A hybrid metaheuristic approach for the capacitated p-median problem

The capacitated p-median problem (CPMP) seeks to obtain the optimal location of p medians considering distances and capacities for the services to be given by each median. This paper presents an efficient hybrid metaheuristic algorithm by combining a proposed cutting-plane neighborhood structure and a tabu search metaheuristic for the CPMP. In the proposed neighborhood structure to move from the current solution to a neighbor solution, an open median is selected and closed. Then, a linear programming (LP) model is generated by relaxing binary constraints and adding new constraints. The generated LP solution is improved using cutting-plane inequalities. The solution of this strong LP is considered as a new neighbor solution. In order to select an open median to be closed, several strategies are proposed. The neighborhood structure is combined with a tabu search algorithm in the proposed approach. The parameters of the proposed hybrid algorithm are tuned using design of experiments approach. The proposed algorithm is tested on several sets of benchmark instances. The statistical analysis shows efficiency and effectiveness of the hybrid algorithm in comparison with the best approach found in the literature.     

Overshoot in the step response of fractional-order control systems

In this paper, a sufficient condition for existence of an overshoot in the step response of fractional-order systems is presented. Based on this condition, it can be shown that the existence of an overshoot in the step responses of some classes of fractional-order systems (for example, the class of fractional-order systems having commensurate orders between 1 and 2) is unavoidable. To show the usefulness of the obtained condition, this condition is applied to prove some results on the time response analysis of fractional-order control systems.     

Smart Innovation Engineering: Toward Intelligent Industries of the Future

ABSTRACT

Knowledge-based engineering systems are founded upon integration of knowledge into computer systems and are one of the core requirements for the future Industry 4.0. This paper presents a system called smart innovation engineering (SIE) capable of facilitating product innovation process semi-automatically. It enhances decision-making processes using the explicit knowledge of formal decision events. The SIE system carries the promise to support the innovation processes of manufactured products in a quick and efficient way. It stores and reuses past decisional events or sets of experiences related to innovation issues, which significantly enhances innovation progression. The analysis of basic concepts and implementation method proves that SIE system is an advanced form of cyber physical systems. It is flexible, systematic, fast, and supports customization. It can play a vital role toward Industry 4.0 development.     

Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomics Approach

A key aspect of cytokine-induced changes as observed in sepsis is the dysregulated activation of endothelial cells (ECs), initiating a cascade of inflammatory signaling leading to leukocyte adhesion/migration and organ damage. The therapeutic targeting of ECs has been hampered by concerns regarding organ-specific EC heterogeneity and their response to inflammation. Using in vitro and in silico analysis, we present a comprehensive analysis of the proteomic changes in mouse lung, liver and kidney ECs following exposure to a clinically relevant cocktail of proinflammatory cytokines. Mouse lung, liver and kidney ECs were incubated with TNF-α/IL-1β/IFN-γ for 4 or 24 h to model the cytokine-induced changes. Quantitative label-free global proteomics and bioinformatic analysis performed on the ECs provide a molecular framework for the EC response to inflammatory stimuli over time and organ-specific differences. Gene Ontology and PANTHER analysis suggest why some organs are more susceptible to inflammation early on, and show that, as inflammation progresses, some protein expression patterns become more uniform while additional organ-specific proteins are expressed. These findings provide an in-depth understanding of the molecular changes involved in the EC response to inflammation and can support the development of drugs targeting ECs within different organs. Data are available via ProteomeXchange (identifier PXD031804).     

交通量持续增长下大跨桥梁时变极值外推分析

随着交通运输行业的迅速发展,持续增长的交通荷载逐步成为威胁既有桥梁运营安全的重要因素。为了研究现有交通荷载持续增长对大跨桥梁安全水平的影响,提出考虑交通量区间增长的车载效应极值外推方法,采用基于\     

Silver-Decorated Silicon Nanostructures: Fabrication and Characterization of Nanoscale Terraces as an Efficient SERS-Active Substrate

Rich and highly dense surface-enhanced Raman (SERS) hotspots available in the SERS-active platform are highly anticipated in SERS measurements. In this work, conventional silicon wafer was treated to have wide exposure to terraces available within the silicon nanostructures (Si-NSs). High-resolution field emission scanning electron microscopic (FESEM) investigations confirmed that the terraces were several microns wide and spread over different steps. These terraces were further decorated with silver nanoparticles (Ag-NPs) of different shapes and sizes to achieve SERS-active hotspots. Based on more than 150 events, a histogram of the size distribution of Ag-NPs indicated a relatively narrow size distribution, 29.64 ± 4.66 nm. The coverage density was estimated to be ~4 × 10¹⁰ cm⁻². The SERS-activity of Ag-NPs -decorated Si-NSs was found to be enhanced with reference to those obtained in pristine Si-NSs. Finite difference time domain models were developed to support experimental observations in view of electromagnetic (EM) near-field distributions. Three archetype models; (i) dimer of same constituent Ag-NPs, (ii) dimer of different constituent Ag-NPs, and (iii) linear trimer of different constituent Ag-NPs were developed. EM near-field distributions were extracted at different incident polarizations. Si-NSs are well-known to facilitate light confinement, and such confinement can be cascaded within different Ag-NPs-decorated terraces of Si-NSs.     

