收费全文 | 3276篇 |
免费 | 279篇 |
国内免费 | 3篇 |
电工技术 | 43篇 |
化学工业 | 832篇 |
金属工艺 | 136篇 |
机械仪表 | 99篇 |
建筑科学 | 77篇 |
矿业工程 | 19篇 |
能源动力 | 159篇 |
轻工业 | 717篇 |
水利工程 | 15篇 |
石油天然气 | 10篇 |
无线电 | 158篇 |
一般工业技术 | 656篇 |
冶金工业 | 78篇 |
原子能技术 | 8篇 |
自动化技术 | 551篇 |
2024年 | 7篇 |
2023年 | 31篇 |
2022年 | 33篇 |
2021年 | 131篇 |
2020年 | 116篇 |
2019年 | 142篇 |
2018年 | 218篇 |
2017年 | 204篇 |
2016年 | 239篇 |
2015年 | 192篇 |
2014年 | 250篇 |
2013年 | 420篇 |
2012年 | 229篇 |
2011年 | 162篇 |
2010年 | 159篇 |
2009年 | 180篇 |
2008年 | 132篇 |
2007年 | 104篇 |
2006年 | 67篇 |
2005年 | 37篇 |
2004年 | 43篇 |
2003年 | 48篇 |
2002年 | 36篇 |
2001年 | 13篇 |
2000年 | 25篇 |
1999年 | 13篇 |
1998年 | 18篇 |
1997年 | 9篇 |
1996年 | 8篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1990年 | 15篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 18篇 |
1984年 | 27篇 |
1983年 | 31篇 |
1982年 | 18篇 |
1981年 | 20篇 |
1980年 | 20篇 |
1979年 | 17篇 |
1977年 | 8篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1974年 | 7篇 |
1973年 | 8篇 |
Objective: The aim of this article is to present technological progress in manufacturing based on continuous and semi-continuous processing of the solid oral dosage forms.
Methods: Single unit processes possessing an alternative processing pathway to batch-wise technology or, with some modification, an altered approach that may run continuously, and are thus able to seamlessly switch to continuous manufacturing are briefly presented. Furthermore, the concept of semi-continuous processing is discussed. Subsequently, more sophisticated production systems created by coupling single unit processes and comprising all the steps of production, from powder to final dosage form, were reviewed. Finally, attempts of end-to-end production approach, meaning the linking of continuous synthesis of API from intermediates with the production of final dosage form, are described.
Results: There are a growing number of scientific articles showing an increasing interest in changing the approach to the production of pharmaceuticals in recent years. Numerous scientific publications are a source of information on the progress of knowledge and achievements of continuous processing. These works often deal with issues of how to modify or replace the unit processes in order to enable seamlessly switching them into continuous processing. A growing number of research papers concentrate on integrated continuous manufacturing lines in which the production concept of “from powder to tablet” is realized. Four main domains are under investigation: influence of process parameters on intermediates or final dosage forms properties, implementation of process analytical tools, control-managing system responsible for keeping continuous materials flow through the whole manufacturing process and the development of new computational methods to assess or simulate these new manufacturing techniques. The attempt to connect the primary and secondary production steps proves that development of continuously operating lines is possible.
Conclusion: A mind-set change is needed to be able to face, and fully assess, the advantages and disadvantages of switching from batch to continuous mode production. 相似文献