Deorthogonalization of ODS-CDMA QPSK by AM/PM Nonlinearity

When using a conventional demodulator, a sufficient condition to maintain ODS-CDMA codeword orthogonality is constant relative channel amplitude over the codeword duration. When transmitted over a memoryless, AM/PM nonlinearity channel, the chip-to-chip fluctuating amplitude of a composite ODS-CDMA QPSK waveform produces a chip-to-chip fluctuating phase that deorthogonalizes the ODS-CDMA codewords, resulting in an additional multiple access self-interference similar to that found in asynchronous DS-CDMA. For ODS-CDMA QPSK in an AM/PM nonlinearity channel, we utilize the Central Limit Theorem, derive, and evaluate: (i) an expression for the signal-to-distortion ratio at the demodulator output, (ii) an expression for the uncoded bit error probability, and (iii) an upper bound on the convolutionally-coded bit error probability. We find that the degradation to BER depends on both the AM/PM nonlinearity slope and the ODS-CDMA channel loading.     

Thermoreversible Gelcasting: A Novel Ceramic Processing Technique

A new ceramic processing method, thermoreversible gelcasting (TRG), has been developed. The method uses a gelation process that can be reversed multiple times. Two Al₂O₃ systems have been explored with the use of a specific triblock copolymer to form a binding gel network. The mixture becomes a free-flowing liquid on heating above 60°C. However, on cooling below 60°C, the slurry instantaneously transforms to a physical gel. This process can be reversed easily (essentially with an infinite processing time window) while the solvent is present in the system, which is advantageous when trying to produce high-quality dense pieces if initial casting irregularities occur. Near-theoretically dense specimens have been produced with properties consistent with reported values of high-density Al₂O₃.     

Efficient generation of a reshaped human mAb specific for the {alpha} toxin of Clostridium perfringens

We have used the technique of antibody reshaping to producea humanized antibody specific for the a toxin of Clostridiumperfringens. The starting antibody was from a mouse hybridomafrom which variable (V) region nucleo-tide sequences were determined.The complementarity-determining regions (CDRs) from these Vregions were then inserted into human heavy and light chainV region genes with human constant region gene fragments subsequentlyadded. The insertion of CDRs alone into human frameworks didnot produce a functional reshaped antibody and modificationsto the V region framework were required. With minor frameworkmodifications, the affinity of the original murine mAb was restoredand even exceeded. Where affinity was increased, an alteredbinding profile to overlapping peptides was observed. Computermodelling of the reshaped heavy chain V regions suggested thatamino acids adjacent to CDRs can either contribute to, or distort,CDR loop conformation and must be adjusted to achieve high bindingaffinity.     

Structure-activity studies of human tumour necrosis factors

The mechanism by which tumour necrosis factors (TNF and lymphotoxin,also called TNFß and TNFß respectively) exerttheir cytotoxic activity on many malignant cells, remains largelyunknown. Furthermore, the broad array of differentiation (geneinduction) and mitogenic activities towards many primary cellsis still a subject of intensive investigation. TNF is an importantmediator in inflammation, immune responses and infection-relatedphenomena and these activities contribute to the severe toxidtyseen when TNF is used as an anticancer agent. The first stepin the mechanism of action is the specific binding of the ligandto its receptors and dissection of the molecular mechanism involvedin this interaction is the subject of this review. The reasonsfor the interest in this aspect are obvious: first, the developmentof strong antagonistic TNF analogues can be useful in dampeningthe potentially lethal or debilitating effects of an overproductionof the cytokine (as in septic shock or rheumatoid arthritis).Secondly, since two distinct TNF receptors exist, constructionof TNF muteins that distinguish between both types may leadto derivatives of this plekrtropic agent with a more restrictedbiological activity pattern. Ideally, one would like to developa TNF mutant that has retained its cytotoxic action on tumourcells without inducing the deleterious systemic toxteity. Suchan optimized TNF molecule could become a potent anticancer agent     

Tracking musical patterns using joint accent structure.

Joint Accent Structure (JAS) is a construct that uses temporal relationships between different accents in a melodic pattern as indices of its complexity. The present study examines the role of different JASs in real time, attending to simple musical events. 39 adults with or without musical training were told to selectively attend to and synchronize finger taps with accents in 2 experiments that examined attentional tracking to musical patterns having a concordant or discordant JAS. Results indicate that tapping was more variable with discordant than with concordant JAS patterns, both with respect to produced inter-accent time periods and with respect to the phase of taps relative to accent onsets. These findings are interpreted in terms of real time attending and its control by event time structure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The introduction of alkyl,ester, carboxylate,amino, hydroxyl,and phosphate functional groups to the surface of polyethylene

The surface of polyethylene was derivatized with ester, carboxylate, amino, hydroxyl, and phosphate functional groups. α, ω bifunctional alkanes, containing on one end a primary amine, were coupled to oxidized polyethylene through an amide linkage. Polyethylene was first oxidized with chromic acid, the carboxylate groups were converted to the acyl chloride with phosphorus pentachloride, and then reacted with a primary amine to give the covalently bound amide. The copposing ends of the bifunctional alkanes were the methyl, tertiary amine, ester, and hydroxyl groups. The ester was converted to the carboxylate by acid cleavage and the hydroxyl group converted to the phosphate by treatment first with phosphorus oxychloride and then aqueous base. Attenuated total reflection FTIR, XPS, and pH-dependent contact angle wetting were used to characterize the surfaces. The FTIR data were used to confirm the formation of the amide and to detect an undesired carboxylate/ammonium ion complex formed in the presence of trace amounts of water. XPS data were used to confirm expected changes in elemental composition and to provide quantitative estimates of the yields. Oxidation of the polyethylene introduced 5 × 10¹⁴ carboxylate groups/cm² in the 25 Å XPS sampling depth. Of these, up to 98% could be converted to the amide. The advancing contact angle data confirmed the acid/base behavior of the functional groups.     

Effects of category prototypes on performance-rating accuracy.

Two studies examined whether the accessibility of performance prototypes influences performance appraisals. Pilot studies revealed students used performance prototypes when rating instructor performance. Study 1 manipulated the accessibility of these prototypes and the time delay of performance ratings. Results showed no effect of the prime on rating error and accuracy; however, discrimination accuracy decreased over time and recognition bias became more conservative. Study 2 manipulated prototype accessibility and type of rating stimuli (videotape vs. vignette). Rating accuracy and recall were higher for vignette than videotape stimuli, and only those participants exposed to the vignette exhibited priming effects. Results supported transfer-appropriate processing and implied that cognitive primes may have a stronger effect on performance ratings based on "paper-people" than videotaped stimuli. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dusts,scale, slags,sludges... Not wastes,but sources of profits

Historically, the steel industry has focused on the need for and the many benefits of recycling steel that is discarded either in its own or in its customers’ manufacturing processes, as well as in recovery and reuse of steel scrap that arises after the product has served its intended purpose. In fact, modern steelmaking relies on the use of recycled iron units for at least half of its production. The other side of the story is the fate of the non-steel by-products (e.g., oxide dusts, sludges, scales, slags, spent refractories and the contained “low grade” energy units that are generated as natural adjuncts to iron and steelmaking processes). These valuable by-products often are classified as “wastes” and are discarded to landfills, at significant cost, although in reality they offer significant potential for cost savings or profit if reintroduced into the industrial arena via well planned programs. Examples of such instances will be presented, including energy credit issues, in the hope of pointing the way for future expansion of benefits from these opportunities. Preparing for a challenge and honor such as the Howe Memorial Lecture, one has to stand in awe of the accomplishments of the predecessor we honor in this forum. He worked in the early days of our industry without the benefits of the many technological improvements he and his successors brought to play as the years went by. John Stubbles, in his Howe Memorial Lecture in 1997,_[1] presented a masterful and entertaining biography of Howe and his very active and prolific life. Perhaps the most telling quotation he attributed to Howe is very pertinent to the topic we will address presently: “Metallurgy lives by profit, not logic,” to which I would like to add a comment that bears on the topic of this lecture from the 1991 Howe lecturer, my friend and mentor Bill Dennis, “Where there is muck, there is money.” There are numerous examples of “one hand washes the other” in this business; that is, of the synergism between needs and capabilities. We will address some of these situations, such as in a new process under development for dezincing of post consumer scrap, and in the use of iron units in by-product oxides and recycling of ladle slags and of spent refractories. Peter J. Koros, the Iron and Steel Society’s 77th Howe Memorial Lecturer (2001), is Principal of Koros Associates, Inc. (Pittsburgh, PA), a consultancy he founded following retirement from the former LTV Steel Company where he worked for nearly 41 years, retiring as Senior Research Consultant. He earned the Bachelor of Science degree in Metallurgical Engineering from Drexel University, and his master’s and doctoral degrees in Metallurgy from the Massachusetts Institute of Technology (MIT). In 1958, he joined Jones and Laughlin Steel (which became LTV Steel Company), where he held positions in research (Director, Process Metallurgy), Technical Services and Quality Control, with most activities focused on steelmaking and related areas. He was responsible for J&L’s development work in injection technology for desulfurization of hot metal and steel, was the inventor of the patented co-injection concept now in use worldwide, and had the lead role in LTV Steel’s programs for degalvanizing scrap and for recovery and utilization of by-product oxides. He led the AISI Opt-In program for degalvanizing scrap and the LTV-USS pilot program for processing “by-product” oxides. Koros has authored more than 75 publications and presentations, and holds eight U.S. patents, the latest issued in 2000. Dr. Koros was elected a Distinguished Member and Fellow of the ISS in 1984 and a Fellow of ASM International in 1988. Other honors include the ISS Distinguished Service Award (1998), ISS Electric Furnace Honorable Mention Citation (1987), International Magnesium Association Design and Applications Award (1978), AISI Gold (1977) and Silver (1969) Medals, ISS Herty (1963), McKune (1963), and Toy (1962) Awards. Koros served on the Technical Advisory Committee of the AISI-DOE Direct Steelmaking Program and its follow-on Waste Oxide Recycling Program. He was chairman of the AISI Task Force on Degalvanizing Steel Scrap and of the Industrial Advisory Panel to the Argonne Lab-MRI Program on Dezincing Steel Scrap. The 2001 Howe Memorial Lecture, titled “Dusts, Scale, Slags, Sludges ... Not Wastes But Sources of Profits,” as well as an invited Keynote Lecture for an International Recycling Conference in Sweden (June 2002, “Iron Units in Search of a Home: New Steel”) were based on the experience from these programs. Koros has been an active member of the ISS Advanced Technology Committee for which he participated in and chaired several symposia, including New Melting Technologies II (October 2002) and the first New Melting Technologies Symposium (1997). He was Director of the ISS 2000 Short Course on Injection Technology, a lecturer in the 2000 ISS/AISI Course on BOF Steelmaking, lead Co-chairman for the Elliott Symposium (1990), and Chairman of the Program Committee for the Fifth International Iron and Steel Congress (1986). Dr. Koros served on the Industrial Advisory Board of MIT’s Materials Processing Center (1995–98) and the AISI’s Iron and Steel Research Subcommittee (1976–86.) He was chairman of the ISS National Science Foundation Advisory Committee, the Advisory Council of the U.S. Bureau of Mines Generic Minerals Technology Center for Pyrometallurgy Research (1983–85), and of the Advisory Board for Carnegie Mellon University’s Center for Iron and Steel Research, for which he served as chairman (1991–1992). Service included participation in the NRC-NAS Alternative Energy and Development Strategy Study (1989–90.) Koros was very active in the creation of the ISS, having served as Chairman of the predecessor TMS Iron and Steel Division in 1972–73 and on the AIME Board of Directors (1974). Professional Society memberships: ISS (elected Distinguished Member and Fellow, Life Member), TMS (Senior or Life Member), ASM International (elected Fellow, Life Member), and AISE.     

Normalization and Deconfliction

In last month’s column we started the correlation process. This early work simply looked at individual pieces of evidence as they might relate to other pieces of evidence. However, there are some potential pitfalls if we stop here. First, digital evidence can be ambiguous. In other words, we can see the same event reported by various sources in various ways. Are we really looking at the same event, or are we looking at different ones? The second issue is that events may be reported in unusual ways leading the analyst to believe that the event occurred multiple times when, in fact, it did not. We need processes to analyze all the events that are reported and to help us to understand the actual data that we are seeing. Fortunately, we actually have two: normalization and deconfliction. Those two processes will be the topics of this month’s offering.