Microstructure and mechanical properties of the superalloy ATI Allvac 718Plus™

ATI Allvac^® 718Plus™ is a novel nickel-based superalloy, which was designed for heavy-duty applications in aerospace turbines. In the present study the high-resolution investigation techniques, atom probe tomography, electron microscopy and in situ high-temperature small-angle neutron scattering were used for a comprehensive microstructural characterization. The alloy contains nanometer-sized spherical γ′ phase precipitates (Ni₃(Al,Ti)) and plate-shaped δ phase precipitates (Ni₃Nb) of micrometer size. The precipitation kinetics of the γ′ phase can be described by a classical model for coarsening. The precipitation strongly influences the mechanical properties and is of high scientific and technological interest.     

Prediction of capillary tubes with alternative refrigerants to CFC‐502

A numerical model is presented in this paper, for predicting capillary tube performance using new alternative refrigerants to CFC‐502. The model has been established after the fluid flow conservation equations written for a homogeneous azeotropic refrigerant fluid flow under saturated, sub‐cooled and two‐phase conditions. The study was limited to the following azeotropic mixtures; R‐507, R‐404A, and quaternary mixture (R32/R125/R134a/R143a). Numerical results showed that the proposed model in question fairly simulated our experimental data and fairly predicted the capillary tube behaviour under different conditions. The results also indicated that a system using R‐507 would experience smaller pressure drop across the capillary compared to the other alternatives under question. Copyright © 2001 John Wiley & Sons, Ltd.     

A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, β-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.     

Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery

Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.