Marie Ménard apples with high polyphenol content and a low‐fat diet reduce 1,2‐dimethylhydrazine‐induced colon carcinogenesis in rats: Effects on inflammation and apoptosis

Inflammation may increase cancer risk, therefore, we studied whether polyphenol‐rich Marie Ménard (MM) apples with reported anti‐inflammatory activity prevent 1,2‐dimethylhydrazine (DMH)‐induced colon carcinogenesis in rats and, likewise whether high‐fat (HF) diet promoting carcinogenesis, may affect inflammation. DMH‐induced rats were fed for 15 weeks with: an HF diet (23% corn oil w/w); an HF diet containing 7.6% w/w lyophilized MM (apple diet (AD)); a low‐fat (LF) diet and an HF diet containing piroxicam (PXC) (0.01% w/w) as control. Mucin depleted foci (MDF), precancerous lesions in the colon, were dramatically reduced in the AD, LF, and PXC groups compared with the HF. Peritoneal macrophage activation, an index of systemic inflammation, was significantly decreased in the AD, LF, and PXC groups. TNF‐α, iNOS, IL‐1β, IL‐6 m‐RNA expression in the colon, as well as CD68 cells and plasmatic PGE2 were lower in the AD, but not in the LF group. Apoptosis in the MDF of both the AD and LF‐fed rats was significantly higher than in HF rats. In conclusion, AD has a strong chemopreventive effect, reducing inflammation, and increasing apoptosis, while the chemopreventive effect of the LF diet seems mediated mainly by increased apoptosis in MDF.     

Detection of vesicoureteral reflux using microwave radiometry-system characterization with tissue phantoms

Microwave (MW) radiometry is proposed for passive monitoring of kidney temperature to detect vesicoureteral reflux (VUR) of urine that is externally heated by a MW hyperthermia device and thereafter reflows from the bladder to kidneys during reflux. Here, we characterize in tissue-mimicking phantoms the performance of a 1.375 GHz radiometry system connected to an electromagnetically (EM) shielded microstrip log spiral antenna optimized for VUR detection. Phantom EM properties are characterized using a coaxial dielectric probe and network analyzer (NA). Power reflection and receive patterns of the antenna are measured in layered tissue phantom. Receiver spectral measurements are used to assess EM shielding provided by a metal cup surrounding the antenna. Radiometer and fiberoptic temperature data are recorded for varying volumes (10-30 mL) and temperaturesg (40-46°C) of the urine phantom at 35 mm depth surrounded by 36.5°C muscle phantom. Directional receive pattern with about 5% power spectral density at 35 mm target depth and better than -10 dB return loss from tissue load are measured for the antenna. Antenna measurements demonstrate no deterioration in power reception and effective EM shielding in the presence of the metal cup. Radiometry power measurements are in excellent agreement with the temperature of the kidney phantom. Laboratory testing of the radiometry system in temperature-controlled phantoms supports the feasibility of passive kidney thermometry for VUR detection.     

A 1.0-mW, 71-dB SNDR,fourth-order ΣΔ interface circuit for MEMS microphones

In this paper an integrated interface circuit for condenser MEMS microphones is presented. It consists of an input buffer followed by a multi-bit (12-levels), analog, second-order ΣΔ modulator and a fully-digital, single-bit, fourth-order ΣΔ modulator, thus providing a single-bit output signal with fourth order noise shaping, compatible with standard audio chipsets. The circuit, supplied with 3.3 V, exhibits a current consumption of 215 μA for the analog part and 95 μA for the digital part. The measured signal-to-noise and distortion ratio (SNDR) is 71 dB, with an input signal amplitude as large as −1.8 dB with respect to full-scale, obtained thanks to the use of a feed-forward architecture in the analog ΣΔ modulator, which relaxes the voltage swing requirements of the operational amplifiers. The test chip, fabricated in a 0.35-μm CMOS process, occupies an area of 3 mm², including pads.     

Analysis of the energy efficiency of solar aided biomass gasification for pure hydrogen production

This paper presents a simulative analysis of the energy efficiency of solar aided biomass gasification for pure hydrogen production. Solar heat has been considered as available at 250 °C in three gasification processes: i) gasification reactor followed by two water gas shift reactors and a pressure swing adsorber; ii) gasification reactor followed by an integrated membrane water gas shift reactor; iii) supercritical gasification reactor followed by two flash separators and a pressure swing adsorber.     

