Interpretation time of serial chest CT examinations with stacked-metaphor workstation versus film alternator

PURPOSE: Interpretation time of serial staging chest CT cases, which each contained current and previous examinations, with a simple prototype workstation called filmstack was experimentally compared with interpretation time with a film alternator. MATERIALS AND METHODS: The filmstack displayed a "stack" of sections for each examination; user controls allowed rapid selection of preset attenuation windows and both synchronized and unsynchronized scrolling. Eight radiologists were timed as they used the filmstack and the film alternator to interpret four ergonomically complex serial CT cases. RESULTS: All reports dictated on the basis of findings with filmstack and film were of acceptable clinical accuracy. The time to examine a case with filmstack was significantly faster than the time with film, including the time to load and unload the alternator (99% confidence [P = .01]). There was no statistically significant difference in interpretation time between filmstack and prehung film. CONCLUSION: Use of a low-cost stacked CT workstation with a single 1,024 x 1,024 monitor is an effective means of interpreting cases that require comparison of multiple CT examinations.     

Travel time models for deep-lane unit-load autonomous vehicle storage and retrieval system (AVS/RS)

Autonomous vehicle storage and retrieval systems use vehicles that move horizontally along rails within the storage racks, while vertical movements are provided by lifts. The solution proposed in this paper addresses a particular system configuration that works with multiple deep storage lanes that are widely used in the food and beverage industry, characterised by large volumes of products of limited variety. The generic deep lane is single item, i.e. one stock keeping unit, and single batch, i.e. one production lot, thereby affecting the performance of the system in terms of storage capacity utilisation and throughput. Determining the number and depth of the lanes is crucial to aid the design and control of such a storage system. The aim of this paper was to support the design of AVS/RSs though a set of original analytic models for the determination of the travelled distance and time for single-command and dual-command cycles given alternative layout configurations. The models are validated by simulation and exemplified with a real-warehousing case study. The paper presents useful guidelines for the configuration of the system layout including the determination of the optimal shape ratio and the length of the lanes.     

Learning extended FSA from software: An empirical assessment

A number of techniques that infer finite state automata from execution traces have been used to support test and analysis activities. Some of these techniques can produce automata that integrate information about the data-flow, that is, they also represent how data values affect the operations executed by programs.The integration of information about operation sequences and data values into a unique model is indeed conceptually useful to accurately represent the behavior of a program. However, it is still unclear whether handling heterogeneous types of information, such as operation sequences and data values, necessarily produces higher quality models or not.In this paper, we present an empirical comparative study between techniques that infer simple automata and techniques that infer automata extended with information about data-flow. We investigate the effectiveness of these techniques when applied to traces with different levels of sparseness, produced by different software systems. To the best of our knowledge this is the first work that quantifies both the effect of adding data-flow information within automata and the effectiveness of the techniques when varying sparseness of traces.     

Design and Hydraulics of a Combined Storm Overflow Structure

Storm overflow structures in combined sewers are used to separate sewage from storm water. For subcritical approach flow, sideweirs are currently used; however, they often behave hydraulically poor. This study was conducted to explore a combined storm overflow structure able to improve the hydraulic performance of sewer sideweirs. Such a structure consists of a low-crested sideweir and a bottom opening just downstream from the sideweir end. First, the hydraulic design procedure is described, and then, based on laboratory experiments and by using the governing flow equations, the main hydraulic features are highlighted. The results indicate that the proposed device has advantageous characteristics in terms of hydraulic efficiency, reliability, and maintenance.     

Light Triggers the Antiproliferative Activity of Naphthalimide-Conjugated (η6-arene)ruthenium(II) Complexes

We report the synthesis and characterization of three half-sandwich Ru(II) arene complexes [(η⁶-arene)Ru(N,N′)L][PF₆]₂ containing arene = p-cymene, N,N′ = bipyridine, and L = pyridine meta- with methylenenaphthalimide (C1), methylene(nitro)naphthalimide (C2), or methylene(piperidinyl)naphthalimide (C3). The naphthalimide acts as an antenna for photoactivation. After 3 h of irradiation with blue light, the monodentate pyridyl ligand had almost completely dissociated from complex C3, which contains an electron donor on the naphthalimide ring, whereas only 50% dissociation was observed for C1 and C2. This correlates with the lower wavelength and strong absorption of C3 in this region of the spectrum (λ_max = 418 nm) compared with C1 and C2 (λ_max = 324 and 323 nm, respectively). All the complexes were relatively non-toxic towards A549 human lung cancer cells in the dark, but only complex C3 exhibited good photocytoxicity towards these cancer cells upon irradiation with blue light (IC₅₀ = 10.55 ± 0.30 μM). Complex C3 has the potential for use in photoactivated chemotherapy (PACT).     

