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991.
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DA Fein WR Lee AL Hanlon JA Ridge CJ Langer WJ Curran LR Coia 《Canadian Metallurgical Quarterly》1995,13(8):2077-2083
PURPOSE: A number of reports have documented the relationship between pretreatment hemoglobin level and local control and/or survival in the treatment of cervix, bladder, and advanced head and neck tumors. Consideration of correcting anemia before initiation of radiation therapy may prove increasingly important as clinical trials use intensive induction chemotherapy in the treatment of head and neck carcinomas. Neoadjuvant chemotherapy may produce anemia, which in turn may reduce the effectiveness of subsequent irradiation. MATERIALS AND METHODS: One hundred nine patients with T1-2N0 squamous cell carcinoma of the glottic larynx were treated with definitive radiotherapy at the Fox Chase Cancer Center between June 1980 and November 1990. Follow-up times ranged from 26 to 165 months (median, 82). RESULTS: The 2-year local control rate for patients who presented with a hemoglobin level < or = 13 g/dL was 66%, compared with 95% for patients with a hemoglobin level more than 13 g/dL (P = .0018). The 2-year survival rate for patients with a hemoglobin level < or = 13 g/dL was 46%, compared with 88% for patients with a hemoglobin level more than 13 g/dL (P < .001). Cox proportional hazards regression analysis showed that hemoglobin level (P = .0016) was the only variable that significantly influenced local control (P = .0016) and survival (P < .0001). CONCLUSION: Patients who presented with hemoglobin levels more than 13 g/dL had significantly higher local control and survival rates. The strong apparent correlation between hemoglobin level, local control, and survival supports consideration of correcting anemia before initiation of radiation therapy. 相似文献
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Plasma ferritin (F) concentrations were measured (range 12-245 ng.ml-1) as an indicator of iron status in 24 male and 45 female healthy, nonanemic athletes. Usual food intake was assessed using a self-completed but supervised food frequency questionnaire. Linear regression was applied to determine the relationship between log F (as data was skewed) and average daily intake of iron (Fe), meat (M), protein (Pr), carbohydrate (CHO), fat (Fa), fiber (Fi), and kilojoules (Kj). There were negative correlations between F and each of Kj (P < 0.01) and CHO (P < 0.001), and a positive correlation between F and Pr/Kj (P < 0.01). No significant relationship existed between F and any of Fe, M, Fa, or Fi. These data suggest that iron or meat intake may not be important determinants of iron status in these athletes. Instead, the percentage of protein in the diet may be more influential on F, as may the (negative) effect of Kj and CHO intake, or at least their reflection of energy expenditure. 相似文献
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DA Imoedemhe AB Sigue EL Pacpaco AB Olazo EC Luciano 《Canadian Metallurgical Quarterly》1995,10(11):2970-2975
Embryos obtained from patients undergoing routine in-vitro fertilization (IVF) and embryo transfer were compared with those undergoing subzonal microinsemination (SUZI) for male factor infertility. Overall, the proportion of cleaved embryos was significantly higher in the IVF group in comparison with the SUZI group at 48 h post-insemination [1533 out of 1609 (95.3%) versus 776 out of 952 (81.5%)]. The mean +/- SD grading score of the IVF-derived embryos of 3.61 +/- 0.50 was significantly better than that for SUZI of 2.97 +/- 0.86 (P < 0.0005) at the same time. The implantation rates following the replacement of IVF or SUZI embryos at 48 h were comparable: 14.3 and 10.0% respectively. However, the IVF embryo implantation rate of 15.1% at 72 h was significantly better than that following the replacement of SUZI embryos at either 48 (10.0%) or 72 h (8.0%). The replacement of SUZI-derived embryos at 48 h resulted in significantly higher pregnancy (25.0%) and implantation rates (10.0%) than at 72 h, with rates of 10.8 and 8.0% respectively. Similarly, the overall embryo quality deteriorated following in-vitro culture for up to 72 h. The clinical pregnancy loss rate (33.0%) was highest following the replacement of SUZI embryos at 72 h, although the data were limited. It is suggested that these data indicate that a combination of in-vitro manipulation, the injection of multiple spermatozoa into the subzonal space and probably the genomic capacity of spermatozoa derived from poor-quality semen may contribute to the poorer outcome of embryo development following SUZI. Prolonged in-vitro culture beyond 48 h appears to be deleterious to the development of SUZI cleaved embryos and the subsequent outcome of treatment, and hence should be avoided. 相似文献
999.
BACKGROUND: Previous studies suggest differences in the fixation disparity curves obtained with the Sheedy Disparometer and the Wesson Fixation Disparity Card, the two most commonly used methods for measuring fixation disparity. In one study the investigators proposed that the differences do not exist for subgroups divided by phoria. The purpose of this paper is to try to clarify this issue by use of two large sets of data. METHODS: Dissociated phorias were measured by the von Graefe method. Fixation disparity curves were plotted using the Disparometer and the Wesson card. RESULTS: Type I fixation disparity curves were most common with the Wesson card. Type II curves were found more often with the Disparometer than with the Wesson card. The x-intercepts were shifted in the base-in (BI) direction with the Wesson card compared to the Disparometer. The y-intercepts were shifted in the exo direction with the Wesson card compared to the Disparometer. The differences were statistically significant regardless of whether the dissociated phoria was exo or eso. The slope of the fixation disparity curve was steeper with the Wesson card than with the Disparometer. The difference was statistically significant for exophores but not for esophores. The differences between results obtained with the two instruments are not consistent from one subject to another as shown by high standard deviations of the differences. CONCLUSIONS: The fixation disparity curves measured with these two instruments are different. Fixation disparity parameters obtained from one of these instruments cannot be used with normative findings from the other. 相似文献
1000.