Solution of a Well-Field Design Problem with Implicit Filtering

Problems involving the management of groundwater resources occur routinely, and management decisions based upon optimization approaches offer the potential to save substantial amounts of money. However, this class of application is notoriously difficult to solve due to non-convex objective functions with multiple local minima and both nonlinear models and nonlinear constraints. We solve a subset of community test problems from this application field using MODFLOW, a standard groundwater flow model, and IFFCO, an implicit filtering algorithm that was designed to solve problems similar to those of focus in this work. While sampling methods have received only scant attention in the groundwater optimization literature, we show encouraging results that suggest they are deserving of more widespread consideration for this class of problems. In keeping with our objectives for the community problems, we have packaged the approaches used in this work to facilitate additional work on these problems by others and the application of implicit filtering to other problems in this field. We provide the data for our formulation and solution on the web.     

Amygdala Inactivation Blocks Expression of Conditioned Memory Modulation and the Promotion of Avoidance and Freezing.

Rats were exposed to shock-paired cues immediately after training on an appetitive preference task. Elevated levels of freezing in and active avoidance of the shock-paired compartment were observed, and memory for the appetitive task was improved when tested 24 hr later. Intra-amygdala muscimol injected before the posttraining exposure eliminated freezing, avoidance, and memory modulation. The blockade of both freezing and active avoidance, which involve competing behavioral tendencies, makes it unlikely that the amygdala itself generates either behavior. The elimination of conditioned memory modulation suggests that conditioned neurohormonal responses were blocked. These conditioned internal responses may comprise the intervening variable of "conditioned fear" and may promote observable behaviors, the form of which is determined by the environment in which they occur. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Field Investigation of Soil Heave by a Large Diameter Chilled Gas Pipeline Experiment, Fairbanks, Alaska

A large scale 105-m-long, 0.9-m-diam chilled pipeline experiment was conducted to assess the response of a production pipeline that transits between unfrozen (seasonally frozen) and permafrost soils in discontinuous permafrost regions. Thermal and heave characteristics of the experiment for a three-year monitoring period are reported. In response to the chilled pipeline, the progressive cooling patterns within the permafrost and unfrozen soils were different, resulting in the development of a thermal boundary at the transition zone between the two thermally different soils. The absolute maximum movement of pipeline was 0.197 m near the thermal boundary, resulting in a differential heave of 0.148 m. Three distinct heave phases were identified within the unfrozen soil. Phase 1 of the first 200 days related to penetration and heave above the groundwater table and was characterized by heave rates between 0.211 and 0.237 mm/day. Phase 2 resulted in increased ice segregation due to interaction of the freez-ing front with the groundwater table. This phase lasted from approximately day200 to day 500 and corresponded to a heave rate from 0.206 to 0.313 mm/day. Phase 3 was characterized by a further decrease in the heave rate to about 0.081 mm/day and lasted from approximately day 500 to day 1,056.     

An Exploratory Examination of Student Attitudes Toward "Impaired" Peers in Clinical Psychology Training Programs.

Do psychology students view their training programs as doing enough to appropriately identify, accommodate, and possibly dismiss students who manifest significant impairment? This study reports the general findings of an exploratory survey distributed to clinical psychology graduate students. Overall, students viewed impairment as a highly sensitive and inadequately addressed issue. Students commonly reported frustration with and concern for impaired colleagues. A few respondents indicated that the terms impaired and problem student were insensitive and that greater attention needed to be given to "impaired" training contexts. Implications regarding formal standards for interpersonal functioning and programmatic supports for students are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Longitudinal Examination of Causal Attributions and Depression Symptomatology in Rheumatoid Arthritis.