Molecular Effects of Chronic Exposure to Palmitate in Intestinal Organoids: A New Model to Study Obesity and Diabetes

Intestinal cell dysfunctions involved in obesity and associated diabetes could be correlated with impaired intestinal cell development. To date, the molecular mechanisms underlying these dysfunctions have been poorly investigated because of the lack of a good model for studying obesity. The main aim of this study was to investigate the effects of lipotoxicity on intestinal cell differentiation in small intestinal organoid platforms, which are used to analyze the regulation of cell differentiation. Mouse intestinal organoids were grown in the presence/absence of high palmitate concentrations (0.5 mM) for 48 h to simulate lipotoxicity. Palmitate treatment altered the expression of markers involved in the differentiation of enterocytes and goblet cells in the early (Hes1) and late (Muc2) phases of their development, respectively, and it modified enterocytes and goblet cell numbers. Furthermore, the expression of enteroendocrine cell progenitors (Ngn3) and I cells (CCK) markers was also impaired, as well as CCK-positive cell numbers and CCK secretion. Our data indicate, for the first time, that lipotoxicity simultaneously influences the differentiation of specific intestinal cell types in the gut: enterocytes, goblet cells and CCK cells. Through this study, we identified novel targets associated with molecular mechanisms affected by lipotoxicity that could be important for obesity and diabetes therapy.     

Primary Aldosteronism and Resistant Hypertension: A Pathophysiological Insight

Primary aldosteronism (PA) is a pathological condition characterized by an excessive aldosterone secretion; once thought to be rare, PA is now recognized as the most common cause of secondary hypertension. Its prevalence increases with the severity of hypertension, reaching up to 29.1% in patients with resistant hypertension (RH). Both PA and RH are “high-risk phenotypes”, associated with increased cardiovascular morbidity and mortality compared to non-PA and non-RH patients. Aldosterone excess, as occurs in PA, can contribute to the development of a RH phenotype through several mechanisms. First, inappropriate aldosterone levels with respect to the hydro-electrolytic status of the individual can cause salt retention and volume expansion by inducing sodium and water reabsorption in the kidney. Moreover, a growing body of evidence has highlighted the detrimental consequences of “non-classical” effects of aldosterone in several target tissues. Aldosterone-induced vascular remodeling, sympathetic overactivity, insulin resistance, and adipose tissue dysfunction can further contribute to the worsening of arterial hypertension and to the development of drug-resistance. In addition, the pro-oxidative, pro-fibrotic, and pro-inflammatory effects of aldosterone may aggravate end-organ damage, thereby perpetuating a vicious cycle that eventually leads to a more severe hypertensive phenotype. Finally, neither the pathophysiological mechanisms mediating aldosterone-driven blood pressure rise, nor those mediating aldosterone-driven end-organ damage, are specifically blocked by standard first-line anti-hypertensive drugs, which might further account for the drug-resistant phenotype that frequently characterizes PA patients.     

Automatic laser-based identification for UF6 cylinders

We present a laser item identification system (L2IS), installed in a real facility on trial, that is capable of automatically monitoring all transfers of uranium hexafluoride (UF₆) cylinders between different process areas. Each cylinder has a unique ‘fingerprint’ represented by the 3D micro-structure of its surface which remains intact even under extreme environmental conditions. L2IS automatically identifies each cylinder through exploring the 3D frontal surface acquired by the laser scanner. The system is composed of a portable unit (operated in attended mode) and a fixed installed unit (operated without inspector presence). The efficiency and accuracy of our identification system were evaluated on a large dataset acquired during several years including a full year of field testing.     

Synthesis of scanning electron microscopy images by high performance computing for the metrology of advanced CMOS processes

Scanning electron microscopy is still the technique of choice for imaging and for in-line measurement of critical dimensions and overlay accuracy in most of the core technology processes. In particular, critical dimension microscopy provides information about design template matching and edge placement errors through links with design having proven beneficial effects on process yield and product reliability. In this paper, the use of high performance computing is demonstrated to simulate linescans and 2D secondary electron images to be used in optical proximity error correction strategies for nanometer scale technologies.