Effects of buoyancy and conjugate heat transfer on non-Darcy mixed convection about a vertical slender hollow cylinder embedded in a porous medium with high porosity

This study investigates mixed convection heat transfer about a vertical slender hollow cylinder in the buoyancy and conjugate heat transfer effects in the porous medium with high porosity. The non-similar solutions using the Keller box method are obtained. The wall conduction parameter p, the porous medium parameter k₁, the Forchheimer parameter F∗ and the Richardson number are the main parameters. For various values of these parameters the local skin friction and local heat transfer parameters are determined. The validity of the methodology is checked by comparing the results with those available in the open literature and a fairly good agreement is observed. Finally, it is determined that the local skin friction and the local heat transfer coefficients increase with an increase buoyancy parameter Ri, porous medium parameter k₁, Forchheimer parameter F∗ and decrease with conjugate heat transfer parameter p.     

Multicriteria renewable energy planning using an integrated fuzzy VIKOR & AHP methodology: The case of Istanbul

The purpose of this study is twofold: first, it is aimed at determining the best renewable energy alternative for Istanbul by using an integrated VIKOR-AHP methodology. Second, a selection among alternative energy production sites in this city is made using the same approach. In the proposed VIKOR-AHP methodology, the weights of the selection criteria are determined by pairwise comparison matrices of AHP. In energy decision making problems, the judgments of decision makers are usually vague. As it is relatively difficult for decision makers to provide exact values for the criteria, the evaluation data for the alternative energy policies should be expressed in linguistic terms. In order to model this kind of uncertainty in human preferences, fuzzy logic is applied very successfully. Thus, both classical VIKOR and classical AHP procedures are performed under fuzzy environment. The originality of the paper comes from the application of the proposed integrated VIKOR-AHP methodology to the selection of the best energy policy and production site. It is found that wind energy is the most appropriate renewable energy option and Çatalca district is the best area among the alternatives for establishing wind turbines in Istanbul.     

A Novel Strategy as a Potential Rapid Therapy Modality in the Treatment of Corneal Ulcers: Fluconazole/Vancomycin Dual Drug-Loaded Nanofibrous Patches

Corneal ulcer, which is brought on by a breach in the epithelial barrier, is a dangerous infection of the avascular corneal stroma. New treatment strategies are needed, suppressing the aggressive nature of the disease and including a combination of different drugs. In this study, vancomycin (VAN) and fluconazole (FLU) dual-drug loaded dual-layered polyvinyl alcohol and gelatin (PVA/GEL) nanofibrous patches are produced by electrospinning. Scanning electron microscopy (SEM) images show smooth surfaces are obtained for both pure and drug-loaded nanofibrous patches. The tensile test results report that loading the FLU and VAN separately into the PVA/GEL patches decrease both the tensile strength and elongation at break and it is further reduced when combining two drug-loaded layers in one patch. According to drug release results, the FLU and VAN-loaded nanofibrous patches show a controlled release profile extending up to 96 h. Moreover, PVA/GEL/FLU, PVA/GEL/VAN, and PVA/GEL/FLU/VAN nanofibrous patches display significant antimicrobial activity against Candida albicans and Staphylococcus aureus. SEM, 4'-6diamidynofenyloindol (DAPI) staining, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay show that PVA/FLU and PVA/GEL/FLU/VAN nanofibrous patches have a superior effect on NIH3T3 cell spreading and proliferation. The novelty of this study lays in the development of a potential dual drug rapid treatment for corneal ulcers of aggressive nature.     

Rapid Biocatalytic Synthesis of Aromatic Acid CoA Thioesters by Using Microbial Aromatic Acid CoA Ligases

Chemically labile ester linkages can be introduced into lignin by incorporation of monolignol conjugates, which are synthesized in planta by acyltransferases that use a coenzyme A (CoA) thioester donor and a nucleophilic monolignol alcohol acceptor. The presence of these esters facilitates processing and aids in the valorization of renewable biomass feedstocks. However, the effectiveness of this strategy is potentially limited by the low steady-state levels of aromatic acid thioester donors in plants. As part of an effort to overcome this, aromatic acid CoA ligases involved in microbial aromatic degradation were identified and screened against a broad panel of substituted cinnamic and benzoic acids involved in plant lignification. Functional fingerprinting of this ligase library identified four robust, highly active enzymes capable of facile, rapid, and high-yield synthesis of aromatic acid CoA thioesters under mild aqueous reaction conditions mimicking in planta activity.