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91.
I Kohno H Iwasaki M Okutani Y Mochizuki S Sano Y Satoh T Ishihara H Ishii S Mukaiyama H Ijiri S Komori K Tamura 《Canadian Metallurgical Quarterly》1997,14(1):71-84
Cells of the central nervous system (CNS) normally do not express detectable levels of major histocompatibility complex (MHC) Class I antigens. However, MHC Class I expression can be induced after virus infection. We tested the hypothesis that virus-induced Class I expression is mediated by lymphocytes or cytokines using lymphocyte- and cytokine-deficient mice. We used Theiler's murine encephalomyelitis virus (TMEV), which induces CNS demyelination that maps genetically to the D region of MHC Class I and is associated with high levels of Class I products. TMEV infection of severe combined immunodeficiency (SCID) and recombination activation gene-1-deficient mice, which lack B and T lymphocytes, resulted in equivalent H-2D and H-2K expression in brain and spinal cord, according to analysis of the area and intensity of immunoperoxidase staining. Class I antigens were demonstrated as early as 6 hours after infection, and they were more widely distributed than viral RNA, indicating that expression was induced indirectly via a soluble factor. To determine whether cytokines induced the expression, we infected mice lacking receptors for interferon-alpha/beta (IFN-alpha/beta R (-/-)), interferon-gamma (IFN-gamma R(-/-)), and tumor necrosis factor-alpha (TNFRp55(-/-)). TMEV-infected IFN-gamma R(-/-) and TN-FRp55(-/-) mice expressed Class I antigens in the CNS, whereas IFN-alpha/beta R(-/-) mice did not, establishing that IFN-alpha/beta mediated the expression. In contrast to the equivalent expression in SCID mice, we observed greater area and higher intensity of H-2D versus H-2K antigens in infected SCID mice reconstituted with normal spleen cells. Collectively, the data indicate that after TMEV infection, early generalized MHC Class I expression is mediated by IFN-alpha/beta independently of lymphocytes, but the differential regulation of H-2D over H-2K may be controlled by B and/or T lymphocytes. 相似文献
92.
J. Enrique Juli Yang Liu Sidharth Paranjape Mamoru Ishii 《Nuclear Engineering and Design》2008,238(1):156-169
Traditionally, the flow regimes in two-phase flow are considered in a global sense. However, a local flow regime is required to understand and model the interfacial structures present in the flow. In this work, a new approach has been used to identify both global and local flow regimes in a two-phase upward flow in a 50.8 mm internal diameter pipe under adiabatic conditions. In the present method, the bubble chord length distributions, which are measured simultaneously with three double-sensor conductivity probes, have been used to feed a self-organized neural network. The global flow regime identification results show a reasonable agreement with the visual observation for all the flow conditions. Nonetheless, only the local flow regimes measured at the center of the pipe agree with the global ones. The local flow regime combinations found are analyzed using the flow map information, cross-correlations between the probe signals, and previous correlations. In this way, it is possible to identify eight different global flow regime configurations. 相似文献
93.
We have evaluated the optical properties of close‐packed and non close‐packed colloidal crystalline arrays made of hollow polystyrene spheres. Close‐packed colloidal crystalline arrays were fabricated by simple evaporation of dispersions, whereas nonclose‐packed colloidal crystalline arrays were fabricated by exploiting electrostatic interactions between the spheres in aqueous dispersion. Optical properties of the arrays were estimated from angle‐resolved reflection spectra. The Bragg diffraction peak of the colloidal crystalline array made of hollow spheres was of shorter wavelength than in the case of solid spheres, not only for the close‐packed array but also for the nonclose‐packed array. These shifts were caused by a decrease in the effective refractive index neff with decreasing particle refractive index. We have found that this relationship could be explained by the simple equation neff = nparticle?+ nsolvent (1 ? ?), where ? is the volume fraction of the particles, for both close‐packed and non close‐packed arrays. The current work suggests new possibilities for the creation of advanced colloidal crystals. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2364–2368, 2007 相似文献
94.
