Sex Differences and Individual Differences in Cognitive Performance and Their Relationship to Endogenous Gonadal Hormones and Gonadotropins.

Sexually dimorphic cognitive performance in men (n=42) and women (n=42) was related to testosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and sex hormone binding globulin, measured in 10-ml blood samples collected between 0900 and 1030 and, among women, during the follicular phase of the menstrual cycle. Significant sex differences favored men on spatial tasks (Mental Rotation and Judgment of Line Orientation) and on an inhibition task and favored women on a verbal task (category fluency). However, there were no significant relationships between any of the hormones and cognitive performance, suggesting that there are few, if any, consistent, substantial relationships between endogenous, nonfluctuating levels of gonadal hormones or gonadotropins and these cognitive abilities in men or women. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Designing communication strategies for heterogeneous parallel systems

This paper explores the suitability of the emerging passive star-coupled optical interconnection using wavelength division multiplexing as the system interconnect to provide high bandwidth (Gbits/sec) communication demanded by heterogeneous systems. Several different communication strategies (combinations of communication topologies and protocols) are investigated under a representative master-slave computational model. The interplay between system speed, network speed, task granularity, and degree of parallelism is studied using both analytical modeling and simulations. It is shown that a hierarchical ALOHA-based communication strategy between the master and the slaves, implemented on top of the passive star-coupled network, leads to a considerable reduction in channel contention and provides 50–80% reduction in task completion time for applications with medium to high degrees of coarse grain parallelism. Comparable reduction in channel contention is also shown to be achieved by using tunable acoustooptic filters at master nodes.     

Computing planar swept polygons under translation

A translational sweep is the translating of a polygon, called the generatrix G, around another polygon, called the directrix D, under two conditions: (1) G is always in contact with D; and (2) the interiors of G and D do not intersect. Three classes of translational sweep are studied, including the case in which both G and D are convex; the case in which G is convex, D monotone; and the case in which both are monotone. Efficient algorithms for computing the trajectory and the swept area as well as geometric and computational properties are presented for each class. A notion called the inverse generatrix, which reveals a duality between the trajectory and the swept polygon, is introduced to reduce complexity.     

Inferential Queueing and Speculative Push

Communication latencies within critical sections constitute a major bottleneck in some classes of emerging parallel workloads. In this paper, we argue for the use of two mechanisms to reduce these communication latencies: Inferentially Queued locks (IQLs) and Speculative Push (SP). With IQLs, the processor infers the existence, and limits, of a critical section from the use of synchronization instructions and joins a queue of lock requestors, reducing synchronization delay. The SP mechanism extracts information about program structure by observing IQLs. SP allows the cache controller, responding to a request for a cache line that likely includes a lock variable, to predict the data sets the requestor will modify within the associated critical section. The controller then pushes these lines from its own cache to the target cache, as well as writing them to memory. Overlapping the protected data transfer with that of the lock can substantially reduce the communication latencies within critical sections. By pushing data in exclusive state, the mechanism can collapse a read-modify-write sequences within a critical section into a single local cache access. The write-back to memory allows the receiving cache to ignore the push. Neither mechanism requires any programmer or compiler support nor any instruction set changes. Our experiments demonstrate that IQLs and SP can improve performance of applications employing frequent synchronization.     

Nonlinear<Emphasis Type="Italic">I-V</Emphasis> characteristics study of doped SnO<Subscript>2</Subscript>

When tin oxide is doped with Sb₂O₃ and CoO, it shows highly nonlinear current (I)-voltage (V) characteristics. Addition of CoO leads to creation of oxygen vacancies and helps in sintering of SnO₂. Antimony oxide acts as a donor and increases the conductivity. The results are nearly the same when antimony oxide is replaced by tantalum oxide. The observed nonlinear coefficient, α = 30 and the breakdown voltage is 120 V/mm.     