Reservoir volume optimization and performance evaluation of rooftop catchment systems in arid regions: A case study of Birjand,Iran

This study evaluated the performance of rooftop catchment systems in securing non-potable water supply in Birjand, located in an arid area in southeastern Iran. The rooftop catchment systems at seven study sites of different residential buildings were simulated for dry, normal, and wet water years, using 31-year rainfall records. The trial and error approach and mass diagram method were employed to optimize the volume of reservoirs in five different operation scenarios. Results showed that, during the dry water year from 2000 to 2001, for reservoirs with volumes of 200–20000 L, the proportion of days that could be secured for non-portable water supply was on average computed to be 16.4%–32.6% across all study sites. During the normal water year from 2009 to 2010 and the wet water year from 1995 to 1996, for reservoirs with volumes of 200–20000 L, the proportions were 20.8%–69.6% and 26.8%–80.3%, respectively. Therefore, a rooftop catchment system showed a high potential to meet a significant portion of non-potable water demand in the Birjand climatic region. Reservoir volume optimization using the mass diagram method produced results consistent with those obtained with the trial and error approach, except at sites #1, #2, and #5. At these sites, the trial and error approach performed better than the mass diagram method due to relatively high water consumption. It is concluded that the rooftop catchment system is applicable under the same climatic conditions as the study area, and it can be used as a drought mitigation strategy as well.     

3D CFD validation of invert trap efficiency for sewer solid management using VOF model

Earlier investigators have numerically carried out performance analysis of the invert trap fitted in an open channel using the stochastic discrete phase model(DPM) by assuming the open channel flow to be closed conduit flow under pressure and assuming zero shear stress at the top wall.This is known as the fixed lid model.By assuming the top wall to be a shear free wall,they have been able to show that the velocity distribution looks similar to that of an open channel flow with zero velocity at the bottom and maximum velocity at the top,representing the free water surface,but no information has been provided for the pressure at the free water surface.Because of this assumption,the validation of the model in predicting the trap efficiency has performed significantly poorly.In addition,the free water surface subject to zero gauge pressure cannot be modeled using the fixed lid model because there is no provision of extra space in the form of air space for the fluctuating part of the water surface profile.It can.however,be modeled using the volume of fluid(VOF) model because the VOF model is the appropriate model for open channel or free surface flow.Therefore,in the present study,three-dimensional(3D) computational fluid dynamics(CFD) modeling with the VOF model,which considers open channel flow with a free water surface,along with the stochastic DPM.was used to model the trap efficiency of an invert trap fitted in an open rectangular channel.The governing mathematical flow equations of the VOF model were solved using the ANSYS Fluent 14.0 software,reproducing the experimental conditions exactly.The results show that the 3D CFD predictions using the VOF model closely fit the experimental data for glass bead particles.     

Determination of Polycyclic Aromatic Hydrocarbons (PAHs) in Olive and Refined Pomace Olive Oils with Modified Low Temperature and Ultrasound-Assisted Liquid–Liquid Extraction Method Followed by the HPLC/FLD

The cleanup method of modified low temperature was compared with the standardized method of modified ultrasound-assisted liquid–liquid (UALL) extraction for the analysis of 15 polycyclic aromatic hydrocarbons (PAHs) in olive oil and refined pomace olive oil. The modified UALL extraction consisted in purification on C₁₈ reversed-phase, Florisil-bonded-phase and NH₂ cartridges, and modified low-temperature extraction was followed by alumina-N and NH₂ solid-phase extraction (SPE) cartridges. Both methods are followed by reversed-phase high-performance liquid chromatography with fluorescence detection. The chromatograms of the final extracts showed lower interferences in both of the methods. The solvent consumption and cost for the modified UALL method were higher than those of the modified low temperature, and also, it needed more equipment, but its analysis time was less. The limit of detection and limit of quantitation of the modified UALL method were 0.16–0.97 and 0.57–2.93 μg kg^?1, respectively, and for the modified low temperature, they were 0.09–1.97 and 0.29–5.99 μg kg^?1, respectively. The PAH recoveries for the modified UALL extraction method ranged from 75.0 to 111.0 % (RSD?=?3–8 %), and for the modified low temperature, they ranged from 81.5 to 113.8 % (RSD?=?3–10 %).     

Debottlenecking procedure of effluent thermal treatment system

In this study pinch technology has been improved for wastewater temperature reduction. Having considered design grouping rules on the basis of pinch technology, a new debottlenecking procedure for thermal treatment of the wastewater network, has been introduced. In the presented procedure, better thermal treatment of effluent network using the new method can be used to avoid investment in new cooling tower capacity and to improve the performance of the tower in a systematic way. Related coding in Visual Sudio.Net 2003, C++, has been developed for the illustrative example to get optimal values in the cooling water design method computations.