Ishii T. Osabe T. Mine T. Sano T. Atwood B. Yano K. 《Electron Devices, IEEE Transactions on》2004,51(11):1805-1810
This work presents a gain-cell solution in which a novel ultrathin polysilicon film transistor provides the basis for dense and low-power embedded random-access memory (RAM). This is made possible by the new transistor's 2-nm-thick channel, which realizes a quantum-confinement effect that produces a low leakage current value of only 10/sup -19/ A at room temperature. The memory has the potential to solve the power and stability problems that static RAM (SRAM) is going to face in the very near future. 相似文献
95.
Byappanahalli MN Whitman RL Shively DA Ferguson J Ishii S Sadowsky MJ 《Water research》2007,41(16):3649-3654
We previously reported that the macrophytic green alga Cladophora harbors high densities (up to 10(6) colony-forming units/g dry weight) of the fecal indicator bacteria, Escherichia coli and enterococci, in shoreline waters of Lake Michigan. However, the population structure and genetic relatedness of Cladophora-borne indicator bacteria remain poorly understood. In this study, 835 E. coli isolates were collected from Cladophora tufts (mats) growing on rocks from a breakwater located within the Indiana Dunes National Lakeshore in northwest Indiana. The horizontal fluorophore enhanced rep-PCR (HFERP) DNA fingerprinting technique was used to determine the genetic relatedness of the isolates to each other and to those in a library of E. coli DNA fingerprints. While the E. coli isolates from Cladophora showed a high degree of genetic relatedness (92% similarity), in most cases, however, the isolates were genetically distinct. The Shannon diversity index for the population was very high (5.39). Both spatial and temporal influences contributed to the genetic diversity. There was a strong association of isolate genotypes by location (79% and 80% for lake- and ditch-side samplings, respectively), and isolates collected from 2002 were distinctly different from those obtained in 2003. Cladophora-borne E. coli isolates represented a unique group, which was distinct from other E. coli isolates in the DNA fingerprint library tested. Taken together, these results indicate that E. coli strains associated with Cladophora may be a recurring source of indicator bacteria to the nearshore beach. 相似文献
96.
Xu D. Suemitsu T. Osaka J. Umeda Y. Yamane Y. Ishii Y. Ishii T. Tamamura T. 《Electron Device Letters, IEEE》1999,20(5):206-208
We have developed high-performance enhancement-mode InP-based modulation-doped field-effect transistors with 0.03 μm gate-length. A record high current gain cutoff frequency exceeding 300 GHz has been achieved, and the maximum extrinsic transconductance is as high as 2 S/mm with an associated drain current of 0.5 A/mm at a drain bias of 1 V. This high performance is a result of the reduction or gate length, the use of the high barrier metal Pt as gate electrodes, and most importantly the employment of the well-developed wet-etching technology that allows the formation of a very deep gate groove while retaining small side etching. The excellent E-MODFET performance opens up the possibility of implementing ever faster high-speed circuits based on direct-coupled FET logic 相似文献
97.
Kunikazu Ishii Natsuko FujitaHidemi Ogawa 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2011,269(9):1026-1028
We have developed a simple Rutherford backscattering spectroscopic (RBS) method to analyze sample depth profiles in air. To avoid excessive energy loss of projectile ions in air, we have used a 3 MeV proton beam extracted into air with a metal capillary. Using this capillary, we were able to extract a sufficiently large proton beam current to perform in-air RBS and in-air PIXE without requiring any window, such as a thin film, between a vacuum chamber and air. We have validated our technique by analyzing the depth profiles for Au foils of various thicknesses, 0.25, 0.75, and 2.5 μm. A comparison of the experimental results with a simple theoretical calculation indicates that this technique is useful for analyzing the depth profile of any specimen in air. 相似文献
98.
