The dynamic influence of genetic variation on the susceptibility of sheep to gastrointestinal nematode infection.

The interaction between sheep and the nematode Teladorsagia circumcincta is one of the best understood of all host-parasite interactions. Following infection, there is considerable variation among lambs in the number of nematode eggs produced, the number of early fourth-stage larvae and the number of adult worms in the mucosa. These traits have a high variance to mean ratio (i.e. they are overdispersed or aggregated among hosts), they are skewed and approximately negative binomially distributed. The sources of overdispersion are differences among lambs in the ingestion of infective larvae and the immune response. Both forces can produce aggregation but their relative importance is unknown. The key components of variation can be identified by variance analysis. The sum of the average effects of polymorphic genes is known as additive genetic variation and this increases essentially from zero at one month of age to quite high values at six months of age. The major mechanism underlying genetic variation appears to be the differences among individuals in immune responses. Two of the major sources of variation in immune responses are differences in antigen recognition and differences in the type of cytokines produced. Genes that influence both these sources of variation are associated with differences in resistance to nematode infection. Therefore, much of the heterogeneity among animals in parasite transmission appears to be due to genetic variation in immune responsiveness.     

The rise of qualitative research in psychology.

A study is presented on the rise of qualitative research in psychology over the 20th century. The incidence of qualitative research as indicated by several search terms (i.e., "qualitative research," "grounded theory," "discourse analy*," "empirical phenomenological," and "phenomenological psychology") was traced through the PsycINFO and Dissertation Abstracts International databases. It was found that, with the exception of the search terms having to do with phenomenology, records containing these search terms were basically non-existent until the 1980s, when there was a sharp rise that intensified in the 1990s. The PsycINFO records were sorted according to (1) whether they came from psychology or other social and health science disciplines; (2) region of origin; (3) the types of document to which they referred; and (4) whether they focused on the methodology or the application of qualitative research. A number of interesting differences emerged from this comparative analysis. Implications of the findings for the supposition that a paradigm shift may be underway are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Can wear in total hip arthroplasties be assessed from radiographs?

The validity of wear measurements from total-hip radiographs was assessed using a wear simulator which consisted of a total hip prosthesis mounted on a Plexiglas orientation jig. Wear was mesured by a micrometer device and uni- and duoradiographic methods of wear measurement were used with a variety of acetabular cup orientations. In the initial calibration studies the duoradiographic technique proved to be more accurate. The source of the inaccuracies of the uniradiographic method was determined analytically by means of a geometrical model. Forty-inch or 72' source-to-object film-distances provided similar accuracy and the errors in wear measurement varied from --0.1 +/- 0.4 mm (2 S.D.) to 0 +/- 0.9 mm for wear magnitudes of 1 and 5 mm respectively, regardless of cup position. In subsequent calibration studies the previous radiographs were compiled to represent seven hypothetical patients at various stages of follow-up whose prostheses exhibited between 1 and 5 mm wear. Clinicians assessed the degree of wear, using both the uni- and duoradiographic techniques, under supervision but unaware of the true position and orientation of the wear track. The resulting errors were of the same order as the wear magnitudes being measured. The location of the measurements on the radiographs was then restricted to approximately the true wear axis but again the errors were so large that it was still impossible to make any valid wear assessments. The calibration runs were therefore terminated at this point and it was concluded that wear measurements could not be made from clinical radiographs.     

