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排序方式: 共有1397条查询结果,搜索用时 250 毫秒
231.
232.
Fan J Deng X Gallagher JW Huang H Huang Y Wen J Ferrari M Shen H Hu Y 《Philosophical transactions. Series A, Mathematical, physical, and engineering sciences》2012,370(1967):2433-2447
Breast cancer accounted for 15 per cent of total cancer deaths in female patients in 2010. Although significant progress has been made in treating early-stage breast cancer patients, there is still no effective therapy targeting late-stage metastatic breast cancers except for the conventional chemotherapy interventions. Until effective therapy for later-stage cancers emerges, the identification of biomarkers for the early detection of tumour metastasis continues to hold the key to successful management of breast cancer therapy. Our study concentrated on the low molecular weight (LMW) region of the serum protein and the information it contains for identifying biomarkers that could reflect the ongoing physiological state of all tissues. Owing to technical difficulties in harvesting LMW species, studying these proteins/peptides has been challenging until now. In our study, we have recently developed nanoporous chip-based technologies to separate small proteins/peptides from the large proteins in serum. We used nanoporous silica chips, with a highly periodic nanostructure and uniform pore size distribution, to isolate LMW proteins and peptides from the serum of nude mice with MDA-MB-231 human breast cancer lung metastasis. By matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and biostatistical analysis, we were able to identify protein signatures unique to different stages of cancer development. The approach and results reported in this study possess a significant potential for the discovery of proteomic biomarkers that may significantly enhance personalized medicine targeted at metastatic breast cancer. 相似文献
233.
Aline P. Silva Mauro A. S. S. Ravagnani Evaristo C. BiscaiaJr. Jose A. Caballero 《Optimization and Engineering》2010,11(3):459-470
Heat exchanger network (HEN) synthesis has been a well-studied subject over the past decades. Many studies and methodologies
were proposed to make possible the energy recovery, minimizing the utilities consumption and the number of heat transfer equipment. 相似文献
234.
Mauro Comes Franchini Giovanni Baldi Daniele Bonacchi Denis Gentili Guido Giudetti Alessandro Lascialfari Maurizio Corti Patrick Marmorato Jessica Ponti Edoardo Micotti Uliano Guerrini Luigi Sironi Paolo Gelosa Costanza Ravagli Alfredo Ricci 《Small (Weinheim an der Bergstrasse, Germany)》2010,6(3):366-370
235.
Herman Jacobus Cornelis Voorwald Mauro Pedro Peres Midori Yoshikawa Pitanga Costa Maria Odila Hilário Cioffi 《Journal of Materials Science》2010,45(22):6094-6100
In spite of toxicity, hydrogen embrittlement susceptibility, and environmental issues, cadmium electroplating is usually applied
on high strength AISI 4340 aeronautical steel due to its efficient protection against electrochemical corrosion. Ion vapor
deposition (IVD) process with pure aluminum also offers good protection against corrosion with the advantages of decreasing
hydrogen embrittlement susceptibility and improving the fatigue strength of metallic components. In this research, the effects
of aluminum electroplating and IVD aluminum coating on the rotating bending fatigue strength of AISI 4340 steel were evaluated
in comparison with cadmium electroplated specimens. Experimental fatigue results showed that both aluminum electroplating
and IVD aluminum coatings are possible alternatives to cadmium electroplating. 相似文献
236.
237.
Ruffolo Silvestro A. La Russa Mauro F. Ricca Michela Belfiore Cristina M. Macchia Andrea Comite Valeria Pezzino Antonino Crisci Gino M. 《Bulletin of Engineering Geology and the Environment》2017,76(1):11-20
Bulletin of Engineering Geology and the Environment - The deterioration of a stone material is related to its pore structure, which affects the interaction between surface and environmental agents.... 相似文献
238.
In Vitro Starch Digestibility of Commercial Gluten‐Free Pasta: The Role of Ingredients and Origin
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Alessandra Marti Parisa Abbasi Parizad Mauro Marengo Daniela Erba Maria Ambrogina Pagani Maria Cristina Casiraghi 《Journal of food science》2017,82(4):1012-1019
Gluten replacement in gluten‐free (GF) products presents major challenges for the food industry in terms of sensorial, technological and nutritional characteristics. The absence of gluten reportedly affects starch digestibility, thus increasing the postprandial glycaemic response. However, the role of ingredients and processing conditions has been addressed only seldom. We investigated the in vitro starch digestibility of 9 commercial GF products (5 Italian pasta and 4 Oriental noodles) differing in formulation and processing conditions. Content of rapidly digestible starch (RDS), slowly digestible starch (SDS), and resistant starch (RS) were assessed and combined with information on starch pasting properties and on the overall protein organization. Oriental noodles presented higher relative levels of RS and RDS than Western‐style pasta, that often had SDS levels compatible with low rates of starch digestion. As regard formulation, presence of multiple ingredients seems to likely increase the RDS level, as did the different protein organization in the various samples. 相似文献
239.
Assessing the Potential Content of Ethyl Carbamate in White,Red, and Rosé Wines as a Key Factor for Pursuing Urea Degradation by Purified Acid Urease
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Martina Cerreti Marcello Fidaleo Ilaria Benucci Katia Liburdi Pasquale Tamborra Mauro Moresi 《Journal of food science》2016,81(7):C1603-C1612
The ethyl carbamate (EC) content of a wine after a given temperature‐time storage was theoretically predicted from the potential concentration of ethyl carbamate (PEC), as determined via an accelerated EC formation test. Such information was used to decide whether an enzymatic treatment was needed to reduce the wine urea level before bottling/aging. To this end, 6 white, red, and rosé wines, manufactured in Italy as such or enriched with urea, were tested for their PEC content either before or after enzymatic treatment using a purified acid urease preparation derived from Lactobacillus fermentum. The treatment was severely affected by the total phenolic content (TP) of the wine, the estimated pseudo‐first‐order kinetic rate constant for NH3 formation reducing by a factor of approximately 2000 as the TP increased from 0 to 1.64 g L‐1. Such a sensitivity to TP was by far greater than that pertaining to a killed cell‐based enzyme preparation used previously. Urea hydrolysis was successful at reducing EC concentration in wines with low levels of TP and other EC precursors. 相似文献
240.
Characterization of curdlan produced by Agrobacterium sp. IFO 13140 cells immobilized in a loofa sponge matrix,and application of this biopolymer in the development of functional yogurt
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