Analysis of permeability of food plastic monolayers to methylethylketone (2-butanone) with the aromatran®

It is very important that measurements of the diffusion of aromas and volatile substances in trace amounts (p.p.m.) through synthetic materials, such as PVC, PE and PP monolayers, be accurate and repeatable. The primary goal of this work was to familiarize ourselves with the Aromatran®, a new, fully automated analytical instrument, for the measurement of a ketone (2-butanone or MEK) at 23°C. A discussion of results is provided, along with comments on the system's userfriendliness and the cost of the tests.     

A multimodal corpus of simulated consultations between a patient and multiple healthcare professionals

Language resources for studying doctor–patient interaction are rare, primarily due to the ethical issues related to recording real medical consultations. Rarer still are resources that involve more than one healthcare professional in consultation with a patient, despite many chronic conditions requiring multiple areas of expertise for effective treatment. In this paper, we present the design, construction and output of the Patient Consultation Corpus, a multimodal corpus of simulated consultations between a patient portrayed by an actor, and at least two healthcare professionals with different areas of expertise. As well as the transcribed text from each consultation, the corpus also contains audio and video where for each consultation: the audio consists of individual tracks for each participant, allowing for clear identification of speakers; the video consists of two framings for each participant—upper-body and face—allowing for close analysis of behaviours and gestures. Having presented the design and construction of the corpus, we then go on to briefly describe how the multi-modal nature of the corpus allows it to be analysed from several different perspectives.

     

Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy

Folate receptor beta (FRβ) is a folate binding receptor expressed on myeloid lineage hematopoietic cells. FRβ is commonly expressed at high levels on malignant blasts in patients with acute myeloid leukemia (AML), as well as on M2 polarized tumor-associated macrophages (TAMs) in the tumor microenvironment of many solid tumors. Therefore, FRβ is a potential target for both direct and indirect cancer therapy. We demonstrate that FRβ is expressed in both AML cell lines and patient-derived AML samples and that a high-affinity monoclonal antibody against FRβ (m909) has the ability to cause dose- and expression-dependent ADCC against these cells in vitro. Importantly, we find that administration of m909 has a significant impact on tumor growth in a humanized mouse model of AML. Surprisingly, m909 functions in vivo with and without the infusion of human NK cells as mediators of ADCC, suggesting potential involvement of mouse macrophages as effector cells. We also found that TAMs from primary ovarian ascites samples expressed appreciable levels of FRβ and that m909 has the ability to cause ADCC in these samples. These results indicate that the targeting of FRβ using m909 has the potential to limit the outgrowth of AML in vitro and in vivo. Additionally, m909 causes cytotoxicity to TAMs in the tumor microenvironment of ovarian cancer warranting further investigation of m909 and its derivatives as therapeutic agents in patients with FRβ-expressing cancers.     

Influence of the Recycling Process on the Fire‐Retardant Properties of PP/EPR Blends

The fire‐retardant properties of a recycled poly(propylene)‐based material were investigated and compared to the non‐recycled formulation. An intrinsic intumescent system and zinc borate were used to flame‐retard these polymers. By mass loss calorimetry, the best results were obtained with 20 wt.‐% of additives. Synergisms between AP765 and ZB were observed in the non‐recycled blends but not in the recycled ones. Solid‐state NMR showed that chemical reactions during the decomposition process were leading to the formation of borophosphates, reinforcing the efficiency of the intumescent char. From a ‘physical’ point of view, it was shown that the fire retardant properties of the materials are related to the formation speed of the intumescent structure and not on the char thickness.

     

Efficient and Scalable Protocol for the Z‐Selective Synthesis of Unsaturated Esters by Horner?Wadsworth?Emmons Olefination

The synthesis of a highly Z‐selective Horner–Wadsworth Emmons (HWE) reagent from cheap and readily available starting materials on a 200‐g scale is described. The HWE reaction conditions have also been studied in order to design an efficient and scalable protocol leading to Z‐selectivities close to 95% with aromatic and aliphatic aldehydes.     

Adsorption of hydrogen gas and redox processes in clays

In order to assess the adsorption properties of hydrogen gas and reactivity of adsorbed hydrogen, we measured H(2)(g) adsorption on Na synthetic montmorillonite-type clays and Callovo-Oxfordian (COx) clayrock using gas chromatography. Synthetic montmorillonites with increasing structural Fe(III) substitution (0 wt %, 3.2 wt %, and 6.4 wt % Fe) were used. Fe in the synthetic montmorillonites is principally present as structural Fe(III) ions. We studied the concomitant reduction of structural Fe(III) in the clays using (57)Fe M?ssbauer spectrometry. The COx, which mainly contains smectite/illite and calcite minerals, is also studied together with the pure clay fraction of this clayrock. Experiments were performed with dry clay samples which were reacted with hydrogen gas at 90 and 120 °C for 30 to 45 days at a hydrogen partial pressure close to 0.45 bar. Results indicate that up to 0.11 wt % of hydrogen is adsorbed on the clays at 90 °C under 0.45 bar of relative pressure. (57)Fe M?ssbauer spectrometry shows that up to 6% of the total structural Fe(III) initially present in these synthetic clays is reduced upon adsorption of hydrogen gas. No reduction is observed with the COx sample in the present experimental conditions.     

Bioactive TiOB‐Coating on Titanium Alloy Implants Enhances Osseointegration in a Rat Model

The surface properties of titanium alloy implants for improved osseointegration in orthopaedic and dental surgery have been modified by many technologies. Hydroxyapatite coatings with a facultative integration of growth factors deposited by plasma spraying showed improved osseointegration. Our approach in order to enhance osseointegration was carried out by a surface modification method of titanium alloy implants called plasma chemical oxidation (PCO). PCO is an electrochemical procedure that converts the nm‐thin natural occurring titanium‐oxide layer on an implant to a 5 µm thick ceramic coating (TiOB‐surface). Bioactive TiOB‐surfaces have a porous microstructure and were loaded with calcium and phosphorous, while bioinert TiOB‐surfaces with less calcium and phosphorous loadings are smooth. A rat tibial model with bilateral placement of titanium alloy implants was employed to analyze the bone response to TiOB‐surfaces in vivo. 64 rats were randomly assigned to four groups of implants: (i) pure titanium alloy (control), ii) titanium alloy, type III anodization, (iii) bioinert TiOB‐surface, and (iv) bioactive TiOB‐surface. Mechanical fixation was evaluated by pull out tests at 3 and 8 weeks. The bioactive TiOB‐surface showed significantly increased shear strength at 8 weeks compared to all other groups.