User-centred app design for speech sound disorders interventions with tablet computers

Traditional speech and language pathology practice (SLPP) faces challenges delivering effective and timely therapy due to long waiting lists, the need for regular practice outside the clinic and a lack of children’s motivation to engage in persistent practice. Technology has untapped potential to address these issues and improve SLPP. This paper describes the design of a tablet app for delivering technology-enhanced therapy for children with speech sound disorders and investigates the impact of the use of apps on SLPP. The initial design was informed by a nation-wide survey of speech-language pathologists (SLPs). The quantitative analysis disclosed that even though SLPs positively perceive mobile technology, they do not currently fully exploit it in their practice due to a lack of apps in their native language and the limited usefulness of apps in foreign languages. Using a user-centred design process, a multidisciplinary team created three prototypes and a final version of an app that has been tested in real therapeutic sessions during everyday practice and informed by feedback from SLPs and children. The observation analysis is presented based on an adaptation of Koole’s FRAME model. The qualitative findings indicate that SLPs identify mobile apps as enabling greater mobility, allowing new therapeutic approaches, creating possibilities for practice outside the therapeutic setting and increasing children’s motivation, supporting greater persistence to practise in the context of the therapy.     

Evaluation of peach and nectarine fruit quality and correlations between sensory and chemical attributes

Sensory attributes and chemical composition in peach and nectarine fruits of nine different cultivars were evaluated and compared. The cultivars investigated in the research were: ‘Maria Marta’, ‘Romestar’, ‘325 × A/8’, ‘224 × A/13’, ‘V × S/4’, ‘Bea’, ‘Maria Aurelia’, ‘Venus’ and ‘Spring Red’. In sensory evaluation the ‘Maria Aurelia’ was the highest rated, and the ‘224 × A/13’ was the lowest. The cultivars ‘325 × A/8’, ‘224 × A/13’, ‘V × S/4’ and ‘Spring Red’ were poor in sugars; however, the ‘Spring Red’ was rich in organic acids. Similarly, the ‘Maria Aurelia’ and ‘Venus’ fruits had higher contents of organic acids and were also rich in sugars. Furthermore, the relationships among sensory and chemical attributes of fruit quality were studied. The sensory evaluations of sweetness, taste, and aroma were well correlated with some chemically measured attributes of peach and nectarine quality: sweetness was influenced by citric acid, shikimic acid and sugars/organic acids ratio; aroma was correlated with total organic acids, sucrose, sorbitol and malic acid; taste was related to malic/citric acid ratio, total sugars, sucrose, sorbitol and malic acid. The results of the research indicate that sensory evaluation provides a good tool in the quick assessment of peach and nectarine fruit quality. Copyright © 2005 Society of Chemical Industry     

Preservative Efficacy Screening of Pharmaceutical Formulations Using ATP Bioluminescence

The preservative challenge test is a method used to determine the efficacy of a preservation system in a pharmaceutical or cosmetic formulation. However, such testing is a labor-intensive, repetitive task often requiring days before results can be generated. Several alternatives to traditional colony-count techniques have been developed. A study using pure suspensions of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Candida albicans, and Aspergillus niger showed that the accuracy, repeatability, and linearity of the Pallchek? luminometer ATP bioluminescence (ATP-B) system was equivalent to the traditional colony-count method. In any case, the method proved sensitive enough to follow the effect of preservatives on a number of test microorganisms, indicating the applicability of the ATP-B method for preservative screening studies in various pharmaceutical formulations.     

Challenging the assumptions for thermal sensation scales

Scales are widely used to assess the personal experience of thermal conditions in built environments. Most commonly, thermal sensation is assessed, mainly to determine whether a particular thermal condition is comfortable for individuals. A seven-point thermal sensation scale has been used extensively, which is suitable for describing a one-dimensional relationship between physical parameters of indoor environments and subjective thermal sensation. However, human thermal comfort is not merely a physiological but also a psychological phenomenon. Thus, it should be investigated how scales for its assessment could benefit from a multidimensional conceptualization. The common assumptions related to the usage of thermal sensation scales are challenged, empirically supported by two analyses. These analyses show that the relationship between temperature and subjective thermal sensation is non-linear and depends on the type of scale used. Moreover, the results signify that most people do not perceive the categories of the thermal sensation scale as equidistant and that the range of sensations regarded as ‘comfortable’ varies largely. Therefore, challenges known from experimental psychology (describing the complex relationships between physical parameters, subjective perceptions and measurement-related issues) need to be addressed by the field of thermal comfort and new approaches developed.     

What is a proof?

To those brought up in a logic-based tradition there seems to be a simple and clear definition of proof. But this is largely a twentieth century invention; many earlier proofs had a different nature. We will look particularly at the faulty proof of Euler's Theorem and Lakatos' rational reconstruction of the history of this proof. We will ask: how is it possible for the errors in a faulty proof to remain undetected for several years-even when counter-examples to it are known? How is it possible to have a proof about concepts that are only partially defined? And can we give a logic-based account of such phenomena? We introduce the concept of schematic proofs and argue that they offer a possible cognitive model for the human construction of proofs in mathematics. In particular, we show how they can account for persistent errors in proofs.     

Binding of mercury in soils and attic dust in the Idrija mercury mine area (Slovenia)

Total Hg concentrations and Hg speciation were determined in soils and attic dust in a 160 km2 area around Idrija mercury mine. Attic dust as well as a sample of soil was collected at 100 locations. Mercury phases were separated into cinnabar and non-cinnabar compounds via a thermo-desorption technique. The amount of the non-cinnabar fraction is important since it is potentially bioavailable and results are needed for further risk assessment studies. The concentrations of Hg in attic dust are many times higher than in surrounding soils and the attic dust/soil ratio changes with distance. The highest concentration ratios were identified at the greatest distance from the source of pollution and the lowest close to the source of pollution. This confirms the impact of air emissions on the wider area around Idrija. Furthermore the spatial mercury distribution in the attic dust shows that the influence of atmospheric emissions caused by the Idrija smelter resulted in impacts on the environment on a regional scale. The portions of non-cinnabar compounds increase with distance from the mercury source in both sampling media. Non-cinnabar fractions were found to be enriched in distant areas where fine grained material was deposited. There were two different transport mechanisms of dust particles and gaseous Hg(0) during the mercury production period. Obviously coarse grained particles, with mostly cinnabar-bound Hg settled in the immediate vicinity of the smokestack of the smelter, whereas the fine grained fraction could be dispersed further ahead. This is represented by the percentage of cinnabar-bound Hg in attic dust and soil decreasing with distance from the smelter. Gaseous Hg(0) is probably bound to fine and ultrafine aerosols with longer residence time against deposition. The consequence is that fine grained material with Hg2+ and Hg0 prevails in remote localities and is bound in soils and dust with matrix and organic matter as non-cinnabar mercury compounds. The distributions of mercury species in attic dust and soils along the Idrijca River show that in the region from Idrija to Spodnja Idrija the portions of cinnabar and non-cinnabar are about equal, while in the upper and in the lower Idrijca valley non-cinnabar bound mercury prevails. The applicability of attic dust for tracing the mercury halo in the Idrija area was successfully shown.     

Astrocytic Vesicle Mobility in Health and Disease

Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5′-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions.