Association of LTA and SOD Gene Polymorphisms with Cerebral White Matter Hyperintensities in Migraine Patients

White matter hyperintensities (WMHs) in migraine could be related to inflammatory and antioxidant events. The aim of this study is to verify whether migraine patients with WMHs carry a genetic pro-inflammatory/pro-oxidative status. To test this hypothesis, we analyzed lymphotoxin alpha (LTA; rs2071590T and rs2844482G) and superoxide dismutase 1 (SOD1; rs2234694C) and 2 (SOD2; rs4880T) gene polymorphisms (SNPs) in 370 consecutive patients affected by episodic (EM; n = 251) and chronic (CM; n = 119) migraine and in unrelated healthy controls (n = 100). Brain magnetic resonance was available in 183/370 patients. The results obtained show that genotypes and allele frequencies for all tested SNPs did not differ between patients and controls. No association was found between single SNPs or haplotypes and sex, migraine type, cardiovascular risk factors or disorders. Conversely, the LTA rs2071590T (OR = 2.2) and the SOD1 rs2234694C (OR = 4.9) alleles were both associated with WMHs. A four-loci haplotype (TGCT haplotype: rs2071590T/rs2844482G/rs2234694C/rs4880T) was significantly more frequent in migraineurs with WMHs (7 of 38) compared to those without WMHs (4 of 134; OR = 8.7). We may, therefore, conclude by suggesting that that an imbalance between pro-inflammatory/pro-oxidative and antioxidant events in genetically predisposed individuals may influence the development of WMHs.     

Hide tanning with modified natural tannins

Tannin from “Acacia Mearnsii” usually called Mimosa, is largely employed in vegetal tanning of hide even if the quality of the leather is poorer than that obtained using chromium as tanning agents. However, taking into account the natural resources of this product and its reduced environmental impact, mimosa tannin has been modified to obtain leather having improved properties. Tannin was modified using formaldehyde, urea, a sulfonic acid and a sulfiting agent: The new products show a higher molecular weight than mimosa tannin but maintain a good solubility in water. Modified tannins were characterized through physicochemical and technological tests and evaluated as tanning agents. The properties of tanned leathers obtained using the new tannin products and mimosa were compared. Some of the polymers containing phenolsulfonic acid are good tannin agents, especially those with a suitable molecular weight. The technological and sensorial properties of the leather obtained using modified tannins (distension and strength of grain, tensile strength, elongation, and tear load) are better than those obtained using mimosa when an appropriate ratio of the reagents were employed. At the same time the feeling of the tanned leather was improved and the final products show fullness, elasticity, fluency, reactivity, and a thin and fine grain. Some of the tannins modified with naphtalensulfonic acid show poor tanning properties but good penetration in the leather suggesting their use as auxiliary sintans in the pretanning process. A simple procedure to prepare these modified tanning agents in the course of the tannin extraction is suggested. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

A new approach to study the influence of the weld bead morphology on the fatigue behaviour of Ti–6Al–4V laser beam-welded butt joints

Ti–6Al–4V is an alloy increasingly used in aeronautics due to its high mechanical properties coupled with lightness. An effective technology used to manufacture titanium components with a reduced buy-to-fly ratio is laser beam welding. Previous studies showed that the key factor that rules the mechanical properties and the fatigue life of the joint is its morphology. The aims of this paper were to investigate the influence of the geometrical features of the joints (height of the top and root reinforcement, depth and radius of the underfill, and the valley–valley underfill distance) on their mechanical properties and also to conduct a finite element (FE) analysis on the real geometry of the welded joints. Ti–6Al–4V rolled sheets 3.2 mm thick were welded in butt joint configuration using a laser source and their performance was studied in terms of weld morphology, microstructure, Vickers microhardness and fatigue life. A full factorial plan, designed varying the welding speed and laser power, was carried out. The real geometry and then the joint morphology were studied through an innovative approach: for each specimen, both the total weld face and the total root surface were acquired using a confocal microscope. Finally, through these acquisitions, the clouds of points of the scanned surfaces were used in order to carry out a FE analysis capable of providing a stress concentration factor, K _t , value for each detected joint. The main results are the realization of a reliable FE model by an experimental agreement and the relationship found amongst the fatigue performances and some noticeable metallurgical and geometrical features, such as the underfill depth and the aspect ratio defined as the ratio between the maximum height of the joint and the valley–valley underfill distance.     

Experimental evaluation of dynamic resource orchestration in multi-layer (packet over flexi-grid optical) networks

Network services in 5G will be rolled out as pools of virtual network functions (VNFs) exploiting the advantages of both software-defined networking and network function virtualization. In this context, 5G network services are envisaged as ordered sequences of VNFs resulting in the so-called VNF Forwarding Graphs (VNFFGs). Such VNFs can be allocated over a number of distributed but interconnected data centers (DCs). In this work, a cloud/network orchestrator is discussed to dynamically process and accommodate VNFFG requests over a pool of DCs interconnected by a multi-layer (packet/flexi-grid optical) transport network infrastructure. Two different cloud and network resource allocation algorithms are proposed aiming at: (1) minimizing the distance between the selected DCs and (2) minimizing the load (i.e., consumed cloud resources) of the chosen DCs. In the performance evaluation, the proposed algorithms are experimentally validated and compared on the CTTC ADRENALINE testbed.

