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121.
Konstadinidis G.K. Normoyle K. Samson Wong Bhutani S. Stuimer H. Johnson T. Smith A. Cheung D.Y. Romano F. Shifeng Yu Sung-Hun Oh Melamed V. Narayanan S. Bunsey D. Cong Khieu Wu K.J. Schmitt R. Dumlao A. Sutera M. Jade Chau Lin K.J. Coates W.S. 《Solid-State Circuits, IEEE Journal of》2002,37(11):1461-1469
This third-generation 1.1-GHz 64-bit UltraSPARC microprocessor provides 1-MB on-chip level-2 cache, 4-Gb/s off chip memory bandwidth, and a new 200 MHz JBus interface that supports one to four processors. The 87.5-million transistor chip is implemented in a seven-layer-metal copper 0.13-/spl mu/m CMOS process and dissipates 53 W at 1.3 V and 1.1 GHz. 相似文献
122.
Roberta D’Ambrosio Alessio Aghemo Raffaele De Francesco Maria Grazia Rumi Enrico Galmozzi Stella De Nicola Cristina Cheroni Paul J. Clark Guido Ronchi Pietro Lampertico Massimo Colombo 《International journal of molecular sciences》2014,15(5):7213-7224
The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients.
Materials and Methods
Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as <5% or ≥5%. IL28B was typed by Taqman Single Nucleotide Polymorphism (SNP) genotyping assay. HCV genotype was 1 in 151 (45%), 2 in 99 (30%), 3 in 50 (15%) and 4 in 35 (10%) patients. IL28B genotype was CC in 117 (34%), CT in 166 (49%) and TT in 52 (15%). At univariate analysis, the IL28B CC genotype was associated with severe portal inflammation in HCV-1 patients (CC vs. CT/TT: 86% vs. 63%, p = 0.005), severe lobular inflammation in HCV-2 patients (CC vs. CT/TT: 44% vs. 23%, p = 0.03), and less fatty infiltration in HCV-1 patients (CC vs. CT/TT: 72% vs. 51%, p = 0.02). Despite the lack of any association between IL28B and fibrosis stage, in HCV-3 patients IL28B CC correlated with METAVIR F3–F4 (CC vs. CT/TT: 74% vs. 26%, p = 0.05). At multivariate analysis, the genotype CC remained associated with severe portal inflammation in HCV-1, only (Odds Ratio (OR): 95% Confidence Interval (CI): 3.24 (1.23–8.51)). IL28B genotype is associated with the histological features of chronic hepatitis C in a HCV genotype dependent manner, with CC genotype being independently associated with severe portal inflammation. 相似文献123.
Benedetto Bozzini Amilcare Barca Francesco Bogani Marco Boniardi Paolo Carlino Claudio Mele Tiziano Verri Alessandro Romano 《Journal of materials science. Materials in medicine》2014,25(6):1425-1434
In this paper we describe the one-pot fabrication of hydroxyapatite (HA)-heparin composites by electrodeposition onto Ti substrates and their characterisation in terms of structure, morphology, heparin content and bioactivity. HA coatings are well known and widely applied osteointegration enhancers, but post-implant healing rate in dental applications is still suboptimal: e.g. coagulation control plays a key role and the incorporation of an anticoagulant is considered a highly desirable option. In this study, we have developed an improved, simple and robust growth procedure for single-phase, pure HA-heparin films of thickness 1/3 μm. HA-heparin, forming nanowires, has the ideal morphology for bone mineralisation. Staining assays revealed homogeneous incorporation of sizable amounts of heparin in the composite films. The bioactivities of the HA and HA-heparin coatings on Ti were compared by HeLa cell proliferation/viability tests and found to be enhanced by the presence of the anticoagulant. 相似文献
124.
Tjstil Vlaar Lisa Bensch Jasper Kraakman Christophe M. L. VandeVelde Bert U. W. Maes Romano V. A. Orru Eelco Ruijter 《Advanced Synthesis \u0026amp; Catalysis》2014,356(6):1205-1209
We report the palladium(II)‐catalyzed aerobic oxidative coupling of isocyanides with various (2‐aminophenyl)azoles using air as the stoichiometric oxidant. A diverse range of medicinally valuable azolo[c]quinazolines was obtained by this new approach.
125.
Enrico Binetti Marinella Striccoli Teresa Sibillano Cinzia Giannini Rosaria Brescia Andrea Falqui Roberto Comparelli Michela Corricelli Raffaele Tommasi Angela Agostiano M Lucia Curri 《Science and Technology of Advanced Materials》2015,16(5)
Colloidal semiconductor nanocrystals, with intense and sharp-line emission between red and near-infrared spectral regions, are of great interest for optoelectronic and bio-imaging applications. The growth of an inorganic passivation layer on nanocrystal surfaces is a common strategy to improve their chemical and optical stability and their photoluminescence quantum yield. In particular, cation exchange is a suitable approach for shell growth at the expense of the nanocrystal core size. Here, the cation exchange process is used to promote the formation of a CdS passivation layer on the surface of very small PbS nanocrystals (2.3 nm in diameter), blue shifting their optical spectra and yielding luminescent and stable nanostructures emitting in the range of 700–850 nm. Structural, morphological and compositional investigation confirms the nanocrystal size contraction after the cation-exchange process, while the PbS rock-salt crystalline phase is retained. Absorption and photoluminescence spectroscopy demonstrate the growth of a passivation layer with a decrease of the PbS core size, as inferred by the blue-shift of the excitonic peaks. The surface passivation strongly increases the photoluminescence intensity and the excited state lifetime. In addition, the nanocrystals reveal increased stability against oxidation over time. Thanks to their absorption and emission spectral range and the slow recombination dynamics, such highly luminescent nano-objects can find interesting applications in sensitized photovoltaic cells and light-emitting devices. 相似文献
126.
Sassolas B Benoît Q Flaminio R Forest D Franc J Galimberti M Lacoudre A Michel C Montorio JL Morgado N Pinard L 《Applied optics》2011,50(13):1894-1899
Gravitational-wave detectors such as Virgo and the laser interferometric gravitational-wave observatory (LIGO) use a long-baseline Michelson interferometer with Fabry-Perot cavities in the arms to search for gravitational waves. The symmetry between the two Fabry-Perot cavities is crucial to reduce the interferometer's sensitivity to the laser amplitude and frequency noise. To this purpose, the transmittance of the mirrors in both cavities should be as close as possible. This paper describes the realization and the characterization of the first twin large low-loss mirrors with transmissions differing by less than 0.01%. 相似文献
127.
Francesco Colella Guillermo Rein Romano Borchiellini Jose L. Torero 《Fire Technology》2011,47(1):221-253
This paper applies a novel and fast modelling approach to simulate tunnel ventilation flows during fires. The complexity and
high cost of full CFD models and the inaccuracies of simplistic zone or analytical models are avoided by efficiently combining
mono-dimensional (1D) and CFD (3D) modelling techniques. A simple 1D network approach is used to model tunnel regions where
the flow is fully developed (far field), and a detailed CFD representation is used where flow conditions require 3D resolution (near field). This multi-scale method has previously been applied to simulate tunnel ventilation systems including jet fans, vertical
shafts and portals (Colella et al., Build Environ 44(12): 2357–2367, 2009) and it is applied here to include the effect of
fire. Both direct and indirect coupling strategies are investigated and compared for steady state conditions. The methodology
has been applied to a modern tunnel of 7 m diameter and 1.2 km in length. Different fire scenarios ranging from 10 MW to 100 MW
are investigated with a variable number of operating jet fans. Comparison of cold flow cases with fire cases provides a quantification
of the fire throttling effect, which is seen to be large and to reduce the flow by more than 30% for a 100 MW fire. Emphasis
has been given to the discussion of the different coupling procedures and the control of the numerical error. Compared to
the full CFD solution, the maximum flow field error can be reduced to less than few percents, but providing a reduction of
two orders of magnitude in computational time. The much lower computational cost is of great engineering value, especially
for parametric and sensitivity studies required in the design or assessment of ventilation and fire safety systems. 相似文献
128.
Raffaele Landolfo Lucrezia Cascini Francesco Portioli 《Frontiers of Architecture and Civil Engineering in China》2011,5(3):304-314
Nowadays, the construction sector is more and more oriented toward the promotion of sustainability in all its activities.
