Standing surface waves on helium induced by second sound. Observations and calculations

Standing waves of second sound in superfluid helium deform the free helium surface. Schlieren observations on cylindrical cavities with vertical axis give the wave patterns predicted by Sorbello. Calculations and experiments show that the deformation is stationary, with only a very small time-dependent component. At low second-sound levels the wave amplitude is proportional to intensity. At higher levels the relation of wave height to second-sound intensity becomes nonlinear and when a critical value is reached, the waves break. Their height then increases abruptly, and the dominant wave number doubles.     

双螺杆反应挤出模型的研究

详细研究了双螺杆中反应挤出聚合物的动力学模型、流动模型和传热模型。通过实验得到了双螺杆反应器中聚合物的停留时间分布及平均停留时间。     

电容位移法精确测量磁性薄膜的磁致伸缩系数

介绍了一种精确测量磁性薄膜磁致伸缩系数方法－电容位移法，并自行研制组装了一套测量装置，通过误差分析，仪器的精确标定，对稀土－铁超磁致伸缩薄膜的磁致伸缩系数进行了测量，获得满意的结果。     

Neuropathology of bovine herpesvirus type 5 (BHV-5) meningo-encephalitis in a rabbit seizure model

CI-994 (acetyldinaline) is an orally active anticancer drug currently in Phase 1 clinical trials. To assess its preclinical toxicity, CI-994 was administered orally as suspensions to Wistar rats (10/sex/dose) and in capsules to beagle dogs (3/sex/dose) once daily for two weeks. Doses were 1.5, 5, and 15 mg/kg for rats (9, 30, and 90 mg/m2, respectively), and 0.5, 2, and 5 mg/kg for dogs (10, 40, and 100 mg/m2, respectively). Systemic exposure was dose-proportional based on toxicokinetic analysis in dogs. Severe clinical signs and mortality occurred at the highest dose in both species beginning on Day 10. Neutropenia, lymphocytopenia, thrombocytopenia, lymphoid depletion, bone marrow hypocellularity, and testicular degeneration were observed in both species, primarily at the mid- and high-doses. Despite continued treatment, neutrophil counts in dogs returned to control levels in Week 2. Other microscopic findings in rats included splenic hematopoietic depletion at all doses and epithelial cell necrosis in various tissues at 15 mg/kg. Additional bone marrow changes in dogs involved myeloid and megakaryocyte hyperplasia at 2 mg/kg and abnormal myeloid and megakaryocyte maturation at 2 and 5 mg/kg. Except for the testicular effects in both species, all changes were reversible within a 4-week (rat) or 9-week (dog) recovery period. The results of these studies show that target organ effects of CI-994 principally involve tissues with rapidly dividing cell populations and that bone marrow suppression is the dose-limiting toxicity. CI-994 also seems to interfere with the release and/or maturation of cells in the bone marrow.     

Hearing loss after spinal anesthesia. An audiological controlled trial

Audiological tests were conducted on 34 patients before and after undergoing an operation in spinal anaesthesia. One of these patients developed a considerable unilateral hearing loss in the low-frequency range, which persisted until an epidural blood-patch was given. Unexpectedly, we also found a general small but significant threshold shift at 500 Hz, which has never before been described in the literature. The biological mechanism is discussed, and the results suggest that the explanation of the hearing loss could be a condition similar to endolymphatic hydrops, resulting from perilymphatic hypotension due to loss of liquor during and after the spinal anaesthesia.     

Societal Safety: Concept,Borders and Dilemmas

In most industrialized countries, the end of the Cold War marked a change in focus from preparedness for war to an increasing focus on civil society's own vulnerability and safety. To meet new threats and changing risks, there is also a need for new analytical concepts. Societal safety is a concept developed in Norway during the last decade. It could be defined as: ‘The society's ability to maintain critical social functions, to protect the life and health of the citizens and to meet the citizens' basic requirements in a variety of stress situations’. It aims to be a systematic approach for understanding, mitigating and responding to social problems such as extraordinary stresses and losses, interferences in complex and mutual dependent systems, or lack of trust in vital social institutions. Future threats to society are not limited to specific sectors or areas, but stem from complex interactions amongst economic, technological, social and cultural factors. Thus, the main challenges to improve societal safety will be the ability to coordinate, organize and assign clear roles to different actors at the international, national and local levels. Societal safety has interfaces with other safety‐related areas such as national security, sustainable development, human security and incident management (handling of isolated accidents, common illness and ordinary criminal acts). Societal safety is, however, a sensitive political issue containing dilemmas and value choices that are hardly possible to perceive or solve as pure scientific problems.     

The use of capsaicin in herpes zoster ophthalmicus neuralgia

The final stage in the production of a radiotherapy treatment plan must always be an independent check that the linear accelerator settings given on the plan do in fact deliver the required dose distribution. A tool is described that enables rapid checking of diaphragm settings in relation to the patient.