Algorithmen zur Pulsweitenmodulation für Wechselrichter mit in Echtzeit berechnetem Pulsmuster

Übersicht Mit Hinblick auf die zunehmend Verbreitung findende Pulsmusterberechnung in Echtzeit werden in dem Aufsatz Gesichtspunkte diskutiert, die sich aus den Eigenschaften des leistungselektronischen Stellgliedes, des Pulswechselrichters, ergeben. Die bei Abtastregelungen für die Dauer einer Abtastperiode konstante Stellgröße muß bei ihm durch Pulsweitenmodulation in ein Pulsmuster mit konstanter Amplitude und Pulsen variabler Breite umgesetzt werden. Durch ein neues Verfahren mit versetzter Abtastung haben dabei Rechentotzeiten bis zur Dauer einer halben Abtastperiode keinen Einfluß mehr auf das Pulsmuster.

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Algorithms for pulswidth modulation of inverters with online calculated pulse patterns

Contents Online calculation of pulse patterns will be employed more intensively in the future. Aspects concerning the powereleotronic circuit, the pulsewidth-modulated inverter, are to be discussed. The set value being constant for the duration of a sampling interval, has to be converted by a modulation algorithm into a pulse pattern with constant amplitude and pulses of variable width. Calculation dead-times up to half of sampling interval have no influence on the pulse pattern when using a new algorthm with shifted sampling instants.

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Herrn Prof. Dr.-Ing. Klemens Heumann zum 60. Geburtstag gewidmet     

Hospital ambulatory pediatric surgery

Since 1990, we have been conducting ambulatory pediatric surgery in an unit established solely for this purpose, supported by a team of kindergarten teachers, pediatric nurses, anesthesiologists and pediatric surgeons. This prospective investigation includes all ambulatory pediatric operations performed in our department from 1990 to 1995. In this time 3665 infants and children between the ages of 6 weeks and 18 years underwent an ambulatory operation. The ratio male to female was 4.1 to 1. The series consists of 1400 inguinal hernias, 722 inguinal testes, 191 hydroceles/funiculoceles, 75 umbilical hernias, 667 phimoses, 70 meatotomies, 59 hemangiomas, 217 endoscopies and 264 other surgical procedures. Postoperative complications defined as secondary hemorrhage, fever, obvious vomiting, urine retention and laryngospasm upon terminating anesthesia accompanied by subsequent vomiting occurred in 59 (1.6%) of all infants and children. Wound infections were seen in 0.48% (17/3517) of all patients. The recurrence rate for inguinal hernias were 0.79% and 1.12% for inguinal testes. Our experience enables us to summarize that a variety of pediatric operations can be performed today as ambulatory procedures. Nevertheless one must be prepared for the occurrence of complications and always have capacities free for inpatient care where adequate observation and treatment are available. Further improvement is necessary in quality management. In the last 20 years only a few data have been published about recurrence rates after pediatric ambulatory operations for inguinal hernias and inguinal testes. Therefore we started a prospective long- term study.     

Benign glandular inclusions in inguinal and abdominopelvic lymph nodes in gynecologic pathology

From 4 cases recently seen at the Institut Gustave-Roussy, this report describes the pathological and evolutive features of benign glandular inclusions in inguinal, pelvic or abdominal lymph nodes. These lesions are defined by the presence of tubular formations in lymph nodes, lined by a single layer of epithelium which is cuboidal or columnar and resembled that of tubal epithelium with ciliated, secretory and intercalary cells. In most cases, benign glandular inclusions in lymph nodes still quiescent. In rare instances, they may proliferate and become papillary. The association of proliferating glandular inclusions in lymph nodes with borderline tumor of the ovary raises the problem of their primary or metastatic origin. However, their pathological features argues for a primary origin in lymph nodes. Thus, we think that a metastatic potential of borderline tumors of the ovary is not supported by any convincing argument.     

Effects of ketotifen on human lymphocytes in vitro and in vivo

The effects of the antiasthmatic drug ketotifen (CAS 34580-13-7) on human mononuclear leukocytes were studied in vitro and in vivo. In vitro ketotifen concentration-dependently inhibited mitogen-stimulated lymphocyte proliferation. High ketotifen concentrations also inhibited T-lymphocyte mitogen- and adenosine triphosphate stimulated increases in intracellular Ca2+ in lymphocytes and the U937 human monocyte precursor cell line, respectively; this involved inhibition of both Ca2+ influx and intracellular mobilization. In in vivo experiments, treatment of healthy volunteers with 1 mg ketotifen b.i.d. for 7 d did not alter the number or subset composition of circulating lymphocytes. Moreover, the mitogen-stimulated in vitro proliferation of lymphocytes obtained before and after ketotifen treatment in vivo was similar. It is concluded that high ketotifen concentrations can inhibit the activation of resting lymphocytes in vitro but standard ketotifen treatment does not notably affect the number of function of circulating lymphocytes in vivo.     

