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11.
Parkinson’s disease (PD) is an age-related neurodegenerative ailment that affects dopamine-producing neurons in a specific area of the brain called the substantia nigra of the ventral midbrain. It is clinically characterized by movement disorder and marked with unusual synaptic protein alpha-synuclein accumulation in the brain. To date, only a few Food and Drug Administration (FDA) approved drugs are available on the market for the treatment of PD. Nonetheless, these drugs show parasympathomimetic related adverse events and remarkably higher toxicity; hence, it is important to find more efficacious molecules to treat PD. In our study, We chosen 22 natural compounds as inhibitors that potentially block the alpha-synuclein clump—the pathological hallmark of PD—and provide new avenues for its treatment. Most of these molecules exhibited good pharmacokinetic behaviors, making them decisively favorable drug candidates to cure PD. Molecular docking studies were performed to investigate the binding interactions between natural compounds and alpha-synuclein as anti-Parkinson drug targets. Among the examined compounds, curcumin and piperine emerged as promising phytochemicals with the highest binding affinity, key residual stable bindings and showed a good inhibitory features. Thus, the present study indicates that curcumin and piperine hold the potential to be developed as treatment options against PD. Experimental validations are needed for insights into their mechanism of action and potential clinical application. 相似文献
12.
Irfan JAMIL Irshad AHMAD Aqeel Ur REHMAN Aqib AHMED Ameer HAMZA Wali ULLAH 《Frontiers of Structural and Civil Engineering》2022,16(11):1415
With increasing population and limitation of availability of land, tall buildings supported on piled raft foundations are increasingly used in the modern world. To increase the ratio of floor area to height, and to fulfill storage and parking facilities requirements, these tall buildings usually have more than one basement level. Conventionally, during the foundation design, engineers have not considered the basement wall contribution to resisting lateral load induced by earthquake or wind and this can result in an uneconomical construction of foundations. In this research work, an experimental study was performed on small-scale models, in order to study basement wall contribution, and the raft contribution including for piled raft foundations, to resisting lateral load. Three configurations of piles in 2 × 2, 2 × 3, and 3 × 3 patterns were tested as a pile group, piled raft and piled raft with a basement wall. Results show that when a basement wall is present, the lateral displacement decreases and the demand on each pile decreases. The piled raft design can become more economical for tall buildings if the basement’s walls are taken into account. 相似文献
13.
Kaitong DANG Liyong JIANG Muhammad Shemyal NISAR Xiangwei ZHAO Yujun CUI 《光子传感器（英文版）》2020,(4):364-374
Zero-mode waveguides have become important tools for the detection of single molecules.There are still,however,serious challenges because large molecules need t... 相似文献
14.
N. U. REHMAN F. U. KHAN S. NASEER G. MURTAZA S. S. HUSSAIN I. AHMAD M. ZAKAULLAH 《等离子体科学和技术》2011,13(2):208-212
Optical emission spectroscopic measurement of trace rare gas is carried out to determine the density of nitrogen (N) atom, in a nitrogen plasma, as a function of filling pressure and RF power applied. 2% of argon, used as an actinometer, is mixed with nitrogen. In order to normalize the changes in the excitation cross section and electron energy distribution function at different operational conditions, the Ar-I emission line at 419.83 nm is used, which is of nearly the same excitation efficiency coefficients as that of the nitrogen emission line at 493.51 nm. It is observed that the emission intensity of the selected argon and atomic nitrogen lines increases with both pressure and RF power, as does the nitrogen atomic density. 相似文献
15.
AHMAD Aldarouich 《计算机辅助绘图.设计与制造(英文版)》2008,(2)
Motion control can be considered as the synergistic collaboration of mechanical and electrical engineering, computer science and information technology to apply a controlled force to achieve useful motion in fluid or soiled electromechanical systems. With the development of computer, electronics, and automatic control theory, motion control comes to a new stage. Great applications are based on the characteristics, stemming from advantages of electronics and modern control technology achievements, having a v... 相似文献
16.
JUDY A. DRISKELL MARTIN J. MARCHELLO DAVID W. GIRAUD AHMAD SULAEMAN 《Journal of food quality》2004,27(5):388-398
Individual ribeye cuts from 10 grass‐ and 8 grain‐finished bulls of the same herd were analyzed for vitamin and selenium content. Vitamin A, vitamin E, thiamin, vitamin B6, vitamin B12 and selenium concentrations of ribeye cuts from grass‐ and grain‐finished bulls were similar. Vitamin C and folic acid levels were not detectable in ribeyes from both groups. Ribeyes from grass‐finished bulls contained significantly higher quantities of β‐carotene (P < 0.0005) and niacin (P < 0.01) and significantly lower (P < 0.0001) quantities of riboflavin than those from grain‐finished bulls. Bison ribeyes from both groups were rich sources (>20% Daily Values) of vitamin B12 and selenium and good sources (10–19% Daily Values) of thiamin, niacin and vitamin B6. 相似文献
17.
