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51.
CG Persson JS Erjef?lt L Greiff M Andersson I Erjef?lt RW Godfrey M Korsgren M Linden F Sundler C Svensson 《Canadian Metallurgical Quarterly》1998,11(4):958-970
One significant characteristic of the airway mucosa in vivo, that cannot easily be mimicked in vitro, is its microcirculation, which generates a highly dynamic, biologically active milieu of plasma-derived molecules that may pass to the airway lumen in vivo. New data on the mechanisms of airway mucosal exudation indicate that the protein systems of circulating plasma may contribute significantly to the biology and immunology of the lamina propria, its surface epithelium and the luminal surface, not only in injured airways, but also in airways that are activated but display no sign of oedema, epithelial disruption, or increased absorption capacity. We suggest that present knowledge of the mechanisms of plasma exudation, together with rapidly emerging information (not detailed herein) on receptors, target cells and cellular responses to the plasma-derived molecules, must be considered in any realistic model that investigates "immuno-inflammatory" mechanisms of the airway mucosa. 相似文献
52.
PAN Bin ZHONG Fan WANG Shuai CHEN Wei & PENG QunSheng The State Key Lab of CAD & CG Hangzhou China 《中国科学:信息科学(英文版)》2011,(6):1199-1206
Salient structural elements are ubiquitous in natural textures, and their distribution exhibits some stochastic distribution features. Current texture synthesis algorithms can neither preserve the integrity of the elements nor capture this distributive information. We present an algorithm to treat this high-level visual information. Here, we address the issue by taking specific care of the structural elements. Our texture synthesis process grows the target texture one structural element at a time. A Markov ... 相似文献
53.
Rubén Fuentes-Fernández Iván García-Magariño Alma María Gómez-Rodríguez Juan Carlos González-Moreno 《Engineering Applications of Artificial Intelligence》2010,23(3):432-444
The formalization of engineering processes is necessary for guaranteeing the quality and cost of the products involved. Agent-oriented engineering has already proposed development processes that still need to be further formalized to be applicable by non-researchers. This paper proposes a technique to instantiate processes for specific agent-oriented methodologies. This technique is based on three orthogonal views that are respectively related with lifecycles, disciplines and guidances. In addition, processes are modeled with a tool, which is automatically generated from a process metamodel inspired by the software & systems process engineering metamodel. Accordingly, engineers can choose the methodology–process pair best-suited for the characteristics of their project. The paper illustrates the approach based on the unified development process and the scrum process for the INGENIAS methodology and compares the results with other existing alternatives. 相似文献
54.
Iván García-Magariño Rubén Fuentes-Fernández Jorge J. Gómez-Sanz 《Information and Software Technology》2010,52(4):422-435
Computer-Aided Software Engineering (CASE) tools support modeling-related activities in development projects. Given the variety of tools and functionalities, it is quite common to work with several tools in the same project. However, data cannot usually be exchanged between these tools without loss of information. Recent approaches address this model interchange problem using metamodels to characterize the involved information and transformations to export/import it. Nevertheless, most of these solutions focus on the abstract syntax of models. They fail to consider aspects such as the presentation of models or tool-specific information, which are either disregarded or represented in ad-hoc ways that make difficult their processing. In order to overcome these limitations, this paper introduces a framework to define metamodels of CASE tools and a process to carry out the model interchange using them. The proposed metamodels have a modular organization with several internal metamodels. Each of them is aimed at describing some specific information about content, structure and presentation for both models and tools. The paper illustrates this approach with a case study used for comparison with existing works for this problem. 相似文献
55.
