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The assembly of viral proteins into a range of macromolecular complexes of strictly defined architecture is one of Nature's wonders. Unraveling the details of these complex structures and the associated self-assembly pathways that lead to their efficient and precise construction will play an important role in the development of anti-viral therapeutics. It will also be important in bio-nanotechnology where there is a plethora of applications for such well-defined macromolecular complexes, including cell-specific drug delivery and as substrates for the formation of novel materials with unique electrical and magnetic properties. Mass spectrometry has the ability not only to measure masses accurately but also to provide vital details regarding the composition and stoichiometry of intact, non-covalently bound macromolecular complexes under near-physiological conditions. It is thus ideal for exploring the assembly and function of viruses. Over the past decade or so, significant advances have been made in this field, and these advances are summarized in this review, which covers the literature up to the end of 2007. 相似文献
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Nicola Pellicciotta Ojus Satish Bagal Viridiana Carmona Sosa Giacomo Frangipane Gaszton Vizsnyiczai Roberto Di Leonardo 《Advanced functional materials》2023,33(39):2214801
Biohybrid microbots integrate biological actuators and sensors into synthetic chassis with the aim of providing the building blocks of next-generation micro-robotics. One of the main challenges is the development of self-assembled systems with consistent behavior and such that they can be controlled independently to perform complex tasks. Herein, it is shown that, using light-driven bacteria as propellers, 3D printed microbots can be steered by unbalancing light intensity over different microbot parts. An optimal feedback loop is designed in which a central computer projects onto each microbot a tailor-made light pattern, calculated from its position and orientation. In this way, multiple microbots can be independently guided through a series of spatially distributed checkpoints. By exploiting a natural light-driven proton pump, these bio-hybrid microbots are able to extract mechanical energy from light with such high efficiency that, in principle, hundreds of these systems can be controlled simultaneously with a total optical power of just a few milliwatts. 相似文献
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Paolini Emilio De Marinis Lorenzo Cococcioni Marco Valcarenghi Luca Maggiani Luca Andriolli Nicola 《Neural computing & applications》2022,34(18):15589-15601
Neural Computing and Applications - Photonics-based neural networks promise to outperform electronic counterparts, accelerating neural network computations while reducing power consumption and... 相似文献
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Daniele Di Gioacchino Nicola Poccia Martijn Lankhorst Claudio Gatti Bruno Buonomo Luca Foggetta Augusto Marcelli Hans Hilgenkamp 《Journal of Superconductivity and Novel Magnetism》2017,30(2):359-363
The current frontiers in the investigation of high-energy particles demand for new detection methods. Higher sensitivity to low-energy deposition, high-energy resolution to identify events and improve the background rejection, and large detector masses have to be developed to detect even an individual particle that weakly interacts with ordinary matter. Here, we will describe the concept and the layout of a novel superconducting proximity array which show dynamic vortex Mott insulator to metal transitions, as an ultra-sensitive compact radiation-particle detector. 相似文献
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Jun Zhang Xianghong Liu Giovanni Neri Nicola Pinna 《Advanced materials (Deerfield Beach, Fla.)》2016,28(5):795-831
Sensor technology has an important effect on many aspects in our society, and has gained much progress, propelled by the development of nanoscience and nanotechnology. Current research efforts are directed toward developing high‐performance gas sensors with low operating temperature at low fabrication costs. A gas sensor working at room temperature is very appealing as it provides very low power consumption and does not require a heater for high‐temperature operation, and hence simplifies the fabrication of sensor devices and reduces the operating cost. Nanostructured materials are at the core of the development of any room‐temperature sensing platform. The most important advances with regard to fundamental research, sensing mechanisms, and application of nanostructured materials for room‐temperature conductometric sensor devices are reviewed here. Particular emphasis is given to the relation between the nanostructure and sensor properties in an attempt to address structure–property correlations. Finally, some future research perspectives and new challenges that the field of room‐temperature sensors will have to address are also discussed. 相似文献
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Rocco De Nicola 《Science of Computer Programming》2010,75(6):376-397
Coordination languages are often used to describe open-ended systems. This makes it challenging to develop tools for guaranteeing the security of the coordinated systems and the correctness of their interaction. Successful approaches to this problem have been based on type systems with dynamic checks; therefore, the correctness properties cannot be statically enforced. By contrast, static analysis approaches based on Flow Logic usually guarantee properties statically. In this paper, we show how the insights from the Flow Logic approach can be used to construct a type system for statically ensuring secure access to tuple spaces and safe process migration for an extension of the language Klaim. 相似文献
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Some applications require autonomous robots to search an initially unknown environment for static targets, without any a priori information about environment structure and target locations. Targets can be human victims in search and rescue or materials
in foraging. In these scenarios, the environment is incrementally discovered by the robots exploiting exploration strategies
to move around in an autonomous and effective way. Most of the strategies proposed in literature are based on the idea of
evaluating a number of candidate locations on the frontier between the known and the unknown portions of the environment according
to ad hoc utility functions that combine different criteria. In this paper, we show some of the advantages of using a more theoretically-grounded
approach, based on Multi-Criteria Decision Making (MCDM), to define exploration strategies for robots employed in search and
rescue applications. We implemented some MCDM-based exploration strategies within an existing robot controller and we evaluated
their performance in a simulated environment. 相似文献