Receptor-mediated endocytosis of nanoparticles of various shapes

Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.     

Fiber optic hot-wire flowmeter based on a metallic coated hybrid long period grating/fiber Bragg grating structure

In this work an all-optical hot-wire flowmeter based on a silver coated fiber combining a long period grating and a fiber Bragg grating (FBG) structure is proposed. Light from a pump laser at 1480 nm propagating down the fiber is coupled by the long period grating into the fiber cladding and is absorbed by the silver coating deposited on the fiber surface over the Bragg grating structure. This absorption acts like a hot wire raising the fiber temperature locally, which is effectively detected by the FBG resonance shift. The temperature increase depends on the flow speed of the surrounding air, which has the effect of cooling the fiber. It is demonstrated that the Bragg wavelength shift can be related to the flow speed. A flow speed resolution of 0.08 m/s is achieved using this new configuration.     

Comparative study of bone mineralization in children and adolescents with familial short stature and a control group

Within the past year there has been a dramatic increase in the number of molecular epidemiologic studies reported in the literature, particularly those evaluating gene-gene and gene-environment interactions. Molecular epidemiologic studies have become more sophisticated owing to collaborations between laboratory scientists and epidemiologists, and because these studies are now conducted on well-characterized populations with appropriate study design. Although there continue to be inconsistencies across some studies, it is clear that the evaluation of gene-gene and gene-environment interactions can delineate portions of the population who are particularly sensitive to certain carcinogenic exposures, based on polymorphisms in genes involved in preventing and controlling carcinogenesis. Identification of these subsets of susceptible individuals can result in the design of preventive strategies targeting the most "at risk" populations.     

Probability of Pressure Deficit in On-Demand Branched Networks and Incorporation into Design Decisions

This technical paper presents analytical expressions to estimate the probability function of head losses in any path of an on-demand branched irrigation network. They are developed for estimating the probability of pressure deficit of a given magnitude at any hydrant. They are also useful for examining the probability of a power deficit at a pumping station designed to guarantee service to a hydrant, as well as the head characteristic curve of the distribution system linked to a definite probability. All this quantified information is useful for decision making on network design and performance. The probabilities calculated with the developed expressions can be taken as complementary or alternative concepts to Clément’s classical design flow method, which is taken here as a benchmark for comparisons. Illustrative examples of network designs are presented to validate the proposed expressions. The least cost design solutions using Clément’s design flows are compared with design solutions here obtained to get the same probability of pressure deficit at the most unfavorable hydrants. The new solutions are less expensive because the flow constraint can be avoided.     

Identity fusion: The interplay of personal and social identities in extreme group behavior.

The authors propose that when people become fused with a group, their personal and social identities become functionally equivalent. Two hypotheses follow from this proposition. First, activating either personal or social identities of fused persons should increase their willingness to endorse extreme behaviors on behalf of the group. Second, because personal as well as social identities support group-related behaviors of fused persons, the 2 forms of identity may combine synergistically, fostering exceptionally high levels of extreme behavior. Support for these hypotheses came from 5 preliminary studies and 3 experiments. In particular, fused persons were more willing to fight or die for the group than nonfused persons, especially when their personal or social identities had been activated. The authors conclude that among fused persons, both the personal and social self may energize and direct group-related behavior. Implications for related theoretical approaches and for conceptualizing the relationship between personal identities, social identities, and group processes are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Capacitive depression sensor for microfluidic pneumatic networks

This paper reports a capacitive depression sensor intended to make measurements in-line in microfluidics pneumatic networks which works with negative pressures in the order of hundreds of millibars. The principle of operation of the sensor is neither thermal nor magnetic, but purely mechanical, and does not need a servomechanism. The proposed device is composed by two circular membranes linked by a column. This structure presents a particular behavior when exerting negative pressures between the membranes, named negative behavior. The behavior is confirmed prior to fabrication using numerical simulations. The materials used are the negative epoxy photoresist SU-8, printed circuit board (PCB) and sputtered gold. The device has been experimentally tested in the laboratory with successful results, providing an increment of capacitance from 1.7 to 3 pF for applied depressions from 0 to 500 mbar and presenting good agreement with the electromechanical FEM simulations.     

Coupling GIS with Hydrologic and Hydraulic Flood Modelling

Geographic Information Systems (GIS) have been recognised as a powerful means to integrate and analyse data from various sources in the context of comprehensive floodplain management. As part of this comprehensive approach to floodplain management, it is very important to be able to predict the consequences of different scenarios in terms of flooded areas and associated risk. Hydrologic and hydraulic modelling plays a crucial role and there is much to gain in incorporating these modelling capabilities in GIS. This is still a rather complex task and research is being done on the full integration of these models. Interfacing between these models and GIS may be a very efficient way of overcoming the difficulties and getting very good results in terms of engineering practice. This paper presents results based on the use of Intergraph GIS coupled with Idrisi GIS. Using these two systems substantially increased the flexibility of using GIS as a tool for flood studies. A lumped (XSRAIN) and a distributed (OMEGA) hydrologic models were used to simulate flood hydrographs. The well known HEC-2 Hydraulic model was used to compute flooded areas. These models were applied in the Livramento catchment with very good results. The computation of flooded areas for different flood scenarios, and its representation in GIS, can be used in the assessment of affected property and associated damages. This is a very useful GIS-based approach to floodplain management.     

The antimicrobial effect of wine on Listeria innocua in a model stomach system

A model stomach, containing a food matrix and a synthetic gastric fluid, was used to study the bactericidal effect of ingested wine on Listeria innocua. Volumes of wine equivalent to the ingestion of one glass and half a bottle, led, over a period of less than 2 h, to a reduction of 3 and 4 logarithmic cycles of the initial population respectively. The influence of ethanol and organic acids, wine constituents with known antimicrobial properties, was investigated. Ethanol exhibited a higher bactericidal effect than the mixture of the main wine organic acids. When testing the organic acids separately, malic and lactic acids were found to have the strongest effect. The combination of ethanol with the organic acids acted synergistically but to a lesser extent than wine itself. The results suggest that the ingestion of wine during a meal may diminish the quantity of Listeria persisting further in the alimentary tract.