor for light-emitting diode (LED), usually used as a powder form dispersed in organic resins. We have developed translucent glass-ceramics (GC) of YAG: Ce³⁺ microcrystals in 2004. The GC sheet with half millimeter thick can work efficiently to make identical emission spectra with conventional white LED when combined with a blue LED. This report reviews the development history of the GC materials and impact for all inorganic solution for solid-state lighting.