Prediction of contact maps with neural networks and correlated mutations

Contact maps of proteins are predicted with neural network-basedmethods, using as input codings of increasing complexity includingevolutionary information, sequence conservation, correlatedmutations and predicted secondary structures. Neural networksare trained on a data set comprising the contact maps of 173non-homologous proteins as computed from their well resolvedthree-dimensional structures. Proteins are selected from theProtein Data Bank database provided that they align with atleast 15 similar sequences in the corresponding families. Thepredictors are trained to learn the association rules betweenthe covalent structure of each protein and its contact map witha standard back propagation algorithm and tested on the sameprotein set with a cross-validation procedure. Our results indicatethat the method can assign protein contacts with an averageaccuracy of 0.21 and with an improvement over a random predictorof a factor >6, which is higher than that previously obtainedwith methods only based either on neural networks or on correlatedmutations. Furthermore, filtering the network outputs with aprocedure based on the residue coordination numbers, the accuracyof predictions increases up to 0.25 for all the proteins, withan 8-fold deviation from a random predictor. These scores arethe highest reported so far for predicting protein contact maps.     

Two Dimensional Josephson Junction Arrays

Two dimensional Josephson junction arrays (JJAs) offer theopportunity to study a variety of basic physical concepts. Thepresent review focuses on recent experimental work on thedynamics of JJAs, as characterized by ac conductancemeasurements. The review starts with a discussion of basicphysics necessary to describe JJAs. Some experimentalissues, array fabrication and measurement techniques areconsidered next. In a perpendicular magnetic field, a JJA isan experimental realization of the frustrated XY model, withthe frustration parameter f, corresponding to the number offlux quanta in a unit cell of the array, adjusted by themagnetic field. It is thereby possible to investigate thenature of the ground states at arbitrary frustrations. Phasetransitions are the next topic: the vortex unbindingtransition is observed at integer f-values, while, if thejunction coupling energies are appropriately varied across thearray, at half-integer f-values the Ising transition,associated with chiral symmetry breaking, may be observed.Some aspects of vortex dynamics, a subject which is not yetcompletely understood, are then considered. Under certainconditions there is virtually no pinning in JJAs, they aretherefore ideally suited for the study of vortex dynamics. Thenext topic of this review is concerned with the influence ofdisorder on the ground states and on the phase transitions inJJAs. Site percolation in JJAs has provided some insightsinto the physics of disordered systems and allowed to verifysome theoretical predictions on percolation in two dimensions.A quick look at JJAs in the underdamped regime concludesthis review.     

Origin of the monochromatic photoemission peak in diamondoid monolayers

Recent photoemission experiments have discovered a highly monochromatized secondary electron peak emitted from diamondoid self-assembled monolayers on metal substrates. New experimental data and simulation results are presented to show that a combination of negative electron affinity and strong electron-phonon scattering is responsible for this behavior. The simulation results are generated using a simple Monte Carlo transport algorithm. The simulated spectra recreate the main spectral features of the measured ones.     

Atomic force microscopy wear characterization of biomedical polymer coatings

Atomic force microscopy (AFM) has become established as a powerful and versatile tool for investigating local mechanical properties. In addition, through the AFM tip–sample interaction, it has become possible to study the effects of perturbations and modifications to the surface of soft samples, such as polymers. The accurate knowledge of their response to continuous AFM scanning could help to design new materials having desirable mechanical properties. In this paper, we present the results obtained by applying a new methodology to investigate wear properties on two different type of polymer, poly(methyl‐methacrylate) and poly(l ‐lactic acid). These polymers have been widely employed in biomedical applications and have recently been considered as good candidates for coronary metallic stent coatings. Copyright © 2006 John Wiley & Sons, Ltd.     

Relevance of air conditioning for 222Radon concentration in shops of the Savona Province, Italy

Radon (222Rn) concentration was evaluated in shops of the Savona Province, Italy, between summer 2002 and winter 2002-2003. The main characteristics of each shops were recorded through a questionnaire investigating the ventilation rate and factors related to 222Rn precursors in the soil and the construction materials. The main variables that were related to radon concentration were the following: age of the building, level of the shop above ground, season of the year, wind exposure, active windows, and type of heating system. Shops equipped with individual air heating/conditioning systems exhibited radon concentrations that were three times higher than those of shops heated by centralized furnaces. Our data indicate that the level of pollution in the shops was of medium level, with an expected low impact on the salespersons' health. Only in wintertime, the action level of 200 Bq m(-3) for the confined environment was reached in 10 shops equipped with individual air heating/conditioning systems.