The goal to achieve is the optimization of performances, over the whole life-cycle, with respect to environmental, economic
and social requirements. According to the latest advances, the concept of sustainability applied to constructions covers a
number of branches such as life-cycle costing, ecology, durability and even structural design. Several procedures and design
tools have been implemented in the framework of international research. Indeed the current trend in civil engineering research
is moving towards life-time engineering, with the aim to implement integrated methodologies to consider as a whole all the
sustainability requirements according to time-dependent multi-performance-based design approaches. Following a general introduction
of the concept of sustainability applied to constructions, this paper presents an overview of life-time engineering methodologies
according to the current state-of-the-art. In particular the methods currently received by International Standards are discussed.
A special focus is devoted to the durability design of metal structures with respect to the degradation phenomena able to
impair the structural capacity over time. Finally a proposal towards an integrated approach to life-time engineering design
of steel structures and needs for further advances are presented. 相似文献
129.
PR Romano F Zhang SL Tan MT Garcia-Barrio MG Katze TE Dever AG Hinnebusch 《Canadian Metallurgical Quarterly》1998,18(12):7304-7316
The human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein synthesis by phosphorylating translation initiation factor 2alpha (eIF2alpha). Vaccinia virus E3L encodes a dsRNA binding protein that inhibits PKR in virus-infected cells, presumably by sequestering dsRNA activators. Expression of PKR in Saccharomyces cerevisiae inhibits protein synthesis by phosphorylation of eIF2alpha, dependent on its two dsRNA binding motifs (DRBMs). We found that expression of E3 in yeast overcomes the lethal effect of PKR in a manner requiring key residues (Lys-167 and Arg-168) needed for dsRNA binding by E3 in vitro. Unexpectedly, the N-terminal half of E3, and residue Trp-66 in particular, also is required for anti-PKR function. Because the E3 N-terminal region does not contribute to dsRNA binding in vitro, it appears that sequestering dsRNA is not the sole function of E3 needed for inhibition of PKR. This conclusion was supported by the fact that E3 activity was antagonized, not augmented, by overexpressing the catalytically defective PKR-K296R protein containing functional DRBMs. Coimmunoprecipitation experiments showed that a majority of PKR in yeast extracts was in a complex with E3, whose formation was completely dependent on the dsRNA binding activity of E3 and enhanced by the N-terminal half of E3. In yeast two-hybrid assays and in vitro protein binding experiments, segments of E3 and PKR containing their respective DRBMs interacted in a manner requiring E3 residues Lys-167 and Arg-168. We also detected interactions between PKR and the N-terminal half of E3 in the yeast two-hybrid and lambda repressor dimerization assays. In the latter case, the N-terminal half of E3 interacted with the kinase domain of PKR, dependent on E3 residue Trp-66. We propose that effective inhibition of PKR in yeast requires formation of an E3-PKR-dsRNA complex, in which the N-terminal half of E3 physically interacts with the protein kinase domain of PKR. 相似文献
130.
M Amichetti G Fellin A Bolner L Busana G Pani M Romano M Scillieri S Maluta 《Canadian Metallurgical Quarterly》1994,80(2):141-145
AIMS AND BACKGROUND: Pure testicular seminoma has historically been treated with post-orchidectomy radiation therapy with excellent results. Recently, several aspects of the treatment of stage I seminoma have been questioned. We assessed long-term results and toxicity of patients with pure testicular seminoma treated at the Department of Radiation Oncology of S. Chiara Hospital, Trento, METHODS: From 1953 to 1987, 102 patients with stage I pure testicular seminoma were given megavoltage irradiation with curative intent. All patients had a minimum follow-up of 3 years (maximum 37 years, median 13 years). They received a mean para-aortic/pelvic dose of 33.07 Gy (range 23.70-45.20 Gy) with different doses and fields reflecting the change in techniques over a long period of time. RESULTS: The cause-specific actuarial survival at 30 years was 99% and crude survival 67%. One patient had an out-field relapse (inguinal) after a few months and was cured with radiotherapy and chemotherapy. Another patient relapsed with widespread metastases and died after 1 year of progressive disease. Early toxycity was mild and the treatment was well tolerated. Late side effects were reported in 8/102 patients. CONCLUSIONS: In our series adjuvant radiation therapy resulted in cure rates corresponding to those reported in the literature. The 30-year actuarial survival of 99% was extremely good and the toxicity of the treatment was mild. Post-orchidectomy radiation to the para-aortic and ipsilateral pelvic nodes is a safe and effective method of preventing recurrences and is currently to be considered the treatment of choice in stage I testicular seminoma. 相似文献