Changes in the pituitary-testicular system with age

In order to provide a comprehensive account of pituitary-testicular function in man, 466 subjects, ranging in age from 2 to 101 years, were studied to examine blood levels of the pituitary gonadotrophins (LH and FSH), the sex steroids testosterone and oestradiol, the binding capacity of the sex hormone binding globulin (SHBG), the free testosterone and oestradiol fractions, and the transfer constant for the peripheral conversion of testosterone to oestradiol. The results were compared with clinical indices of testicular size, sexual function and secondary sex hair distribution. Serum LH and FSH were low before puberty, increased in pubertal adolescents to levels somewhat above those of adults and subsequently increased progressively over the age of 40 years. Testosterone levels fell slowly after the age of 40, while there was a slight rise in plasma oestradiol with increasing age. FSH and testosterone showed small seasonal variations in young adult men, the lowest values being seen in winter. SHBG binding capacity was high in two prepubertal boys, fell in adult men, but increased in old age. Free testosterone and oestradiol levels fell in old age. The metabolic clearance rates (MCR) of testosterone and oestradiol also fell in old age, while the conversion of testosterone to oestradiol was increased. Many correlations were observed between various hormonal and clincial measurements. The evidence is consistent with a primary decrease in testicular function over the age of 40 years.     

Pulmonary gas exchange in acute mountain sickness

The severity of acute mountain sickness (AMS) was investigated in healthy volunteers, airlifted to high altitude (5,360 m). Blood gases were measured at 2,990 m and 5,360 m. Symptoms of AMS were found in all subjects, but ranged from malaise to vomiting with intractable headache. The clinical severity of AMS was directly related to the arterial PCO2 and inversely to pH, but unrelated to the PO2 on arrival at high altitude. However, PO2 fell and was lowest 48 h after arrival at high altitude in those subjects with the most severe AMS. These were the only subjects to show an increase in the alveolar-arterial PO2 difference and in the venous admixture ratio during the first 48 h. These abnormalities in gas exchange, which developed in the subjects with the most marked cerebral symptoms, suggest that the manifestations of cerebral and pulmonary dysfunction at altitude develop simultaneously, a finding that suggests coexisting cerebral and pulmonary edema.     

A METHOD FOR CONTROLLED OXYGENATION OF WORTS*

An improved method of oxygenation is described. This permits the introduction of precise amounts of oxygen into worts, without the creation of foam.     

Anti-disassembly using Cryptographic Hash Functions

Computer viruses sometimes employ coding techniques intended to make analysis difficult for anti-virus researchers; techniques to obscure code to impair static code analysis are called anti-disassembly techniques. We present a new method of anti-disassembly based on cryptographic hash functions which is portable, hard to analyze, and can be used to target particular computers or users. Furthermore, the obscured code is not available in any analyzable form, even an encrypted form, until it successfully runs. The method’s viability has been empirically confirmed. We look at possible countermeasures for the basic anti-disassembly scheme, as well as variants scaled to use massive computational power.     

Effects of filial therapy on parent and child behaviors.

Notes that filial therapy is a unique form of parent training that incorporates training in play therapy skills, parent-child play sessions, and supervision experiences. The objective is to help parents become therapeutic agents in their children's lives. This article explores the extent to which experimental studies have verified the accomplishment of this objective, identifies specific research instruments that have been used in filial therapy research, and summarizes findings. Additional areas for research are suggested. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evaluation of ADCP Apparent Bed Load Velocity in a Large Sand-Bed River: Moving versus Stationary Boat Conditions

Detailed mapping of bathymetry and apparent bed load velocity using a boat-mounted acoustic Doppler current profiler (ADCP) was carried out along a 388-m section of the lower Missouri River near Columbia, Missouri. Sampling transects (moving boat) were completed at 5- and 20-m spacing along the study section. Stationary (fixed-boat) measurements were made by maintaining constant boat position over a target point where the position of the boat did not deviate more than 3?m in any direction. For each transect and stationary measurement, apparent bed load velocity (vb) was estimated using ADCP bottom tracking data and high precision real-time kinematic (RTK) global positioning system (GPS). The principal objectives of this research are to (1)?determine whether boat motion introduces a bias in apparent bed load velocity measurements; and (2)?evaluate the reliability of ADCP bed velocity measurements for a range of sediment transport environments. Results indicate that both high transport (b>0.6??m/s) and moving-boat conditions (for both high and low transport environments) increase the relative variability in estimates of mean bed velocity. Despite this, the spatially dense single-transect measurements were capable of producing detailed bed velocity maps that correspond closely with the expected pattern of sediment transport over large dunes.