The universal cover T
G
of a connected graph G is the unique (possibly infinite) tree covering G, i.e., that allows a locally bijective homomorphism from T
G
to G. It is well-known that if a graph G covers a graph H, then their universal covers are isomorphic, and that the latter can be tested in polynomial time by checking if G and H share the same degree refinement matrix. We extend this result to locally injective and locally surjective homomorphisms
by following a very different approach. Using linear programming techniques we design two polynomial time algorithms that
check if there exists a locally injective or a locally surjective homomorphism, respectively, from a universal cover T
G
to a universal cover T
H
(both given by their degree matrices). This way we obtain two heuristics for testing the corresponding locally constrained
graph homomorphisms. Our algorithm can also be used for testing (subgraph) isomorphism between universal covers, and for checking
if there exists a locally injective or locally surjective homomorphism (role assignment) from a given tree to an arbitrary
graph H. 相似文献
56.
57.
Juan C. Granda Pelayo Nuño Julio Molleda Rubén Usamentiaga Daniel F. García 《Multimedia Systems》2016,22(5):543-557
Real-time interactive multimedia communications are becoming increasingly useful for education, business, e-commerce and e-government, providing an enriched user experience in teleconferencing, e-meetings, distance training and product demonstrations. Large corporations are usually located at several sites, so real-time multipoint sessions within corporations are especially difficult. IP multicast is available or feasible within each site of an organization. Thus, corporate networks can be considered as various multicast-capable networks interconnected through a wide area network without multicast connectivity. This paper proposes a resilient self-managed overlay network to support real-time multipoint interactive sessions within corporate networks. The proposed overlay takes advantage of the configuration of corporate networks to self-organize and provide an efficient media delivery service, making use of multicast communications wherever available. Various self-healing techniques are implemented allowing for the continuity of ongoing sessions in spite of network disruptions and entity failures. Extensive simulations and tests have been carried out to assess the performance and resilience of the overlay facing several types of disruptions. 相似文献
58.
Alvarez I Carrascal M Canals F Muixí L Abián J Jaraquemada D 《Proteomics. Clinical applications》2007,1(3):286-298
HLA class I molecules present peptides on the cell surface to CD8(+) T cells. The repertoire of peptides that associate to class I molecules represents the cellular proteome. Therefore, cells expressing different proteomes could generate different class I-associated peptide repertoires. A large number of peptides have been sequenced from HLA class I alleles, mostly from lymphoid cells. On the other hand, T cell immunotherapy is a goal in the fight against cancer, but the identification of T cell epitopes is a laborious task. Proteomic techniques allow the definition of putative T cell epitopes by the identification of HLA natural ligands in tumor cells. In this study, we have compared the HLA class I-associated peptide repertoire from the hepatocellular carcinoma (HCC) cell line SK-Hep-1 with that previously described from lymphoid cells. The analysis of the peptide pool confirmed that, as expected, the peptides from SK-Hep-1 derive from proteins localized in the same compartments as in lymphoid cells. Within this pool, we have identified 12 HLA class I peptides derived from HCC-related proteins. This confirms that tumor cell lines could be a good source of tumor associated antigens to be used, together with MS, to define putative epitopes for cytotoxic T cells from cancer patients. 相似文献
59.
AD Gouliamos DS Kontogiannis J Androulidakis AE Kalovidouris LJ Vlahos CG Papavasiliou 《Canadian Metallurgical Quarterly》1993,17(3):446-448
The MR studies of three histologically proven spinal neurilemmomas and neurofibromas were reviewed retrospectively. There were two benign neurilemmomas (schwannomas) and one neurofibroma. The common characteristic of these cases was a central low intensity focus ("dot") seen on postcontrast T1-weighted imaging. The low intensity foci corresponded histologically to a congeries of changes including edema, microcysts, foam cells, hyalinization of blood vessels, old hemorrhage, and dystrophic calcification. 相似文献
60.
RE Falcone SR Wanamaker F Barnes CG Baxter SA Santanello 《Canadian Metallurgical Quarterly》1993,3(4):325-329
The number of people smoking free-base cocaine, or "crack," has increased dramatically in recent years. Concomitantly, the literature describing complications of such use has grown as well. Adverse pulmonary effects are being increasingly noted, such as respiratory symptoms, pulmonary hemorrhage, pulmonary edema, asthma, and pulmonary barotrauma. These and other pulmonary effects are reviewed. 相似文献