Thermal stability and thermal expansion behavior of FeCoCrNi2Al high entropy alloy

Present work reports the thermal stability and thermal expansion behavior of dual-phase FeCoCrNi₂Al HEA prepared by Mechanical Activated Synthesis and consolidated by hot pressing. The thermal stability of the phases present in FeCoCrNi₂Al HEA has been extensively studied using in-situ high-temperature X-ray diffraction (HT-XRD) in conjunction with dilatometry and differential scanning calorimetry (DSC). The DSC thermogram shows a single endothermic peak at 1430 °C (1703 K) which belongs to the melting point of the alloy. HT-XRD and dilatometry experiments were carried out from room temperature to 1000 °C (1273 K). HT-XRD study has shown that the room temperature FCC + BCC (face-centred cubic + body-centred cubic) phases remains stable up to 1000 °C (1273 K). Although the amount of BCC phase has increased above 800 °C (1073 K), no additional phase formation was observed in HT-XRD. The coefficient of thermal expansion (CTE) curve shows linear increment up to 1000 °C (1273 K) with a slight change in slope beyond 800 °C (1073 K). Theoretical CTE was computed using the lattice parameter of the FCC phase, obtained from HT-XRD, as a function of temperature and compared with experimental CTE. Third-order polynomial equation was fitted to the experimental CTE data and the constants were evaluated which can be used to predict the coefficient of thermal expansion of the alloy.     

Systematic development and optimization of spray-dried Quercetin-HP-β-cyclodextrin microparticles for DPI-based therapy of lung cancer

Journal of Materials Science - Despite the strong anticancer activity, Quercetin (QC) has low aqueous solubility, resulting in poor bioavailability which restricts its pharmacological activity. To...     

Energy efficient reputation mechanism for defending different types of flooding attack

Wireless Networks - Delay tolerant network solves technical challenges in the heterogeneous network that may lack end-to-end connectivity. However, due to the disconnected paths, message delivery...     

Cost and Sub-Epoch Based Stable Energy-Efficient Clustering Algorithm for Heterogeneous Wireless Sensor Networks

Wireless Personal Communications - This paper proposes a cost and sub-epoch based stable energy-efficient clustering (CSSEEC) algorithm for heterogeneous wireless sensor networks. In this paper, we...     

Milk composition traits in Jamunapari goats: Genetic parameters and effect of CSN1S1 gene variants

Milk protein polymorphism was analysed to improve the protein content in milk. The present study characterises the CSN1S1 gene and the effect of allelic combinations on milk composition traits in Jamunapari goats. The allelic variants obtained from sodium dodecyl sulfate polyacrylamide gel electrophoresis and polymerase chain reaction–restriction fragment length polymorphism were confirmed by cloning and sequencing. Genetic parameters were obtained from 518 records from 48 sires and 131 dams. The A, B and F alleles were observed in the population and the protein percentage in milk was significantly (P < 0.01) affected by allelic variants. The frequencies of A, B and F alleles were 0.456, 0.503 and 0.041, respectively. The protein content in milk was highest in the goats with AB genotype followed by AA > BB > BF > AF > FF. The goats with AB genotype had a significantly (P < 0.01) higher protein percentage in milk than goats with BF (t = 5.311, df = 113), AF (t = 8.13, df = 123) and FF (t = 9.55, df = 115) genotypes. The direct heritability for protein percentage was 0.441. Parity and season of birth had significant effects (P < 0.05) on the solids‐not‐fat percentage and lactose concentrations. The CSN1S1 AA, AB and BB genotypes should be selected for higher protein content and to improve milk quality and processing traits in Indian goats.     

Anomalous ferroelectric and magnetic behavior in BPFO-NZFO multiferroic nano-composites

Multiferroic nano-composites (1-x) Bi_.9Pr_.1FeO₃ (BPFO) –x Ni_.5Zn_.5Fe₂O₄ (NZFO) for x?=?0.0, 0.1, 0.2, 0.3 and 1.0 were synthesized by sol-gel auto-combustion method. Detailed investigations were made on the structural, morphological, ferroelectric, magnetic and dielectric properties of these nano-composites. The X-ray Diffraction pattern confirms the co-existence of perovskite BPFO and spinel NZFO phases without any impurity. The average particle size of as prepared BPFO and NZFO nanoparticles is nearly equal to 110?nm and 35?nm respectively which have been confirmed by the XRD and Transmission Electron Microscopy analysis. Structural and surface morphology are studied by Scanning Electron Microscopy. The dielectric properties of the composites are also studied at room temperature. The magnetic hysteresis loop has been studied to know the magnetic response of samples to the applied magnetic field of ±?1?T at room temperature. The saturation and remnant magnetization are found to increase with increase in NZFO weight percentage in the composite. The saturation magnetization values are 8.57?emu/g, 16.71?emu/g, 24.41?emu/g and remnant magnetization values are 0.78?emu/g, 1.23?emu/g, 1.58?emu/g for BPFO-NZFO 1, 2, 3 composite samples respectively. An anomalous ferroelectric behavior of BPFO-NZFO 1 composite sample was observed which can be understand with the help of observed results in dielectric and morphology of the samples. The incorporation of BPFO and NZFO enhances the multiferroic properties in the present composite materials which are quite promising from application point of view.     

Controlling PROTACs with Light

Proteolysis targeting chimeras, PROTACs, are emerging as a powerful strategy for exerting exogenous control over protein levels, allowing small molecules to exploit the ubiquitin–proteasome pathway for targeted protein degradation. This highlight focuses on the fusion of photochemistry with these bifunctional compounds, which has provided a novel pathway for spatiotemporally tuning the activation of PROTACs in the form of their photocaged and photoswitchable versions. Photocaged PROTACs consist of a hindered optolabile group that detaches only upon irradiation at a specific wavelength, releasing the active PROTAC. These modified PROTACs are inactive in the dark. Photoswitchable PROTACs are photoisomerizable molecules with azobenzene linkages that are active in either the cis or trans form and inactive in the other. The isomers interconvert upon irradiation with an appropriate wavelength of light and relax to the thermodynamically stable isomer in the dark or with another wavelength of light. Although photocaged PROTACs only permit activation control for protein degradation, photoswitching PROTACs offer reversible activation and deactivation by using suitable wavelengths of light.