Strain control and spontaneous phase ordering in vertical nanocomposite heteroepitaxial thin films

Two-phase, vertical nanocomposite heteroepitaxial films hold great promise for (multi)functional device applications. In order to achieve practical devices, a number of hurdles need to be overcome, including the creation of ordered structures (and their formation on a large scale), achieving different combinations of materials and control of strain coupling between the phases. Here we demonstrate major advances on all these fronts: remarkable spontaneously ordered structures were produced in newly predicted compositions, vertical strain was proven to dominate the strain state in films above 20 nm thickness and strain manipulation was demonstrated by selection of phases with the appropriate elastic moduli. The work opens up a new avenue for strain control in relatively thick films and also promises new forms of ordered nanostructures for multifunctional applications.     

Ionic effects on the equilibrium dynamics of DNA confined in nanoslits

The ionic effects on the dynamics and conformation of DNA in silt-like confinement are investigated. Confined lambda-DNA is considered as a model polyelectrolyte, and its longest relaxation time, diffusivity, and size are measured at a physiological ionic strength between 1.7-170 mM. DNA properties change drastically in response to the varying ionic environment, and these changes can be explained by blob theory with an electrostatically mediated effective diameter and persistence length. In the ionic range we investigate, the effective diameter of DNA that represents the electrostatic repulsion between remote segments is found to be the main driving force for the observed change in DNA properties. Our results are useful for understanding the manipulation of biomolecules in nanofluidic devices.     

Detection of single photoluminescent diamond nanoparticles in cells and study of the internalization pathway

Diamond nanoparticles are promising photoluminescent probes for tracking intracellular processes, due to embedded, perfectly photostable color centers. In this work, the spontaneous internalization of such nanoparticles (diameter 25 nm) in HeLa cancer cells is investigated by confocal microscopy and time-resolved techniques. Nanoparticles are observed inside the cell cytoplasm at the single-particle and single-color-center level, assessed by time-correlation intensity measurements. Improvement of the nanoparticle signal-to-noise ratio inside the cell is achieved using a pulsed-excitation laser and time-resolved detection taking advantage of the long radiative lifetime of the color-center excited state as compared to cell autofluorescence. The internalization pathways are also investigated, with endosomal marking and colocalization analyses. The low colocalization ratio observed proves that nanodiamonds are not trapped in endosomes, a promising result in prospect of drug delivery by these nanoparticles. Low cytotoxicity of these nanoparticles in this cell line is also shown.     

Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue

In this study, the dynamically folded conformation of squalene (SQ) is taken advantage of to link this natural compound to the anticancer nucleoside analogue gemcitabine (gem) in order to achieve the spontaneous formation of nanoassemblies (SQgem) in water. Cryogenic transmission electron microscopy examination reveals particles (104 nm) with a hexagonal or multifaceted shape that display an internal structure made of reticular planes, each particle being surrounded by an external shell. X-ray diffraction evidences the hexagonal molecular packing of SQgem, resulting from the stacking of direct or inverse cylinders. The respective volumes of the gem and SQ molecules as well as molecular modeling of SQgem suggest the stacking of inverse hexagonal phases, in which the central aqueous core, consisting of water and gem molecules, is surrounded by SQ moieties. These SQgem nanoassemblies also exhibit impressively greater anticancer activity than gem against a solid subcutaneously grafted tumor, following intravenous administration. To our knowledge, this is the first demonstration of hexagonal phase organization with a SQ derivative.     

Retrospective reports of parental physical affection and parenting style: A study of Finnish twins.

Individual differences in parenting behaviors are due, in part, to genetic factors. In the present study, the authors sought to determine whether the degree of genetic influence varied according to the type of parental behavior under consideration. A population-based sample of 2,334 pairs of Finnish twins provided ratings on the physical affection, control, abusiveness, and indifference shown by their father and mother during childhood. Genetic influences, shared environmental influences, and nonshared environmental influences accounted for a small-to-medium proportion (17%-30%), a small-to-large proportion (22%-44%), and a medium-to-large proportion (37%-55%) of the variance in each parenting measure, respectively. There were no significant differences in effect sizes for mothers and fathers or across the 4 types of parental behavior. The genetic results may reflect characteristic styles with which parents respond to genetically influenced behaviors of individuals (gene-environment correlations) or individual perceptions of this relationship (gene-person correlation processes). The findings have implications for intervention and prevention work with families and for interpretation of evidence for interactions between genes and parenting behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rehabilitation psychology: Realizing the true potential.

As the Division of Rehabilitation Psychology (Division 22) celebrates its 50th anniversary this year, this article reflects on the current status and important trends in health care and technology that are likely to have the largest impact on the science and practice of rehabilitation psychologists in the next decade. These trends include the prevalence of chronic conditions, health disparities, Operation Iraqi Freedom and Operation Enduring Freedom injuries, and caregiver burden. The implications of these trends are also discussed in the context of rehabilitation psychologists' involvement in public policy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An Effective Power-Aware At-Speed Test Methodology for IP Qualification and Characterization

Advanced nanometer technologies have led to a drastic increase in operational frequencies resulting in the performance of circuits becoming increasingly vulnerable to timing variations. The increasing process spread in advanced nanometer nodes poses considerable challenges in predicting post-fabrication silicon performance from timing models. Thus, there is a great need to qualify basic building structures on silicon in terms of critical parameters before they could be integrated within a complex System-on-Chip (SoC). The work of this paper presents a configurable circuit and an associated power-aware at-speed test methodology for the purpose of qualifying basic standard cells and complex IP structures to detect the presence of timing faults. Our design has been embedded within test-chips used for the development of the 28 nm Fully Depleted Silicon On Insulator (FD-SOI) technology node. The relevant silicon results and analysis validate the proposed power-aware test methodology for qualification and characterization of IPs and provide deeper insights for process improvements.     

A comparison framework for breathing motion estimation methods from 4-D imaging

Motion estimation is an important issue in radiation therapy of moving organs. In particular, motion estimates from 4-D imaging can be used to compute the distribution of an absorbed dose during the therapeutic irradiation. We propose a strategy and criteria incorporating spatiotemporal information to evaluate the accuracy of model-based methods capturing breathing motion from 4-D CT images. This evaluation relies on the identification and tracking of landmarks on the 4-D CT images by medical experts. Three different experts selected more than 500 landmarks within 4-D CT images of lungs for three patients. Landmark tracking was performed at four instants of the expiration phase. Two metrics are proposed to evaluate the tracking performance of motion-estimation models. The first metric cumulates over the four instants the errors on landmark location. The second metric integrates the error over a time interval according to an a priori breathing model for the landmark spatiotemporal trajectory. This latter metric better takes into account the dynamics of the motion. A second aim of this paper is to estimate the impact of considering several phases of the respiratory cycle as compared to using only the extreme phases (end-inspiration and end-expiration). The accuracy of three motion estimation models (two image registration-based methods and a biomechanical method) is compared through the proposed metrics and statistical tools. This paper points out the interest of taking into account more frames for reliably tracking the respiratory motion.