Anticipatory dementia: a link between memory appraisals and concerns about developing Alzheimer's disease

This exploratory study examines the link between memory appraisals and personal concerns about developing Alzheimer's disease. The sample of persons ages 40-60 includes adult children with a living parent who has Alzheimer's disease (N = 25) and a matched group with no family history of dementia (N = 25). Using two composite measures of memory appraisals, the results show significant bivariate and multivariate relationships between self-assessments of memory functioning and concerns about developing the disease. The findings also suggest that negative memory appraisals evoke concerns about developing Alzheimer's disease within both of the subsamples.     

Effect of perilymphatic fistulas on evoked otoacoustic emissions in the guinea pig

Round window perilymphatic fistulas were surgically created in 20 guinea pigs. Distortion product otoacoustic emissions (DPOAEs) at 2fl - f2 were recorded prior to and immediately following laceration of the round window. The stimuli were equal level sinusoids (f1 < f2) with f2 ranging from 2 to 10 kHz, a fixed f2:f1 ratio of 1.25, and stimulus levels (L2 = L1) ranging from 20 to 80 dB SPL. After an 18-day survival period, emission measurements were repeated, and fluorescein was infused into the cerebrospinal fluid to verify patency or closure of the fistula. Nine animals demonstrated patent fistulas, whereas 11 had closed fistulas. There was a statistically significant reduction in DPOAE amplitude after an acute fistula across all stimulus levels (p < .001). At 18 days the DPOAE amplitudes in animals with healed fistulas could not be differentiated from controls, whereas DPOAE amplitudes in animals with patent fistulas were statistically different from controls (p < .05). The results suggest that evoked otoacoustic emissions may be useful in detecting perilymphatic fistulas.     

Episodes of psychiatric utilization

The continued growth of outpatient psychiatric care has been accompanied by a large number of research studies concerning the determinants of psychiatric utilization. One of the major limitations of these efforts has been the inability to go beyond distributional data on the use of services. This article describes a methodology for generating episodes of psychiatric care given a data set with a small amount of routinely collected data present in many medical information systems. Both demographic and medical characteristics are significantly associated with health services resource use as defined by the number of visits in an episode. A model predicting recurrent episodes of care is also described. The general utility of this approach and the substantive implications of the specific results are discussed.     

The biological properties of Aerococcus antagonists, representatives of human microbiocenoses

The paper deals with the data on biology of Aerococcus, a slightly studied group of microorganisms. Physiological-biochemical properties of Aerococcus are described, data of their distribution in nature are given. Peculiar attention is paid to the estimate of the role of Aerococcus in human microbiocenoses. As a result of the profound and all-round study of this group of microorganisms the authors have developed new bacterial drug "A-bakterin" based on the aerococcus strain. Data presented about the results of clinical tests of "A-bakterin" are presented, a possibility to use Aerococcus lysate in the elaboration of new drugs is discussed.     

Methods of financial analysis for the delivery of dental assistance with the obligatory health coverage

The authors offer a method for estimation of financing of dental care and differentiation of it by various sections. With detailed information at hand, it is possible to estimate the cost of a territorial program of obligatory medical insurance in dentistry by combining its various sections with consideration for the preset scope of dental care and the mean per capita standard of financing and the reserve fund.     

Angiogenesis and inflammation in invasive carcinoma of the breast

Transforming growth factor-beta (TGF-beta) plays an important role in the regulation of extracellular matrix (ECM) deposition by stimulating the synthesis of individual matrix proteins like tenascin and fibronectin. Cholesteatoma shows significant changes in the ECM, supporting the view of a disturbed cell-matrix interaction. The purpose of our present study was to evaluate the distribution of TGF-beta in comparison to the deposition of tenascin, fibronectin, and collagen as major components of the ECM in cholesteatoma (n = 12) by means of histochemistry and immunohistochemistry. We found TGF-beta in lymphocytes and fibrohistiocytes in the stroma of 7 cholesteatomas. In corresponding sections, a marked expression of tenascin and fibronectin was seen manifesting as a continuous band along the epidermal-stromal junction, extending to the deeper stroma. In addition, in those cases of TGF-beta expression, beginning collagen fibril formation was seen in adjacent deeper stroma layers, indicating beginning stromal fibrosis. These results suggest that TGF-beta may be involved in the stimulation of the synthesis of tenascin, fibronectin, and collagen. Furthermore, the enhanced expression of tenascin and fibronectin provides evidence for a deregulated cell-matrix interaction in cholesteatoma associated with the enhanced proliferative process of cholesteatoma formation.