Potential science-technology spillovers in regions: An insight on geographic co-location of knowledge activities in the EU

This article depicts some features of the geography of science and technology outputs in the EU, with a particular attention to regional “co-location” of these two pillars of the “knowledge-based society”. Economists have, for a decade, paid great attention to local “spillovers” stating that industrial firms often draw advantages from the presence of nearby academic centres. The presence in the same areas of strong academic and technological resources is both a condition and a result of science-technology interactions. Concentrating on publications and patents as proxies of the science and technology level in regions, we built a typology of regions according to their commitment to the two knowledge-base activities and then analysed the co-locations of science and technology from several points of view. A fine-grain lattice, mainly based on standard Nuts3 level, was used. Co-location, at the EU level, is not a general rule. A strong potential for spillover/ interaction does exist in the top-class regions which concentrate a high proportion of European S and T output. But for regions with a small/medium level of S&T activity, a divergence of orientations appears between a science-oriented family and a technology-oriented family, indicating an imbalance between local S and T resources. If we look at the S-oriented regions, whilst controlling for underlying factors, such as population and regional economic product, a significant geographic linkage between T and S appears. This suggests a trajectory of science-based technological development. A careful examination of S&T thematic alignments and specialisation is necessary to develop the hypothesis that fostering academic resources could increase the technological power along a growth path. This revised version was published online in August 2006 with corrections to the Cover Date.     

Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro

The calcium-dependent cell-cell adhesion molecule E-cadherin has been shown to counteract invasion of epithelial neoplastic cells. Using three monoclonal antibodies, we have demonstrated the presence of E-cadherin at the surface of human MCF-7/6 mammary carcinoma cells by indirect immunofluorescence coupled to flow cytometry and by immunocytochemistry. Nevertheless, MCF-7/6 cells failed to aggregate in a medium containing 1.25 mM CaCl2, and they were invasive after confrontation with embryonic chick heart fragments in organ culture. Treatment of MCF-7/6 cells with 0.5 microgram ml-1 insulin-like growth factor I (IGF-I) led to homotypic aggregation within 5 to 10 min and inhibited invasion in vitro during at least 8 days. The effect of IGF-I on cellular aggregation was insensitive to cycloheximide. However, monoclonal antibodies that interfered with the function of either the IGF-I receptor (alpha IR3) or E-cadherin (HECD-1, MB2) blocked the effect of IGF-I on aggregation. The effects of IGF-I on aggregation and on invasion could be mimicked by 1 microgram ml-1 insulin, but not by 0.5 microgram ml-1 IGF-II. The insulin effects were presumably not mediated by the IGF-I receptor, since they could not be blocked by an antibody against this receptor (alpha IR3). Our results indicate that IGF-I activates the invasion suppressor role of E-cadherin in MCF-7/6 cells.     

MODELISATION PRINCIPLES FOR DRYING OF GELS

When one wants to understand and model the drying of high water content gels, one needs to gather all thermal physical parameters and to derive a physical model based on independently measured parameters. We chose to work experimentally and theoretically on water diffusion and drying of spheres of polyacrylamide gel.

We have demonstrated the strong influence of vitreous transition on the relationship of water diffusivity with moisture content. Values of the diffusion coefficient and temperature shift factor for diffusion have been proposed.

Convective and micro-wave drying kinetics show the presence of a drying phase purely specific to radiation absorption. Finally, we have proposed a mathematical model containing independent physical parameters, which' not only predicts mass fluxes but also analyses critical physical phenomena.     

Automatic partitioning of unstructured meshes for the parallel solution of problems in computational mechanics

Most of the recently proposed computational methods for solving partial differential equations on multiprocessor architectures stem from the 'divide and conquer' paradigm and involve some form of domain decomposition. For those methods which also require grids of points or patches of elements, it is often necessary to explicitly partition the underlying mesh, especially when working with local memory parallel processors. In this paper, a family of cost-effective algorithms for the automatic partitioning of arbitrary two- and three-dimensional finite element and finite difference meshes is presented and discussed in view of a domain decomposed solution procedure and parallel processing. The influence of the algorithmic aspects of a solution method (implicit/explicit computations), and the architectural specifics of a multiprocessor (SIMD/MIMD, startup/transmission time), on the design of a mesh partitioning algorithm are discussed. The impact of the partitioning strategy on load balancing, operation count, operator conditioning, rate of convergence and processor mapping is also addressed. Finally, the proposed mesh decomposition algorithms are demonstrated with realistic examples of finite element, finite volume, and finite difference meshes associated with the parallel solution of solid and fluid mechanics problems on the iPSC/2 and iPSC/860 multiprocessors.