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Eliaz N Ritman-Hertz O Aronov D Weinberg E Shenhar Y Rosenman G Weinreb M Ron E 《Journal of materials science. Materials in medicine》2011,22(7):1741-1752
The effect of different mechanical and chemical pre-treatments on the adhesion strength of hydroxyapatite (HAp) coating on
a commercially pure titanium (CP-Ti) substrate was studied by means of a standard tensile test followed by microscopic and
chemical analysis to determine the locus of fracture. In addition, the effects of either these pre-treatments or post-treatment
by low-energy electron irradiation, which allowed tuning the wettability of the surface, on both osteoblast progenitor attachment
and S. aureus bacteria attachment were investigated. A dedicated program was developed for unambiguous identification and count of stained
cells. A single-phase HAp coating was formed by electrodeposition. A series of surface pre-treatments consisted of grinding
down to P1000, etching in HNO3/HF solution, grit blast, soaking in NaOH and subsequent heat treatment provided the highest adhesion strength to the HAp
coating. Osteoblast progenitors derived from rats may be attached preferentially to a hydrophilic surface (post-treatment
to θ = 30°), while the bacteria seemed to be less attached to hydrophobic surfaces (post-treatment to θ = 105°). However, the results were not statistically different. The bacteria seemed to be less attached to the smoother,
uncoated surfaces. 相似文献
154.
Bloemberg TG Wessels HJ van Dael M Gloerich J van den Heuvel LP Buydens LM Wehrens R 《Analytical chemistry》2011,83(13):5197-5206
The identification of differential patterns in data originating from combined measurement techniques such as LC/MS is pivotal to proteomics. Although "shotgun proteomics" has been employed successfully to this end, this method also has severe drawbacks, because of its dependence on largely untargeted MS/MS sequencing and databases for statistical analyses. Alternatively, several MS-signal-based (MS/MS-independent) methods have been published that are mainly based on (univariate) Student's t-tests. Here, we present a more robust multivariate alternative employing linear discriminant analysis. Like the t-test-based methods, it is applied directly to LC/MS data, instead of using MS/MS measurements. We demonstrate the method on a number of simulated data sets, as well as on a spike-in LC/MS data set, and show its superior performance over t-tests. 相似文献
155.
Organic Electronics: Spatial Mapping of Morphology and Electronic Properties of Air‐Printed Pentacene Thin Films (Adv. Funct. Mater. 25/2014) 下载免费PDF全文
156.
Cleo C. L. van Aanhold Angela Koudijs Kyra L. Dijkstra Ron Wolterbeek Jan A. Bruijn Cees van Kooten Hans J. Baelde 《International journal of molecular sciences》2022,23(17)
(1) Background: Soluble Fms-like tyrosine kinase 1 (sFLT1) is an endogenous VEGF inhibitor. sFLT1 has been described as an anti-inflammatory treatment for diabetic nephropathy and heart fibrosis. However, sFLT1 has also been related to peritubular capillary (PTC) loss, which promotes fibrogenesis. Here, we studied whether transfection with sFlt1 aggravates experimental AKI-to-CKD transition and whether sFLT1 is increased in human kidney fibrosis. (2) Methods: Mice were transfected via electroporation with sFlt1. After confirming transfection efficacy, mice underwent unilateral ischemia/reperfusion injury (IRI) and were sacrificed 28 days later. Kidney histology and RNA were analyzed to study renal fibrosis, PTC damage and inflammation. Renal sFLT1 mRNA expression was measured in CKD biopsies and control kidney tissue. (3) Results: sFlt1 transfection did not aggravate renal fibrosis, PTC loss or macrophage recruitment in IRI mice. In contrast, higher transfection efficiency was correlated with reduced expression of pro-fibrotic and pro-inflammatory markers. In the human samples, sFLT1 mRNA levels were similar in CKD and control kidneys and were not correlated with interstitial fibrosis or PTC loss. (4) Conclusion: As we previously found that sFLT1 has therapeutic potential in diabetic nephropathy, our findings indicate that sFLT1 can be administered at a dose that is therapeutically effective in reducing inflammation, without promoting maladaptive kidney damage. 相似文献
157.
RonDeLong BrianThorsen GrekRichmond 《今日电子》2004,(3):16-17,15
电场成像器件IC(MC33794):Motorola公司提供行业内惟一可产生及检测低水平电场和功率并支持微控制器(MCU)的集成电路(IC),所有这些功能均集成在单个芯片中。 相似文献
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Michael Burke Ron Cytron Jeanne Ferrante Wilson Hsieh 《The Journal of supercomputing》1989,3(2):71-88
This paper presents an efficient algorithm that automatically generates a parallel program from a dependence-based representation of a sequential program. The resulting parallel program consists of nested fork-join constructs, composed from the loops and statements of the sequential program. Data dependences are handled by two techniques. One technique implicitly satisfies them by sequencing, thereby reducing parallelism. Where increased parallelism results, the other technique eliminates them by privatization: the introduction of process-specific private instances of variables. Additionally, the algorithm determines when copying values of such instances in and out of nested parallel constructs results in greater parallelism. This is the first algorithm for automatically generating parallelism for such a general model. The algorithm generates as much parallelism as is possible in our model while minimizing privatization.An earlier version of this paper was presented at the First Workshop on Languages and Compilers for Vector and Parallel Machines, which was held at Cornell University in August 1988. That same year a select group of these workshop papers were published in two special issues of the journal: volume 2, numbers 2 and 3. 相似文献
160.