Mahmood AHMAD Xiao-Wei TANG Jiang-Nan QIU Feezan AHMAD Wen-Jing GU 《Frontiers of Structural and Civil Engineering》2020,14(6):1476-1491
The unprecedented liquefaction-related land damage during earthquakes has highlighted the need to develop a model that better interprets the liquefaction land damage vulnerability (LLDV) when determining whether liquefaction is likely to cause damage at the ground’s surface. This paper presents the development of a novel comprehensive framework based on select case history records of cone penetration tests using a Bayesian belief network (BBN) methodology to assess seismic soil liquefaction and liquefaction land damage potentials in one model. The BBN-based LLDV model is developed by integrating multi-related factors of seismic soil liquefaction and its induced hazards using a machine learning (ML) algorithm-K2 and domain knowledge (DK) data fusion methodology. Compared with the C4.5 decision tree-J48 model, naive Bayesian (NB) classifier, and BBN-K2 ML prediction methods in terms of overall accuracy and the Cohen’s kappa coefficient, the proposed BBN K2 and DK model has a better performance and provides a substitutive novel LLDV framework for characterizing the vulnerability of land to liquefaction-induced damage. The proposed model not only predicts quantitatively the seismic soil liquefaction potential and its ground damage potential probability but can also identify the main reasons and fault-finding state combinations, and the results are likely to assist in decisions on seismic risk mitigation measures for sustainable development. The proposed model is simple to perform in practice and provides a step toward a more sophisticated liquefaction risk assessment modeling. This study also interprets the BBN model sensitivity analysis and most probable explanation of seismic soil liquefied sites based on an engineering point of view. 相似文献
18.
Mohammad Alhuyi NAZAR ;Mohammad H. AHMAD ;Milad SADEGHZADE ;Mohammad Behshad SHAFI ;Marjan GOODARZ 《中南大学学报(英文版)》2019,26(5)
Nanotechnology is widely used in heat transfer devices to improve thermal performance. Nanofluids can be applied in heat pipes to decrease thermal resistance and achieve a higher heat transfer capability. In the present article, a comprehensive literature review is performed on the nanofluids’ applications in heat pipes. Based on reviewed studies, nanofluids have a high capacity to boost the thermal behavior of various types of heat pipes such as conventional heat pipes, pulsating heat pipes, and thermosyphons. Besides, it is observed that there must be a selected amount of concentration for the high-performance utilization of nanoparticles; high concentration of nanoparticles causes a higher thermal resistance which is mainly attributed to increment in the dynamic viscosity and the higher possibility of particles’ agglomeration. Enhancement in heat transfer performance is the result of increasing in nucleation sites and the intrinsically greater nanofluids’ thermal conductivity. 相似文献
19.
The effect of the grounded electrode diameter on the ignition voltage using 13.56 MHz in argon gas is studied experimentally. The results indicate a systematic decrease of the breakdown voltage with increasing electrode area for the same pd value. No multi-valued breakdown voltages are observed. The Paschen minimum is not affected by the electrode diameter as long as the parallel plane approximation is valid. A modified Paschen equation which takes into account indirect discharge via the chamber walls at high pd values gives reasonable fits to the experimental data. 相似文献
20.
S HUSSAIN A QAYYUM Z AHMAD S AHMAD R KHAN M A NAVEED R ALI F DEEBA G M VOROBYOV GLAST Team 《等离子体科学和技术》2017,19(8):85103
This work presents the first electrical and optical measurements of the initial phase of hydrogen discharge in the upgraded spherical tokamak GLAST-III, initiated with electron cyclotron heating (ECH). Diagnostic measurements provide insights into expected and unexpected physics issues related to the initial phase of discharge. A triple Langmuir probe (TLP) has been developed to measure time series of the floating potential, plasma electron temperature and number density over the entire discharge, allowing monitoring of the two phases of the discharge: the ECH pre-ionization phase following by the plasma current formation phase. A TLP has the ability to give time-resolved measurements of the floating potential (Vfloat), electron temperature (Te) and ion saturation current (Isat∝ ne√kTe). The evolution of the ECH-assisted pre-ionization and subsequent plasma current phases in one shot are well envisioned by the probe. Intense fluctuations in the plasma current phase advocate for efficient equilibrium and feedback control systems. Moreover, the emergence of some strong impurity lines in the emission spectrum, even after only a few shots, suggests a crucial need for improvements in the base vacuum level. A noticeable change in the shape of the temporal profiles of the floating potential, electron temperature, ion saturation current (Isat) and light emission has been observed with changing hydrogen fill pressure and vertical magnetic field. 相似文献