On the prediction of gas hold-up in two-phase flow systems using an Euler–Euler model

We quantify the ability of the two-fluid Euler–Euler model to predict the overall gas hold-up during two-phase flow in vertical columns using a combination of experiments and simulations. Gas hold-up in a bubble column and gas hold-up in the less-frequently studied co-current flow are investigated. For homogeneous flow characterized by nearly uniform bubble size, Euler–Euler model predictions are within 10% of the experimental values for both modes of operation, if the bubble diameter supplied as input to the model is the average bubble diameter in the physical system. This also holds true for heterogeneous flow in bubble columns despite the presence of a broad distribution of bubble sizes, if turbulence and bubble swarm effects on momentum exchange between phases are properly accounted for. Swarm corrections adequate for bubble columns, are less successful for co-current heterogeneous flow, for which gas hold-up predictions are least accurate (average error of 22%).     

Tea and coffee consumption in relation to vitamin D and calcium levels in Saudi adolescents

ABSTRACT: BACKGROUND: Coffee and tea consumption was hypothesized to interact with variants of vitamin D-receptor polymorphisms, but limited evidence exists. Here we determine for the first time whether increased coffee and tea consumption affects circulating levels of 25-hydroxyvitamin D in a cohort of Saudi adolescents. METHODS: A total of 330 randomly selected Saudi adolescents were included. Anthropometrics were recorded and fasting blood samples were analyzed for routine analysis of fasting glucose, lipid levels, calcium, albumin and phosphorous. Frequency of coffee and tea intake was noted. 25-hydroxyvitamin D levels were measured using enzyme-linked immunosorbent assays. RESULTS: Improved lipid profiles were observed in both boys and girls, as demonstrated by increased levels of HDL-cholesterol, even after controlling for age and BMI, among those consuming 9--12 cups of coffee/week. Vitamin D levels were significantly highest among those consuming 9--12 cups of tea/week in all subjects (p-value 0.009) independent of age, gender, BMI, physical activity and sun exposure. CONCLUSION: This study suggests a link between tea consumption and vitamin D levels in a cohort of Saudi adolescents, independent of age, BMI, gender, physical activity and sun exposure. These findings should be confirmed prospectively.     

Synthesis and Characterization of Privileged Monodentate Phosphoramidite Ligands and Chiral Brønsted Acids Derived from d-Mannitol

The synthesis of several novel chiral phosphoramidite ligands (L1–L8) with C₂ symmetric, pseudo C₂ symmetric secondary amines and chiral Brønsted acids 1a,b has been achieved. These chiral auxiliaries were obtained from commercially available d-mannitol, and secondary amines in moderate to excellent yields. Excellent diastereoselectivites of ten chiral auxiliaries were obtained. The chiral phosphoramidite ligands and chiral Brønsted acids were fully characterized by spectroscopic methods.     

Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators

Previously, we reported the identification of a thiazolidinedione‐based adenosine monophosphate activated protein kinase (AMPK) activator, compound 1 (N‐[4‐({3‐[(1‐methylcyclohexyl)methyl]‐2,4‐dioxothiazolidin‐5‐ylidene}methyl)phenyl]‐4‐nitro‐3‐(trifluoromethyl)benzenesulfonamide), which provided a proof of concept to delineate the intricate role of AMPK in regulating oncogenic signaling pathways associated with cell proliferation and epithelial–mesenchymal transition (EMT) in cancer cells. In this study, we used 1 as a scaffold to conduct lead optimization, which generated a series of derivatives. Analysis of the antiproliferative and AMPK‐activating activities of individual derivatives revealed a distinct structure–activity relationship and identified 59 (N‐(3‐nitrophenyl)‐N′‐{4‐[(3‐{[3,5‐bis(trifluoromethyl)phenyl]methyl}‐2,4‐dioxothiazolidin‐5‐ylidene)methyl]phenyl}urea) as the optimal agent. Relative to 1 , compound 59 exhibits multifold higher potency in upregulating AMPK phosphorylation in various cell lines irrespective of their liver kinase B1 (LKB1) functional status, accompanied by parallel changes in the phosphorylation/expression levels of p70S6K, Akt, Foxo3a, and EMT‐associated markers. Consistent with its predicted activity against tumors with activated Akt status, orally administered 59 was efficacious in suppressing the growth of phosphatase and tensin homologue (PTEN)‐null PC‐3 xenograft tumors in nude mice. Together, these findings suggest that 59 has clinical value in therapeutic strategies for PTEN‐negative cancer and warrants continued investigation in this regard.     