Objective: Examine longitudinal relationships between causal attributions and depression symptoms in adults with rheumatoid arthritis (RA). Study Design: Cross-lagged panel correlations tested the temporal precedence of attributions relative to depression symptoms over 1 year. Participants: Forty-two participants completed self-report instruments on 2 occasions. Main Outcome Measures: The Inventory to Diagnose Depression and the Attributional Style Questionnaire. Results: Time 1 attributions predicted increased levels of depression symptoms at Time 2 after perceived pain and disability were controlled: Time 1 depression symptoms were unrelated to Time 2 attributions. Cross-lagged correlation comparisons revealed statistical dominance for attribution-depression relationships relative to depression-attribution relationships. Conclusions: Results support cognitive diathesis conceptualizations of depression and support cognitive-behavioral treatments for depression in RA. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Wave propagation in delaminated beam

The wave propagation model investigated herein is based on the known fact that material discontinuities affect the propagation of elastic waves in solids. The change in certain material characteristics, such as a local change in stiffness or inertia caused by a crack or the presence of material damage, will affect the propagation of transmitted elastic waves and will modify the received signal. Wave frequencies associated with the highest detection sensitivity depend, among other things, on the type of structure, the type of material, and the type of damage. This paper presents a method of wave propagation, which can be further used to detect small delaminations in beam-like structures. The considered beam is modelled by spectral finite elements.     

Psychological impact of benign breast biopsy: A longitudinal, comparative study.

The impact of benign breast biopsy (BBB) on distress and perceptions of risk for breast cancer (BC) was examined. Interviews were conducted with 100 women shortly after notification of biopsy results and 4 and 8 months post-BBB. Compared with matched healthy comparison (HC) women without BBB, the BBB group evidenced greater BC-specific distress at baseline. BC-specific distress declined after BBB, remaining elevated relative to the HC group at the 8-month follow-up. Dispositional (optimism, informational coping style), demographic (education), clinical (family history of BC), and cognitive (BC risk perception) variables were associated with baseline levels of BC-specific distress or persistence of distress. Results support the monitoring process model (S. M. Miller, 1995) and the cognitive social health information processing model (S. M. Miller, Y. Shoda, & K. Hurley, 1996). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of opportunities to respond within a drill model when rehearsing sight words with a child with mental retardation.

Sight-word instruction can improve functioning with various daily, recreational, and work-related tasks among children with moderate to severe disabilities. Previous research has demonstrated the effectiveness of drill methods to teach sight words if the model contains at least 50% known items, which would also increase the number of opportunities to respond (OTR) to the target item. The current study taught five sight words each day to a child diagnosed as moderately mentally retarded using high OTR and moderate OTR conditions and a drill ratio of 10% unknown to 90% known. Results suggested that the high OTR condition led to better retention than the moderate OTR despite containing an equal ratio of unknown to known items between them. Implications for practicing school psychologists and future research are included. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Slicing Software for Model Construction

Applying finite-state verification techniques (e.g., model checking) to software requires that program source code be translated to a finite-state transition system that safely models program behavior. Automatically checking such a transition system for a correctness property is typically very costly, thus it is necessary to reduce the size of the transition system as much as possible. In fact, it is often the case that much of a program's source code is irrelevant for verifying a given correctness property.In this paper, we apply program slicing techniques to remove automatically such irrelevant code and thus reduce the size of the corresponding transition system models. We give a simple extension of the classical slicing definition, and prove its safety with respect to model checking of linear temporal logic (LTL) formulae. We discuss how this slicing strategy fits into a general methodology for deriving effective software models using abstraction-based program specialization.     

Identifying cell-to-cell variability in internalization using flow cytometry

Biological heterogeneity is a primary contributor to the variation observed in experiments that probe dynamical processes, such as the internalization of material by cells. Given that internalization is a critical process by which many therapeutics and viruses reach their intracellular site of action, quantifying cell-to-cell variability in internalization is of high biological interest. Yet, it is common for studies of internalization to neglect cell-to-cell variability. We develop a simple mathematical model of internalization that captures the dynamical behaviour, cell-to-cell variation, and extrinsic noise introduced by flow cytometry. We calibrate our model through a novel distribution-matching approximate Bayesian computation algorithm to flow cytometry data of internalization of anti-transferrin receptor antibody in a human B-cell lymphoblastoid cell line. This approach provides information relating to the region of the parameter space, and consequentially the nature of cell-to-cell variability, that produces model realizations consistent with the experimental data. Given that our approach is agnostic to sample size and signal-to-noise ratio, our modelling framework is broadly applicable to identify biological variability in single-cell data from internalization assays and similar experiments that probe cellular dynamical processes.