On transmission zeros and zero directions of multivariable time-invariant linear systems with input-derivative control

The purpose of this paper is to investigate the problem of finding inputs which generate zero outputs in linear systems whose state equation contains the derivative of the input. The method developed makes use of the simplest matrix generalized inverse, the {1}-inverse.     

On sufficient conditions for the stability of interval matrices

Using Gershgorin's diagonal dominance theorem, new sufficient conditions for the stability of interval matrices are obtained. The new conditions remove a restriction in Heinen's (1983) analysis and are applicable to a wider class of problems than previously possible.     

核电结构材料应力腐蚀开裂初始阶段裂尖驱动力的研究

裂尖力学状态是影响核电结构材料应力腐蚀开裂(SCC)扩展速率的主要因素之一。为了搞清SCC不同扩展阶段裂尖驱动力的变化及其对SCC扩展速率的影响,本文建立了SCC扩展不同阶段的有限元模型,详细分析了裂纹初始阶段影响裂尖应力状态的工作载荷、残余应力,以及氧化膜形成过程中产生的膜致应力。结果表明,在SCC裂纹初始阶段,裂尖氧化膜形成所产生的“锲入张力”是SCC的主要驱动力;随着裂纹的扩展,工作载荷和残余应力逐渐成为SCC裂纹扩展的主要驱动力。     

冷轧加工纳米结构Ti_(50)Ni_(48)Co_2形状记忆合金的超弹性行为（英文）

研究冷轧后退火对Ti_(50)Ni_(48)Co_2形状记忆合金显微组织演化和超弹性性能的影响。结果表明,在冷轧制过程中,合金的显微组织经历了应力诱导马氏体相变和马氏体塑性变形、变形孪晶、马氏体中沿孪晶和不同晶界的位错堆积、纳米晶化、非晶化以及马氏体向奥氏体的可逆相变6个基本阶段。在400℃退火1 h后,冷轧样品中形成的非晶相完全晶化,生成了一个完全纳米晶体的结构。这种纳米晶体合金的峰应力高达730 MPa,明显高于粗晶Ni_(50)Ti_(50)和Ti_(50)Ni_(48)Co_2合金。而且,纳米晶Ti_(50)Ni_(48)Co_2合金具有较高的阻尼容量和较好的储能效率。     

Influence of starter culture type and incubation temperatures on rheology and microstructure of low fat set yoghurt

The effects of different cultures and incubation temperatures on the physical properties of low fat yoghurts were investigated. The samples were incubated with exopolysaccharide (EPS)-producing and non-EPS-producing cultures at 37, 42 and 45°C. All measured parameters except firmness were influenced by culture type and incubation temperature. Firmness, G' and G" were maximised at 42°C for both cultures. Increased incubation temperature and EPS culture led to a higher water-holding capacity but lower syneresis, G' and G". The EPS treatment incubated at 37°C showed even lower syneresis than non-EPS treatments incubated at higher temperatures.     

Biogenic amines in Iranian white brine cheese: modelling and optimisation of processing factors

The simultaneous effects of processing factors such as ripening time (25–75 days), ripening temperature (4–14 °C) and brine concentration (10–13%) on biogenic amines content, proteolysis and sensory score of Iranian white brine cheese were studied, in 12 cheeses. Response surface methodology (RSM) was used to minimise biogenic amines content. At low level of ripening time, biogenic amines content decreased with increasing levels of brine concentration but at high level of ripening time, brine concentration had inverse effect. Ripening time showed quadratic effect on biogenic amines content. Based on biogenic amines content and sensory score, the optimum conditions were 13% brine and ripening at 9–14 °C for 43–65 days.     

Anti-proliferative effects of a small molecule inhibitor of CDK AT7519 on chronic myeloid leukemia (CML) cells through halting the transition of cells from G2/M phase of the cell cycle

Pathogenesis of chronic myeloid leukemia (CML) has mostly been studied with regard to the oncogenic role of BCR/ABL fusion; however, recent disclosures have declared that the challenges with the treatment of CML patients would not be resolved until the role of other aberrancies is ignored. Given the involvement of cyclin-dependent kinases (CDKs) in the pathogenesis of CML, the present study aimed to investigate the effects of a multi-CDK inhibitor AT7519 on BCR/ABL-harboring CML-derived K562 cells. Our results showed that AT7519 effectively reduced the survival of K562 and induced its anti-proliferative effect through the induction of G2/M arrest due to elevated p21 and p27. The resulting data also revealed that either direct or indirect suppression of c-Myc using specific c-Myc inhibitor 10058-F4 and selective PI3K inhibitor CAL-101 resulted in a superior cytotoxicity, suggesting that the activation of PI3K pathway could attenuate antileukemic effects of the inhibitor, at least partly, through a c-Mycdependent mechanism. To the best of our knowledge, to date, no study has addressed the effect of autophagy on CML cell response to AT7519, and, herein, we proposed for the first time that the suppression of autophagy boosted AT7519 cytotoxicity against K562. Overall, we suggested that selective CDK inhibitor AT7519 exerted antileukemic effect against CML cells and propose a novel therapeutic application for the inhibitor either as a single agent or in combination with c-Myc and/or PI3K inhibitors.