TiB whisker coating on titanium surfaces by solid-state diffusion: Synthesis,microstructure, and mechanical properties

The study demonstrates the feasibility of synthesizing TiB whiskers on titanium (Ti) surfaces by solid-state diffusion to form a hard and wear-resistant coating. The microstructural and mechanical properties of the TiB coating layer have also been investigated. The TiB coating was formed by the solid-state diffusion of boron (B) from a powder mixture containing amorphous boron, Na₂CO₃ powder, and charcoal (activated) powder. The diffusion process was carried out at various temperatures ranging from 800 °C to 1000 °C for various periods of time ranging from 1 to 24 hours. The amount of Na₂CO₃ in the mixture was also varied. It has been found that pristine and extremely fine TiB whiskers form on the surfaces of titanium, with the whiskers growing more or less normal to the surface. A maximum coating thickness of about 218 μm was observed for the pack diffusion conditions at 850 °C for 24 hours with 15 pct Na₂CO₃. The kinetics of TiB formation was found to follow the growth rates in bulk composites. The X-ray diffraction (XRD) patterns of the coatings revealed the dominant TiB peaks with a very few TiB₂ peaks, with small intensity at higher temperature and time. The surface hardness of the coated layer increased to a Vickers hardness of about 550 kgf/mm² due to the presence of TiB whiskers in the coating. It is shown that pack diffusion of boron in the solid state is a simple and very effective means of generating hard and wear-resistant coatings on titanium.     

The Directed Orienteering Problem

This paper studies vehicle routing problems on asymmetric metrics. Our starting point is the directed k-TSP problem: given an asymmetric metric (V,d), a root r∈V and a target k≤|V|, compute the minimum length tour that contains r and at least k other vertices. We present a polynomial time O(\fraclog² nloglogn·logk)O(\frac{\log^{2} n}{\log\log n}\cdot\log k)-approximation algorithm for this problem. We use this algorithm for directed k-TSP to obtain an O(\fraclog² nloglogn)O(\frac{\log^{2} n}{\log\log n})-approximation algorithm for the directed orienteering problem. This answers positively, the question of poly-logarithmic approximability of directed orienteering, an open problem from Blum et al. (SIAM J. Comput. 37(2):653–670, 2007). The previously best known results were quasi-polynomial time algorithms with approximation guarantees of O(log ² k) for directed k-TSP, and O(log n) for directed orienteering (Chekuri and Pal in IEEE Symposium on Foundations in Computer Science, pp. 245–253, 2005). Using the algorithm for directed orienteering within the framework of Blum et al. (SIAM J. Comput. 37(2):653–670, 2007) and Bansal et al. (ACM Symposium on Theory of Computing, pp. 166–174, 2004), we also obtain poly-logarithmic approximation algorithms for the directed versions of discounted-reward TSP and vehicle routing problem with time-windows.     

Graph structure in the Web

The study of the Web as a graph is not only fascinating in its own right, but also yields valuable insight into Web algorithms for crawling, searching and community discovery, and the sociological phenomena which characterize its evolution. We report on experiments on local and global properties of the Web graph using two AltaVista crawls each with over 200 million pages and 1.5 billion links. Our study indicates that the macroscopic structure of the Web is considerably more intricate than suggested by earlier experiments on a smaller scale.     

The RAGE/DIAPH1 Signaling Axis & Implications for the Pathogenesis of Diabetic Complications

Increasing evidence links the RAGE (receptor for advanced glycation end products)/DIAPH1 (Diaphanous 1) signaling axis to the pathogenesis of diabetic complications. RAGE is a multi-ligand receptor and through these ligand–receptor interactions, extensive maladaptive effects are exerted on cell types and tissues targeted for dysfunction in hyperglycemia observed in both type 1 and type 2 diabetes. Recent evidence indicates that RAGE ligands, acting as damage-associated molecular patterns molecules, or DAMPs, through RAGE may impact interferon signaling pathways, specifically through upregulation of IRF7 (interferon regulatory factor 7), thereby heralding and evoking pro-inflammatory effects on vulnerable tissues. Although successful targeting of RAGE in the clinical milieu has, to date, not been met with success, recent approaches to target RAGE intracellular signaling may hold promise to fill this critical gap. This review focuses on recent examples of highlights and updates to the pathobiology of RAGE and DIAPH1 in diabetic complications.