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91.
Aldo Todaro Rosa Palmeri Riccardo N. Barbagallo Pier Giorgio Pifferi Giovanni Spagna 《Food chemistry》2008
β-Glucosidase (EC 3.2.1.21) (β-G) from different sources were tested to increase the trans-resveratrol in some Sicilian wines by hydrolysing resveratrol glucoside. β-G from Aspergillus niger mould was tested as a crude and purified enzyme, and compared with the same enzyme from Saccharomyces cerevisiae yeast. Specific purification served to eliminate collateral enzyme activities so that β-G could be used simply and economically. Aspergillus niger β-G produced trans-resveratrol increases of up to 75%, with no change in physico-chemical properties and bouquet, and an increase in health and nutritional properties. S. cerevisiae β-G raised free-terpenol levels, but impaired wine colour due to anthocyanase activity. 相似文献
92.
Mamo Di Lella Riccardo Ramin 《变频器世界》2008,(11):106-107
当我们谈论效率时,我们主要指的是电力效率。然而,这种用法并不是效率一次本身的完整含义。在电力电子应用巾,工程师在开发新产品过程中的追求的主要目标是以最大限度地发挥不同类型的效率,如电效率和热效率,以及优化谐波失真和产品整体的尺寸。 相似文献
93.
This study aims to numerically and experimentally investigate the response of a medium strength rock material under unconfined compression loading up to failure. The unconfined compressive strength (UCS) is one of the most important parameters in characterising rock material behaviour. Hence the UCS is crucial in understanding the failure mechanism of fractured rocks. An effective approach to determine the UCS and to investigate the behaviours of rock materials under unconfined compression is essential in the majority of research fields of rock mechanics. The experimental configuration for the unconfined compression test, suggested by the protocols of the ASTM standard, has some limitations which affect the accuracy in determination of the real UCS. Among several alternative configurations proposed, the Mogi's configuration seems to be the most appropriate one. Therefore, the ASTM and Mogi's configurations were used to perform the tests on a medium strength rock material, i.e. Pietra Serena sandstone. The results using two configurations were discussed in terms of the differences. The tests were also replicated in LS-DYNA using a finite element method (FEM) coupled smooth particle hydrodynamics (SPH) technique. This technique is employed in this study due to its capabilities to cope with large deformation issues related to the rocks. An advanced material model, called the Karagozian and Case Concrete (KCC) model, is implemented in the numerical simulations. The KCC model consists of three independent fixed failure surfaces and it can consider the damage accumulation based on the current state of stress among these failure surfaces. An equation-of-state (EOS) is used in conjunction with KCC material model for decoupling the volumetric and deviatoric responses. The numerical and experimental results were finally compared with the focus on the stress–strain diagram and the failure patterns. The comparison shows that the numerical results are in good agreement with the experimental results. 相似文献
94.
Martino Di Serio Riccardo Tesser Vincenzo Russo Rosa Turco Rosa Vitiello Yongqiang Sun Wiesław Hreczuch 《Journal of surfactants and detergents》2015,18(5):913-918
The intermediates for the production of nonionic surfactants can be derived from petrochemicals and/or from renewable raw materials. In both, the role of catalysis is fundamental. In this paper the main results reported in the literature related with the catalysis for ethoxylation of fatty esters will be reviewed. The main open challenges for these technologies will be outlined. 相似文献
95.
Dr. Riccardo De Ricco Dr. Daniela Valensin Dr. Simone Dell'Acqua Prof. Dr. Luigi Casella Dr. Christelle Hureau Prof. Dr. Peter Faller 《Chembiochem : a European journal of chemical biology》2015,16(16):2319-2328
Copper binding to α‐synuclein (aS) and to amyloid‐β (Ab) has been connected to Parkinson's and Alzheimer's disease (AD), respectively, because Cu ions can modulate the peptide aggregation, and these Cu ? peptide complexes can catalyse the production of reactive oxygen species (ROS). In a significant proportion of AD brains, aggregation of aS and Ab has been detected, and it was proposed that Ab and aS interact with each other. Thus, we investigated the potential interactions of Ab and aS through their binding of copper(I) and copper(II). Additionally, β‐synuclein (bS) was investigated, due to its additional methionine residue, a potential CuI ligand. We found that: 1) the peptides containing the Cu‐binding domains Ab1–16, aS1–15 and bS1–15 have similar affinities towards CuII and towards CuI, with Ab1–16 being slightly stronger, 2) in the case of CuI, the additional Met residue in bS1–15 increased the affinity slightly, 3) the exchange of CuI/II between the two peptides is rapid (≤ms), 4) a/bS1–15 and Ab1–16 form a heterodimeric complex with CuII, 5) CuI probably promotes a transient ternary complex, 6) the different CuI/II coordination of Ab1–16, aS1–15 and bS1–15 impacts the capacity to produce ROS and to oxidise catechol, and 7) when Ab1–16, aS1–15 and Cu are present, the ROS production more closely resembles that by Ab1–16. The work gives insights into the coordination chemistry of these related peptides, and the relevance of coordination differences, the ternary complex and ROS production are discussed. 相似文献
96.
Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation
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Dr. Francesca Esposito Dr. Cristina Tintori Dr. Riccardo Martini Dr. Frauke Christ Prof. Zeger Debyser Roberto Ferrarese Dr. Gianluigi Cabiddu Dr. Angela Corona Dr. Elisa Rita Ceresola Dr. Andrea Calcaterra Dr. Valentina Iovine Prof. Bruno Botta Dr. Massimo Clementi Dr. Filippo Canducci Prof. Maurizio Botta Prof. Enzo Tramontano 《Chembiochem : a European journal of chemical biology》2015,16(17):2507-2512
HIV‐1 integrase (IN) active site inhibitors are the latest class of drugs approved for HIV treatment. The selection of IN strand‐transfer drug‐resistant HIV strains in patients supports the development of new agents that are active as allosteric IN inhibitors. Here, a docking‐based virtual screening has been applied to a small library of natural ligands to identify new allosteric IN inhibitors that target the sucrose binding pocket. From theoretical studies, kuwanon‐L emerged as the most promising binder and was thus selected for biological studies. Biochemical studies showed that kuwanon‐L is able to inhibit the HIV‐1 IN catalytic activity in the absence and in the presence of LEDGF/p75 protein, the IN dimerization, and the IN/LEDGF binding. Kuwanon‐L also inhibited HIV‐1 replication in cell cultures. Overall, docking and biochemical results suggest that kuwanon‐L binds to an allosteric binding pocket and can be considered an attractive lead for the development of new allosteric IN antiviral agents. 相似文献
97.
Ionic Polymer–Metal Composites (IPMCs) are electro-active polymers transforming mechanical forces into electric signals and vice versa. This paper proposes an improved electro-mechanical grey-box model for IPMC membrane working as actuator. In particular the IPMC nonlinearity has been characterized through experimentation and included within the electric model. Moreover identification of the model parameters has been performed via optimization algorithms using both single- and multi-objective formulation. Minimization was attained via the Nelder–Mead simplex and the Genetic Algorithms considering as cost functions the error between the experimental and modeled absorbed current and the error between experimental and modeled displacement. The obtained results for the different formulations have been then compared. 相似文献
98.
Changes in olive oil volatile organic compounds induced by water status and light environment in canopies of Olea europaea L. trees
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99.
Riccardo Matera Simone Gabbanini Gina Rosalinda De Nicola Renato Iori Gianna Petrillo Luca Valgimigli 《Food chemistry》2012
The freeze-dried sprouts’ juice of Raphanus sativus (L.) cv. Sango was prepared and analysed for the first time. HPLC analysis of total isothiocyanates, after protein displacement, resulted in 77.8 ± 3.0 μmol/g of dry juice while GC–MS analysis of hexane and acetone extracts showed E- and Z-raphasatin (8.9 and 0.11 μmol/g, respectively) and sulforaphene (11.7 μmol/g), summing up to 20.7 ± 1.7 μmol/g of free isothiocyanates. Sprouts’ juice contained an unprecedented wealth of anthocyanins and a new fractionation methodology allowed us to isolate 34 mg/g of acylated anthocyanins (28.3 ± 1.9 μmol/g), belonging selectively to the cyanidin family. Analysis was performed by HPLC–PDA–ESI–MSn and extended to deacylated anthocyanins and aglycones, obtained, respectively, by alkaline and acid hydrolysis. This study identified 70 anthocyanins, 19 of which have never been described before and 32 of which are reported here in R. sativus for the first time. Sango radish sprouts are exceptional dietary sources of heath-promoting micronutrients. 相似文献
100.
Riccardo Taormina Kwok-wing Chau Rajandrea Sethi 《Engineering Applications of Artificial Intelligence》2012,25(8):1670-1676
Artificial Neural Networks (ANNs) have been successfully employed for predicting and forecasting groundwater levels up to some time steps ahead. In this paper, we present an application of feed forward neural networks (FFNs) for long period simulations of hourly groundwater levels in a coastal unconfined aquifer sited in the Lagoon of Venice, Italy. After initialising the model with groundwater elevations observed at a given time, the developed FNN should able to reproduce water level variations using only the external input variables, which have been identified as rainfall and evapotranspiration. To achieve this purpose, the models are first calibrated on a training dataset to perform 1-h ahead predictions of future groundwater levels using past observed groundwater levels and external inputs. Simulations are then produced on another data set by iteratively feeding back the predicted groundwater levels, along with real external data. The results show that the developed FNN can accurately reproduce groundwater depths of the shallow aquifer for several months. The study suggests that such network can be used as a viable alternative to physical-based models to simulate the responses of the aquifer under plausible future scenarios or to reconstruct long periods of missing observations provided past data for the influencing variables is available. 相似文献