There are many cases when a neural-network-based system must memorize some new patterns incrementally. However, if the network learns the new patterns only by referring to them, it probably forgets old memorized patterns, since parameters in the network usually correlate not only to the old memories but also to the new patterns. A certain way to avoid the loss of memories is to learn the new patterns with all memorized patterns. It needs, however, a large computational power. To solve this problem, we propose incremental learning methods with retrieval of interfered patterns (ILRI). In these methods, the system employs a modified version of a resource allocating network (RAN) which is one variation of a generalized radial basis function (GRBF). In ILRI, the RAN learns new patterns with a relearning of a few number of retrieved past patterns that are interfered with the incremental learning. We construct ILRI in two steps. In the first step, we construct a system which searches the interfered patterns from past input patterns stored in a database. In the second step, we improve the first system in such a way that the system does not need the database. In this case, the system regenerates the input patterns approximately in a random manner. The simulation results show that these two systems have almost the same ability, and the generalization ability is higher than other similar systems using neural networks and k-nearest neighbors. 相似文献
99.
Sho Shirakata Katsuhiko Ohkubo Yasuyuki Ishii Tokio Nakada 《Solar Energy Materials & Solar Cells》2009,93(6-7):988-992
Photoluminescence (PL) have been studied on Cu(In,Ga)Se2 (CIGS) thin films, CdS/CIGS and CIGS solar cells, to clarify the carrier recombination process. The chemical-bath deposition (CBD) of the CdS buffer layer on the CIGS thin film leads to (i) the enhancement of near-band-edge PL intensity by a factor of 2–3, (ii) change in energy of the defect-related PL and (iii) the slight change in the decay time. They are related not only to the minimization of the surface recombination but also to the modification of native defects at the Cu-poor surface of CIGS by the occupation of Cd atom at the Cu site. A donor–acceptor pair PL at low-temperature and temperature-dependent PL have been studied. They are discussed in terms of the impurity and defect levels created in the CIGS film during the CBD-CdS process. 相似文献
100.
Ishii H. Sugiyama K. Yoshimura D. Ito E. Ouchi Y. Seki K. 《IEEE journal of selected topics in quantum electronics》1998,4(1):24-33
The electronic structures of model interfaces of organic electroluminescent (EL) devices were investigated with UV photoemission spectroscopy (UPS). Interfaces of TTN (tetrathianaphthacene) and TCNQ (tetracyanoquinodimethane) were also studied as extreme cases for hole transport and electron transport material, respectively. For all organic/metal interfaces studied, the work function of metal electrode was changed by deposition of organic layer, i.e., the vacuum level was shifted at the interface, indicating the invalidity of the traditional energy level alignment model where a common vacuum level was assumed at organic/metal interface. At TCNQ/Au, DP-NTCI/Al, which are acceptor/metal interfaces, upward shift of the vacuum level of organic layer relative to that of metal was observed, suggesting the formation of interfacial dipole due to electron-transfer from metal to acceptor. At other organic/metal interfaces, TPD(N, N'-diphenyl-N, N'-(3-methylphenyl)-1, 1'-biphenyl-4, 4'-diamine)/Au or ITO (indium tin oxide), ALq/sub 3/ (tris(8-hydroxyquinolino) aluminum)/Al, DP-NTCl(N, N'-diphenyl-1,4,5,8- naphthyltetracarboxylimide)/Al or Au, downward shift of the vacuum level was observed. Such downward shift has been also observed in our previous study for porphyrin/metal interfaces, and seems to be a trend for organic/metal interfaces at which no electron-transfer from metal to organic layer occurs. This trend suggests that the traditional model tends to underestimate (overestimate) the barrier height for hole (electron) injection. On the other hand, the vacuum level shift at ALq/sub 3//TPD interface was less than 0.1 eV, leading to an apparent applicability of the traditional model. However, it is not always the case for organic/organic interfaces: finite shift of 0.2 eV was observed at TTN/TCNQ interface due to electron-transfer from TTN to TCNQ. Possible origins of vacuum level shift at organic/metal interfaces were also discussed. 相似文献