Rheological,Thermodynamic, and Gas Solubility Properties of Phenylacetic Acid‐Based Deep Eutectic Solvents

Choline chloride + phenylacetic acid‐based deep eutectic solvents are studied. Their most relevant experimental physicochemical properties at different mixing ratios together with the CO₂ solubility data obtained in wide pressure and temperature ranges are reported. The presented materials exhibit a significant CO₂ capture performance with low corrosion effect when compared with the most common amine‐based CO₂ capture agents. Detailed rheological measurements are carried out and various models are applied to describe the dynamic flow behavior of the solvents. The CO₂ absorption mechanism is evaluated by studying the behavior of the liquid gas and interface. Due to the advantages of low cost, nontoxicity, and favorable physical properties, these solvents are an environmentally promising alternative for effective CO₂ capture technological applications.     

Graphene network enabled high speed electrical actuation of shape memory nanocomposite based on poly(vinyl acetate)

Here strong electroactive shape memory nanocomposites were prepared by incorporating graphene nanoplatelets into poly(vinyl acetate) (PVAc ) through the simple solvent mixing method. TEM and XRD revealed that well exfoliated graphene nanoplatelets formed a continuous network throughout the matrix with a large amount of interconnectedness. Dynamic mechanical analysis showed that the inclusion of graphene significantly improves both glassy and rubbery moduli of the matrix. Furthermore, the prepared nanocomposites demonstrated a marked electrical conductivity up to 24.7 S m^?1 and thereby surprisingly rapid electrical actuation behaviour exhibiting a 100% recovery ratio in 2.5 s. Moreover, PVAc and its nanocomposites displayed scratch self‐healing capability. This work demonstrates that the PVAc /graphene nanocomposites with high modulus and excellent electroactive shape memory performance can be a promising material in many applications such as sensors and fast deployable and actuating devices. © 2016 Society of Chemical Industry     

Stability of gravitationally unstable double diffusive transient boundary layers with variable viscosity in porous media

We study the double diffusive convection (DDC) in porous media through linear stability analysis (LSA) and direct numerical simulations (DNS). Unlike the previous studies that assume static solutal or thermal fields, the developed model is able to capture the transient behavior of both fields. We show that under the assumption of static field, the role of Lewis number cannot be distinguished. Under transient fields, we conclude that higher Lewis numbers result in earlier instability of the boundary layers. Moreover, the effect of viscosity contrast is explained in terms of the mobility of the boundary layer. The DNS results confirm the validity of LSA predictions. We also obtain the critical Rayleigh number and show that in the presence of viscosity contrast, it can be much smaller than the conventional limit of 4π². This study provides a better understanding of the transient nature of DDC in the presence of viscosity variations. © 2017 American Institute of Chemical Engineers AIChE J, 63: 2471–2482, 2017     

Core–shell hexadecane‐polyurethane nanofiber/net structured membrane: Evaluation of surfactant addition on morphology and performance

Coelectrospinning/netting or fabrication of well‐controlled nanofibers/net (NFN) within core–shell hexadecane (HD)–polyurethane (PU) nanofiber membranes is an effective strategy to improve nanostructure morphology, mechanical properties, and performance characteristics. Three types of surfactants were separately added to PU solutions in order to make controlled NFN layers within membrane structures. The experimental results indicated that the NFN layers composed of core–shell nanowires with a diameter of 20–40 nm increased significantly when a cationic surfactant was added. Also, the results confirmed that the NFN structure caused a significant increase in strength and a noticeable decrease in elongation of the membranes. The performance characteristics of the membranes, such as water vapor transmission rate and hydrostatic pressure, were not affected significantly by the addition of the cationic surfactant. The results confirmed that the mechanical properties and morphology of the core–shell HD‐PU nanofiber membranes could be controlled and tuned by the amount and type of surfactant. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45047.     

Investigation of β phase formation in piezoelectric response of electrospun polyvinylidene fluoride nanofibers: LiCl additive and increasing fibers tension

As a piezoelectric polymer, poly (vinylidene fluoride) (PVDF) is attractive in energy conversion applications between electrical and mechanical forms because of its low cost, high flexibility, and biocompatibility. The piezoelectricity of electrospun PVDF polymer is due to changes in the crystalline structure (e.g., creating the β‐phase) during the electrospinning process. This research focuses on two approaches for investigation of β Phase formation: (1) addition of LiCl in different concentrations (0.001, 0.00133, 0.002, 0.004 wt%) as inorganic salt to the polymer solution, (2) increasing tension along the fiber axis by increasing the collector drum speed during the aligning process. Performances of these structures were evaluated by using X‐ray diffraction (XRD), Fourier Transform Infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). A one‐step nano‐generator and cost‐effective package based on electrospun nanofibers was presented to measure output voltages as a performance factor. Results show that the addition of LiCl leads to β Phase formation in the crystalline structure, decreasing fiber diameter to 65 nm, and increment in the work of rupture and piezoelectric output. Moreover, the results show that increasing collector drum speed causes the alignment of β‐crystallites along the fiber axis and subsequently no considerable effect on the formation of β‐phases and output voltage. POLYM. ENG. SCI., 56:61–70, 2016. © 2015 Society of Plastics Engineers