     

Benefits of ESA Gravity-Related Hands-on Programmes for University Students’ Careers

The Education Office of the European Space Agency (ESA) offers university students, from ESA Member and Cooperating States, the opportunity to perform investigations in physical sciences, life sciences, and technology, under different gravity conditions through three educational programmes. The “Fly Your Thesis!” (FYT) programme makes use of parabolic flights and the “Drop Your Thesis!” (DYT) programme utilizes a drop tower as microgravity carriers, while the “Spin Your Thesis!” (SYT) programme uses a large centrifuge to create hypergravity. To date, more than hundred university students had the chance to participate in the design, development, and performance of one or more experiments during dedicated campaigns. In the following paper, we examine demographics of past participants of the ESA Education Office gravity-related opportunities over the past seven years and evaluate the benefits of these educational programmes for the participants’ studies and careers. Student teams that participated in one of the programmes between 2009 and 2013 were contacted to fill in a questionnaire. The feedback from the students demonstrate significant benefits extending far beyond the primary educational objectives of these programmes.     

Surface Instability and Chemical Reactivity of ZrSiS and ZrSiSe Nodal‐Line Semimetals

Materials exhibiting nodal‐line fermions promise superb impact on technology for the prospect of dissipationless spintronic devices. Among nodal‐line semimetals, the ZrSiX (X = S, Se, Te) class is the most suitable candidate for such applications. However, the surface chemical reactivity of ZrSiS and ZrSiSe has not been explored yet. Here, by combining different surface‐science tools and density functional theory, it is demonstrated that the formation of ZrSiS and ZrSiSe surfaces by cleavage is accompanied by the washing up of the exotic topological bands, giving rise to the nodal line. Moreover, while the ZrSiS has a termination layer with both Zr and S atoms, in the ZrSiSe surface, reconstruction occurs with the appearance of Si surface atoms, which is particularly prone to oxidation. It is demonstrated that the chemical activity of ZrSiX compounds is mostly determined by the interaction of the Si layer with the ZrX sublayer. A suitable encapsulation for ZrSiX should not only preserve their surfaces from interaction with oxidative species, but also provide a saturation of dangling bonds with minimal distortion of the surface.     

Conceptual and content-based annotation of (multimedia) documents

This paper focuses on the techniques used in an NKRL environment (NKRL = Narrative Knowledge Representation Language) to deal with a general problem affecting the so-called “semantic/conceptual annotations” techniques. These last, mainly ontology-based, aim at “annotating” multimedia documents by representing, in some way, the “inner meaning/deep content” of these documents. For documents of sufficient size, the content modeling operations are separately executed on ‘significant fragments’ of the documents, e.g., “sentences” for natural language texts or “segments” (minimal units for story advancement) in a video context. The general problem above concerns then the possibility of collecting all the partial conceptual representations into a global one. This integration operation must, moreover, be carried out in such a way that the meaning of the full document could go beyond the simple addition of the ‘meanings’ conveyed by the single fragments. In this context, NKRL makes use of second order knowledge representation structures, “completive construction” and “binding occurrences”, for collecting within the conceptual annotation of a whole “narrative” the basic building blocks corresponding to the representation of its composing elementary events. These solutions, of a quite general nature, are discussed in some depth in this paper. This last includes also a short “state of the art” in the annotation domain and some comparisons with the different methodologies proposed in the past for solving the above ‘integration’ problem.     

Predicting Peak Flows in Real Time through Event Based Hydrologic Modeling for a Trans-Boundary River Catchment

Investigating the hydrological response of an area to adverse climate changes and extreme rainfall events is crucial for managing land and water resources and mitigating the natural hazards like floods. Limited availability of the in situ data, especially in case of Transboundary Rivers, further highlights the need to develop and evaluate decision support systems which may predict the flows in real time using open source rainfall data. This paper presents the study conducted in Chenab River catchment, Pakistan, to develop and evaluate a hydrologic model using HEC-HMS for predicting flows based on TRMM rainfall data. The catchment was analyzed for hydro-morphological properties using SRTM DEM in HEC-GeoHMS. To rely on open source data as much as possible, digital soil map of the world developed by FAO and global land cover map developed by European Space Agency were utilized to compute Curve Number grid data for the catchment. These preliminary data analyses were employed to set initial values of different parameters to be used for model calibration. The model was calibrated for five rainfall events occurred in the rainy seasons of 2006, 2010 and 2013. The calibrated model was then validated for four other rainfall events of similar type in the same years. Consistency in simulated and observed flows was found with percent difference in volume ranging from ?6.17 % to 5.47 % and percent difference in peak flows to be in the range of 6.96 % to 7.28 %. Values of Nash-Sutcliffe Efficiency were ranging from 0.299 to 0.909 with an average value of 0.586 for all flow events. The model was found well capable of capturing the hydrologic response of the catchment due to rainfall events and can be helpful in providing alerts of peak flows in real time based on real time/forecasted rainfall data.     

A black box method for solving the complex exponentials approximation problem

A common problem, arising in many different applied contexts, consists in estimating the number of exponentially damped sinusoids whose weighted sum best fits a finite set of noisy data and in estimating their parameters. Many different methods exist to this purpose. The best of them are based on approximate Maximum Likelihood estimators, assuming to know the number of damped sinusoids, which can then be estimated by an order selection procedure. As the problem can be severely ill posed, a stochastic perturbation method is proposed which provides better results than Maximum Likelihood based methods when the signal-to-noise ratio is low. The method depends on some hyperparameters which turn out to be essentially independent of the application. Therefore they can be fixed once and for all, giving rise to a black box method.